Mehle Lab

Our contribution to understanding influenza virus. At UW Madison. @uwmadisonMMI

[Mehle Lab @MehleLab]

@CVRHutchinson @CVRinfo @RichardJOrton @CVR_Genomics @_chris_brooke And now we're live! Open access for the final version. https://t.co/IIiHbIlv5G Thanks again @CVRHutchinson @_chris_brooke and Alistair Russell labs.

[Mehle Lab @MehleLab]

@MollyOhainle Thanks. We talked about this how many years ago? Glad we could cite your work and show how TRPPC complements your PIKA approach.

[Mehle Lab @MehleLab]

We love genetic approaches to define virus:host interactions. Knockout screens are powerful, but...technical constraints limit what you can find. Could we devise a screen where viral fitness pinpoints the key regulators of replication? (spoiler - yes https://t.co/oZrHjGuWVP) 1/10

[Mehle Lab @MehleLab]

Find more here 10/fin.
https://t.co/2Yed3bMgks

[Cell Host & Microbe @cellhostmicrobe]

Pathogen-driven CRISPR screening. @MehleLab develop transcriptional regulation by pathogen-programmed Cas9 (TRPPC) where viruses encoding sgRNAs alter host gene expression to affect their own fitness.TRPPC for influenza shows TREX1 tempers DNA self-sensing https://t.co/hzHvNEwU8q

[Mehle Lab @MehleLab]

This was the result of tenacious work and deep thinking by Cason King, and offers a legacy that reflects who he was as a scientist. I thank other lab members and our collaborators in the labs of Judy Smith and @LangloisLab, and @BWFPATH for supporting risky science. 9/10.

[Mehle Lab @MehleLab]

Bittersweet final lab meeting with Jordan Ranum (white shirt). Jordan is off to med school at UW Madison. He joined as an undergrad and stayed as a scientist. Watch out for his amazing project on defective viral genomes that is about to drop.

[Mehle Lab @MehleLab]

@_colm_ @UWMadisonMDTP 🤷‍♂️ Gotta leave something bigger for the PhD defense.

[Mehle Lab @MehleLab]

It's been a busy work for the lab. Thomas (holding 🍾) passed his @UWMadisonMDTP qualifying exam with aplomb. Very excited to see him tackle his project as a dissertator. Congrats Thomas.

[Mehle Lab @MehleLab]

Excited to announce the successful thesis defense by newly minted Dr. @graceschaack (seen riding her thesis gift, a T-Rex). Great public presentation and closed-door defense. Super proud to have her as a lab alumna, and returning to the clinic to complete her MD. Congrats!

[UW-Madison CMB @CMB_UWMadison]

Congratulations to CMB Alums, Mitch Ledwith and Dan Tremmel, the 2022 Raymond L. Erikson Exceptional Thesis Award recipients! 🎉

[Mehle Lab @MehleLab]

@alimkell @BakerLabLBRI Fascinating topic. Great to see this @BakerLabLBRI. Congrats, and perfect launching pad for your group.

[Mehle Lab @MehleLab]

@virusninja @nyuniversity Thanks Ben. Fun day with an impressive group of microbiologist and thoughtful and engaged students. Learned a lot and really enjoyed the visit.

[PLOS Biology @PLOSBiology]

Studying how #influenza virus engages the cellular environment, @bakerlabLBRI @MehleLab &co find that host cells use #AlternativeSplicing to embed #antiviral proteins in #metabolic enzymes, protecting host defenses from viral countermeasures #PLOSBiology https://t.co/rBpOgqkLY5