Adam Widman

Physician-scientist @sloan_kettering. Liquid biopsy, AI and cancer genomics

[Adam Widman @adamjwidman]

MRD-EDGE is out today in @NatureMedicine! Thrilled to see this in print when the future for #ctdna in plasma whole genome sequencing is brighter than ever.

[Adam Widman @adamjwidman]

How do you scale up liquid biopsy for use in routine cancer monitoring? Combine plasma-only ultrasensitive detection with cheap sequencing and a simple lab workflow. A big thanks to @AlexandrePCheng for pushing this work over the finish line! Stay tuned and more to come

[Alexandre Pellan Cheng @AlexandrePCheng]

What happens when sequencing costs go ⏬ ?
Imagination and new opportunities go ⏫ @landau_lab

Let's look at what you can do when you perform deep WGS on cfDNA for cancer detection. Our recent work with the @UltimaGenomics platform 🧵👇
Lets goooo!!
https://t.co/ZMaJqUKNDK

[Nature Methods @naturemethods]

The integration of duplex sequencing with cost-effective Ultima sequencing enhances the accuracy of whole-genome circulating cell-free DNA profiling.
@landau_lab @AlexandrePCheng

https://t.co/irHXyJgO7X

[Adam Widman @adamjwidman]

Thanks @amanda_fbj and @ClausLindbjerg for leading here! Very excited to see this out in print

[Amanda Frydendahl Boll Johansen @amanda_fbj]

💡New paper out in @MolOncology demonstrating detection of #ctDNA in patients with #colorectal #adenomas by #WGS (MRD-EDGE)!

Thanks for great collab @landau_lab & @adamjwidman!

@ClausLindbjerg @JesperNors @GaardNadia @TennaVesterman @moma_dk @AUHdk

https://t.co/JdVboAUGIq

[Adam Widman @adamjwidman]

Congrats Nico and Will and Bishoy and team!

[Nicolas Robine @notSoJunkDNA]

Special nugget for my genomics friends in today's paper: Read everything but don't miss Extended Data Fig. 8, where @willbfx assembled a CCND1-ecDNA from @nanopore reads!

[Adam Widman @adamjwidman]

Congrats to Josh and team!

[Josh Schiffman @jsschiffman]

Excited to share "Defining heritability, plasticity, and transition dynamics of cellular phenotypes in somatic evolution", from an amazing collaboration with @landau_lab @ar_davino @TamaraPrietoF @hara_toshiro @MarioSuva!

A tweetorial, or Xplanation ...

https://t.co/i9aYCTIuO8

[Pashtoon Kasi MD, MS @pashtoonkasi]

#NESTTrial 🪺 responses to date.🙌🏾
What’s particularly of note is the deepening of the responses with longer time to brew 🫖. The pattern🌊 and lack of recurrence speaks to curative potential of immunotherapy for both MSS and MSI-High tumors. #CRCSM

@myESMO #ESMOGI24 @OncoAlert

[Marcin Imieliński @skimomiks]

parts per million -> parts per billion -> parts per trillion? how low can we go with ctDNA detection in the era of dirt cheap whole genomes ?? .. momentous milestone by @adamjwidman @landau_lab & team👇👇👇

[Eric Topol @EricTopol]

A major problem with cell-free tumor DNA to detect cancer (Liquid biopsy) is its very low quantity. Today @NatureMedicine use of #AI to overcome that issue with impressive results for radical signal-to-noise enrichment
https://t.co/zMWaq3F8jP
free access https://t.co/VPLpESbw3a

[Adam Widman @adamjwidman]

Open link- https://t.co/RU6PZafIug

[Adam Widman @adamjwidman]

MRD-EDGE is out today in @NatureMedicine! Thrilled to see this in print when the future for #ctdna in plasma whole genome sequencing is brighter than ever.

[Adam Widman @adamjwidman]

In the future the ability to monitor tumor burden after every intervention will completely transform cancer care. Let’s build the tools to get there!

[Weill Cornell Medicine @WeillCornell]

An artificial intelligence-powered method for detecting tumor DNA in blood has shown unprecedented sensitivity in predicting cancer recurrence, says a team led by Dr. Dan Landau (@landau_lab) and researchers at @nygenome and @MSKCancerCenter.

https://t.co/2ZCZMnsnBG