Meirion Raymant

Postdoc | Schmid lab | Deconstructing the functions of fibroblasts in liver metastatic pancreatic cancer | @LivUni | 🏴󠁧󠁢󠁷󠁬󠁳󠁿

[Anirban Maitra @Aiims1742]

Impressive review in @Cancer_Cell from an impressive set of authors:
Molecular phenotypes and spatial archetypes: A new framework for cancer-associated fibroblasts
https://t.co/uzHWiQdoiR
@IamLinghua @HHuanglab @MaraShermanLab @shouval @BiffiGiulia

[Michael Schmid @M_C_Schmid]

Supporting from far 👏🏻. Yuliana, a fantastic postdoctoral researcher from the Liverpool Tumour Microenvironment Team is presenting her latest findings at the AACR in Boston 🔬🧬@LivUniCancer @AinhoaMielgo @LivUniResearch

[Anirban Maitra @Aiims1742]

New preprint from @james_y_zou & colleagues @StanfordEng @EnableMedicine
ROSIE: AI generation of multiplex immunofluorescence staining from histopathology images
https://t.co/daRDNXZKhC
The #AI model here is trained on a large dataset of paired H&E and CODEX multiplex IF images.
Exciting possibilities here for sure of saving time & money on research studies, but also clinical assessments of entities that require scoring the observed grade of inflammation, or differentiating between T & B cells.

[Meirion Raymant @MeirionRaymant]

@valientelab @constanteyvital Congratulations Manuel & team!!

[Molecular & Clinical Cancer Medicine (MCCM) @LivUniCancer]

We are excited to announce our first ever MCCM Research in Action seminar, Tuesday 12th November 2024 12 noon – 1pm - postdocs & PhD students from across the department will present their work - please join us if you are able to!

[Michael Schmid @M_C_Schmid]

Fantastic ceremony today for our 2024 @LivUniCancer graduates. Congrats to our Liverpool TME PhD students @GaiaBellomo @MeirionRaymant and Patrick Freeman. Well done 👏🏻

[Meirion Raymant @MeirionRaymant]

Thanks @NorthWestCancer for a fantastic symposium & the opportunity to share our recent publication with the wider community. Very grateful for the award. Read more about our recent work here: https://t.co/RGNws9M8BR

[Michael Schmid @M_C_Schmid]

📣🔬 Thank you @NatureCancer for featuring our work on the role of efferocytic macrophages in #PancreaticCancer liver metastasis on the Cover 🤩

[Ainhoa Mielgo @AinhoaMielgo]

Fantastic talks on the role of immune cells and fibroblasts on #pancreaticCancer metastasis from several members of our Liverpool TME team and others 🤩💜

Thanks @PancreaticCanUK for organising the #PCUK2024
Great opportunity to catch up with everyone!

[Meirion Raymant @MeirionRaymant]

Looking forward to discussing ideas & establishing new collaborations at the @PancreaticCanUK Discovery and Translational Research forum today.
I will also be highlighting some of our recent work on fibroblast diversity & function in liver metastases!

[Meirion Raymant @MeirionRaymant]

👇🏻 excellent thread.

[Tanentzapf Lab @TanentzapfLab]

1. My top imaging trick to trainees is that before they spend any time taking pictures of the data they just sit there for a while & look at the stuff. Like seriously, sit back, crank some tunes, get cozy & spend some quality time with your slides.

[Michael Schmid @M_C_Schmid]

📣 Excited to share our work led by outstanding PhD student @MeirionRaymant funded by @CRUKresearch.
New insights into fibroblast heterogeneity in #PDAC metastasis.
Thanks to @AinhoaMielgo, @jen_morton, @valientelab, Neil Henderson, TME Team Liverpool. https://t.co/sr1F2q2SX4

[Anirban Maitra @Aiims1742]

From the prolific @LivUni team of @M_C_Schmid @AinhoaMielgo et al, another paper dissecting mechanistic underpinnings driving #PancreaticCancer metastasis. The authors identify four subtypes of “metastasis associated fibroblasts” or MAFs, of which hepatic stellate cell derived myMAFs play a pivotal role in the triumvirate of cancer cell, fibroblast & macrophage crosstalk. Signals from both metastatic cancer cells & macrophages (LIF & progranulin, respectively) are required to drive STAT3 dependent myMAF activation. These activated myMAFs in turn secrete osteopontin (aka SPP1), which promotes an immune suppressive metastatic milieu of macrophages, and drives cancer cell proliferation via periostin. What a complex web of interactions!!
https://t.co/vUemyn2QGL

For other recent papers by this group dissecting pancreatic cancer metastatic mechanisms just this year alone, see:
https://t.co/WJEm8fSFYf
And
https://t.co/VSrRQaYd20

[Michael Schmid @M_C_Schmid]

🤩 Excellent Cancer Seminar today presented by super ECR Yuliana Astuti discussing macrophage heterogeneity in #PDAC metastasis. Great talk and lots of exciting data! 👏🏻👏🏻👏🏻

[Ainhoa Mielgo @AinhoaMielgo]

📣💥Yuliana Astuti, a senior postdoctoral researcher from our #Liverpool TME team is speaking tomorrow at our #LiverpoolCancerSeminarSeries about her exciting work on #macrophage efferocytosis in #PancreaticCancer metastasis.
All welcome to join!

[Meirion Raymant @MeirionRaymant]

And today I’ve only gone and won the darts with my partner in crime on a beach in Cape Verde .. life does get better 😎

[Meirion Raymant @MeirionRaymant]

Thirteen years ago, to this day, I failed all four of my as level exams & thought a university education may be unachievable. Last week I successfully defended my PhD thesis! 👨🏻‍🎓

[Michael Schmid @M_C_Schmid]

👩🏻👩🏼👩🏾🧬🔬 Thank you to all female scientists in our Liverpool TME team for their key contributions to research in the #TumourMicroenvironment
#InternationalWomansDay

[North West Cancer Research @NorthWestCancer]

This #InternationalWomensDay we are celebrating our female researchers and honouring their dedication, passion, and relentless pursuit of a cure for cancer.

👩‍🔬 Swipe to read more about Dr Ainhoa Mielgos’s research 👉🏼

[Meirion Raymant @MeirionRaymant]

@Dr_SWJones There may have been some deliberate planning for this 😂

[Meirion Raymant @MeirionRaymant]

A beautiful end to the PhD studies, surrounded by all of the people that made it possible! Grateful for all of the support & very much looking forward to the next chapter ! 😁 #PhinisheD

[Michael Schmid @M_C_Schmid]

👏🏻👏🏻👏🏻Congratulations Dr @MeirionRaymant for an excellent PhD Viva today - well done! Thanx to examiners @Copple_lab and @kinasebiology. Now time to party 🥳 🍾🎉