MRD-EDGE is out today in @NatureMedicine! Thrilled to see this in print when the future for #ctdna in plasma whole genome sequencing is brighter than ever.
How do you scale up liquid biopsy for use in routine cancer monitoring? Combine plasma-only ultrasensitive detection with cheap sequencing and a simple lab workflow. A big thanks to @AlexandrePCheng for pushing this work over the finish line! Stay tuned and more to come
What happens when sequencing costs go ⏬ ?
Imagination and new opportunities go ⏫ @landau_lab
Let's look at what you can do when you perform deep WGS on cfDNA for cancer detection. Our recent work with the @UltimaGenomics platform 🧵👇
Lets goooo!!
https://t.co/ZMaJqUKNDK
The integration of duplex sequencing with cost-effective Ultima sequencing enhances the accuracy of whole-genome circulating cell-free DNA profiling.
@landau_lab@AlexandrePCheng
https://t.co/irHXyJgO7X
Special nugget for my genomics friends in today's paper: Read everything but don't miss Extended Data Fig. 8, where @willbfx assembled a CCND1-ecDNA from @nanopore reads!
Excited to share "Defining heritability, plasticity, and transition dynamics of cellular phenotypes in somatic evolution", from an amazing collaboration with @landau_lab@ar_davino@TamaraPrietoF@hara_toshiro@MarioSuva!
A tweetorial, or Xplanation ...
https://t.co/i9aYCTIuO8
#NESTTrial 🪺 responses to date.🙌🏾
What’s particularly of note is the deepening of the responses with longer time to brew 🫖. The pattern🌊 and lack of recurrence speaks to curative potential of immunotherapy for both MSS and MSI-High tumors. #CRCSM@myESMO#ESMOGI24@OncoAlert
parts per million -> parts per billion -> parts per trillion? how low can we go with ctDNA detection in the era of dirt cheap whole genomes ?? .. momentous milestone by @adamjwidman@landau_lab & team👇👇👇
A major problem with cell-free tumor DNA to detect cancer (Liquid biopsy) is its very low quantity. Today @NatureMedicine use of #AI to overcome that issue with impressive results for radical signal-to-noise enrichment
https://t.co/zMWaq3F8jP
free access https://t.co/VPLpESbw3a
MRD-EDGE is out today in @NatureMedicine! Thrilled to see this in print when the future for #ctdna in plasma whole genome sequencing is brighter than ever.
An artificial intelligence-powered method for detecting tumor DNA in blood has shown unprecedented sensitivity in predicting cancer recurrence, says a team led by Dr. Dan Landau (@landau_lab) and researchers at @nygenome and @MSKCancerCenter.
https://t.co/2ZCZMnsnBG