Medsynth Group

Just great Medicinal Chemistry, since 2012!⚗️

Based at Department of Drug Science and Technology

[Medsynth Group @MedsynthG]

Last day here at #EFMCISMC22 in #nice @EuroMedChem and we have just attended Stefano Sainas' amazing talk on our first-line research project! Your team of you 🙌🏻

[Medsynth Group @MedsynthG]

That's how our VIPER project is kicked-off💪🏻😎

VIPER, the acronym for "learning a lesson: fighting SARS-CoV-2 Infection and get ready for other future PandEmic scenaRios", is a project financed by NATO - Science for Peace and Security (SPS) Programme

Stay tuned 😎

[ChemMedChem @ChemMedChem]

Time flies when you're having fun! It's the last day of @EuroMedChem #EFMC_ISMC!
We begin today w/ Prof. Stefan Knapp (@goetheuni @thesgconline @thesgcfrankfurt) on "Targeting Protein Scaffolding Function in Kinases".

@YoungSciNet #medchem #chembio #pharma #drugdiscovery #kinase

[ChemMedChem @ChemMedChem]

It's the final poster session at @EuroMedChem #EFMC_ISMC! Make sure to visit the poster area & interact w/ the presenters! Awarding of prizes sponsored by @ChemEurope, @ChemMedChem & @ChemBioChem is at the closing session at 18:05.

@YoungSciNet #medchem #chembio #pharma

[Medsynth Group @MedsynthG]

#medchem #gfactor #medicinalchemistry #spinoff

[Medsynth Group @MedsynthG]

Here, a re-cap video about the Demo Day event related to G-Factor 2021, in which our spin-off Drug Discovery & Clinics took part 💪🏻
https://t.co/qpcP4U8I8G

[Medsynth Group @MedsynthG]

#medchem #medicinal #chemistry

[Medsynth Group @MedsynthG]

Our spin-off Drug Discovery and Clinics (DDC) is on the air!
Here, the link to the full interview to prof. Marco Lolli (CEO) 👇🏻👇🏻👇🏻

https://t.co/4nejiKiApx

[Medsynth Group @MedsynthG]

Here we are at #EFMCISMC2021!
Check our worksbat the Symposium 👍🏻

[Roberto Burioni @RobertoBurioni]

OTTIME NOTIZIE: il livello di anticorpi NEUTRALIZZANTI nel sangue riesce a predire la protezione contro COVID-19. Questo significa che potremo capire meglio la durata della protezione, l'efficacia contro le varianti e sviluppare nuovi vaccini. (1/2) https://t.co/SgxaabNwv3

[Roberto Burioni @RobertoBurioni]

Quello che non tutti capiscono è che fino al 9 novembre 2020 non era per nulla scontato che un vaccino efficace fosse disponibile. Ci sono virus isolati negli anni 50 per i quali ancora un vaccino non c'è. Rendetevi conto del miracolo e soprattutto del pericolo scampato.

[Medsynth Group @MedsynthG]

The new fantastic cover for our new paper about new hDHODH inhibitors, winning the battle against AML. Artwork by Chiara Lolli.
For the cover: https://t.co/1bW7TtAtIH
For the paper: https://t.co/wBzOSH62bl

[Medsynth Group @MedsynthG]

Our new paper about new Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold has been finally published on J Med Chem!
Read it here👇🏻
https://t.co/wBzOSH62bl

[Medsynth Group @MedsynthG]

@repubblica wrote about us and our advances in anti-leukaemia and anti-vira fields!
Read more here👇🏻
https://t.co/bTBABHN4Wn

[Iole @Iole06199949]

In silico #design, #synthesis and #biological activity (enzymatic and cellular assays) of new compounds are here described.

[Iole @Iole06199949]

Here we present an improvement of the series obtained modulating the B-ring and introducing an additional phenyl (D-ring). #modelling #chemistry #research #medicinal

[Roberto Burioni @RobertoBurioni]

OTTIME NOTIZIE - Il vaccino J&J (singola dose!) è efficace all'85% nel prevenire la malattia grave ed è anche dove predomina la variante "sudafricana". Un'altra arma potentissima per combattere il virus, una notizia fantastica. VACCINIAMO! https://t.co/e6GvlNDLsh

[Iole @Iole06199949]

@DCFSCI AKR1C3 is implicated in steroid metabolism and plays a regulatory role in cell proliferation and differentiation acting as PGF synthase. Because to the close correlation between AKR1C3 and various diseases, a great deal of research on inhibitors has been performed in recent years

[Elena Martino @ElenaMartino20]

@DCFSCI
#NPCF13 #DCFSCI #CNS #INPCFMeet
P60: Bioisosteric tools to improve the solubility of our lead MEDS 433

[Iole @Iole06199949]

In the last years, our group @MedsynthG developed a series of hydroxybenzoisoxazole AKR1C3 inhibitors through the application of a bioisosteric scaffold hopping approach to the non-selective AKR1C3 inhibitor flufenamic acid. #medicinal #Chemistry #research #prostatecancer #Cancer