The Scope

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[The Scope @MedicineScope]

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Why does every BMP report show a GFR - African American and GFR - non-African American for the same Cr value?

Let's focus on #racecorrection in the estimation of GFR as part of our ongoing series on racial bias in medicine.

[Adam Widman @adamjwidman]

So incredibly proud to introduce our new liquid biopsy platform MRD-EDGE on @biorxivpreprint! MRD-EDGE is a crucial next step in our lab’s effort to capitalize on the breadth of signal available from plasma whole genome sequencing (WGS). THREAD https://t.co/WX3TjWECHU

[The Scope @MedicineScope]

Thanks for reading, and check out our emails on Friday and following tweets about the issues!

#medtwitter #endotwitter #medtweetorials

[The Scope @MedicineScope]

Hello again #medtwitter!

We're starting a new effort to take a step back and dive a bit more into our "Say it On Rounds" summaries!

Today: from the 12/4 issue, "Once-Weekly Insulin for Type 2 Diabetes without Previous Insulin Treatment"
(10.1056/NEJMoa2022474)

[The Scope @MedicineScope]

Summary

🔘self-management of diabetes using daily injections can be cumbersome and a barrier to proper management

🔘Icodec is a promising solution here but does require more investigation!

[The Scope @MedicineScope]

➡️SOLIDARITY: negative findings with anti-retroviral data for patients with COVID-19, contrasting ACTT-1 results from earlier this year. https://t.co/89Gkyti5U3

[The Scope @MedicineScope]

Your Friday email is now out and ready for consumption!

➡️Vaccines💉: Summary of the Pfizer + Moderna, now granted EUA by the FDA. https://t.co/mUHrfES8T6

➡️IV iron Fe(ver)😏: an RCT of IV iron vs placebo for > 1,000 pts with HFrEF and 🔽Iron. https://t.co/yFL0bYplmF

[The Scope @MedicineScope]

@ImageAltText

[The Scope @MedicineScope]

Hey, #MedTwitter! We've been thinking a lot about SGLT2i (more coming up on your Friday email) in heart failure, and wanted to give space for overview of the evidence and potential mechanisms.

So without further ado, here's a #tweetorial on #SGLT2i and #HeartFailure!

[The Scope @MedicineScope]

2/ A Background:

SGLT1 and SGLT2 are co-transporters that move glucose and Na+ into the tubular lumen. SGLT2 is responsible for 90% of glucose reabsorption, while SGLT1 is responsible for 10%, and also found on intestinal epithelial cells.

[The Scope @MedicineScope]

If you have any more insights or clarifyications, let us know, #MedTwitter! We know this is an expansive and rapidly changing topic!

[The Scope @MedicineScope]

3/ The Beginning

Phlorizin, found in the root bark of an🍎, was first isolated in 1835. But we have to fast forward to 2013, when the FDA approved Canagliflozin in 2013 for DM2 treatment, followed by Dapagliflozin and Empagliflozin in 2014.

[The Scope @MedicineScope]

Image References:

https://t.co/nhg9YAefGd
https://t.co/ioYQWB6dBz
https://t.co/oabgLlgO4k
https://t.co/sMMiCt1E7B
https://t.co/Ti0E8oyV7X