Weilan Melo

Microbiologist at School of Pharmaceutical Sciences of Ribeirão Preto - University of São Paulo

[𝔽ℝ𝔸ℕℂ𝕀𝕊ℂ𝕆 𝔹ℝ🇧🇷🚩🧙‍♀️ @fransbras1]

🇧🇷🚩URGENTE! O mercadão de São Paulo recebendo lindamente os candidatos do Tariflávio e Tarcisio!🤪

BORA LULA!✊️

[Tabata Amaral 4040 @tabataamaralsp]

Eduardo Bolsonaro ataca a @simonetebetbr porque está desesperado. No domingo, as mulheres de São Paulo vão dar a resposta nas urnas.

[Pedro Rousseff 1️⃣3️⃣0️⃣0️⃣ @pedrorousseff]

🚨URGENTE! Jornalista AFIRMA que PLANO CONTRA Nossa Senhora Aparecida está sendo ELABORADO desde Governo Bolsonaro

A Igreja Católica estaria monitorando desde 2019 ataques de evangélicos bolsonaristas à Padroeira do Brasil.

O BOLSONARISMO QUER DESTRUIR A FÉ BRASILEIRA! 🤦‍♂️🇧🇷

[Marcelo Freixo @MarceloFreixo]

Hoje o cafezinho foi na Kopenhagen. Aceita, Flávio? Bora falar sobre suas mentiras e hipocrisia? Afinal, as denúncias do seu ex-sócio são fortes.

Federação Brasil da Esperança PT-PCdoB-PV

[Weilan Melo @MeloWeilan]

Minha mãe. Grata por qualquer ajuda🙏🏼

[Weilan Melo @MeloWeilan]

My research is available on @ResearchGate: https://t.co/hh3UCA0iwU

[Weilan Melo @MeloWeilan]

Hoje é noite de eliminação da cobra #koralconká #koralconkão

[Weilan Melo @MeloWeilan]

@vivilop Com certeza! Puxa saco dessa Koral Conka 🐍🐍🐍. #cobraKoralConka

[Weilan Melo @MeloWeilan]

Uma serpente essa #cobraKoralConka 🐍🐍🐍

[Guilherme Boulos @GuilhermeBoulos]

Defendo que a esquerda busque unidade pra enfrentar Bolsonaro. Para isso, antes de lançar nomes, devemos discutir projeto.

[PupoLab | USP-RP @PupoLab]

https://t.co/a2TQtiQS2E
A new paper came out, take a look!
Insights Into the Ecological Role of Pseudomonas spp. in an Ant-plant Symbiosis
@FukudaTaise @CamilaFiori2 @MeloWeilan @CarlaMenegatti Paulo H.M. Andrade, Milton Groppo @paulolacava @uwcurrielab @monicatpupo
(1/6)

[PupoLab | USP-RP @PupoLab]

In this new paper, we describe the research on bacteria isolated from Azteca ants that live in symbiosis with Cecropia plants (known as "embaúba" plants in Brazil). (2/6)

[PupoLab | USP-RP @PupoLab]

We observed that Pantoea, Rhizobium, Methylobacterium, Streptomyces, and Pseudomonas are the most common cultivable genera of bacteria present in this myrmecophyte interaction. (3/6)

[PupoLab | USP-RP @PupoLab]

Interestingly, Pseudomonas spp. isolates presented potent activity against 83% of the microbial pathogens tested, including a phytopathogenic fungus (Pestalotiopsis clavispora FB1) isolated from Cecropia leaves. (4/6)

[PupoLab | USP-RP @PupoLab]

The genome of one Pseudomonas strain was sequenced, and we have identified the gene cluster involved in the biosynthesis of the cyclic lipodepsipeptide viscosinamide, a known antifungal compound.
Pseudomonas strains also show the potential for nitrogen fixation. (5/6)

[PupoLab | USP-RP @PupoLab]

These strains seem to be relevant in different levels, providing nitrogen for the system and producing secondary metabolites that can inhibit the growth of potential pathogens, reinforcing the importance of these bacteria for the Cecropia-Azteca symbiosis. (6/6)

[PupoLab | USP-RP @PupoLab]

https://t.co/nkAOM6XpKe

Check out this paper we just published!
Antileishmanial macrolides from ant-associated Streptomyces sp. ISID311
@vitormargs @wildtypeMC @MeloWeilan @monicatpupo @uwcurrielab (1/4)

[PupoLab | USP-RP @PupoLab]

Studying the secondary metabolites from Streptomyces sp. ISID311 associated with Cyphomyrmex fungus-growing ants, we isolated three antifungal macrolides: cyphomycin, caniferolide C, and GT-35. (2/4)

[PupoLab | USP-RP @PupoLab]

These compounds inhibited Escovopsis, a pathogenic fungus of the fungus-growing ant system, and also exhibited antiprotozoal activity against the human parasite Leishmania donovani. (3/4)

[PupoLab | USP-RP @PupoLab]

The relative configuration of the three compounds was elucidated based on several NMR analysis and confirmed with the biosynthetic pathway proposed by bioinformatic analysis. (4/4)