Meru Sadhu

Investigator with the National Human Genome Research Institute, in the NIH. Views are my own.

[Meru Sadhu @MeruSadhu]

New from my lab: Ancestral sequence reconstruction analysis indicates the furin-cleavage-site insertion in the SARS-CoV-2 spike gene likely interrupted a codon https://t.co/yuunXxRzib

[Genetics Society of America @GeneticsGSA]

New paper in #G3journal from @mongemmmm, @MeruSadhu, and colleagues presents a barcode-based high-throughput method that can track large numbers of independent replicates of a small number of combinatorial genotypes. https://t.co/5kQ7FWTRLH

[Meru Sadhu @MeruSadhu]

I’m really rooting for this approach to catch on! Of the papers I’ve been involved in, this is probably the one I most feel is contributing a different way of thinking. Big shoutout to the co-first authors, Molly Monge (now an MD/PhD student at Cornell) and Simone Giovanetti.

[Meru Sadhu @MeruSadhu]

New paper from my lab! We describe our idea that high-throughput pooled experimental methods – typically used to test thousands of hypotheses at once – also have huge potential to help in “everyday” experiments testing one or a few focused hypotheses. https://t.co/50WVtwiy4j

[Meru Sadhu @MeruSadhu]

“High throughput” doesn’t have to mean hard/expensive! At its heart, the difference is that instead of picking a few clones of your transformation, you take all the colonies. And with low sequencing costs and the possibility of pooling sequencing, it will generally be affordable.

[Leonid Kruglyak @leonidkruglyak]

New preprint from the lab: A maternal-effect toxin-antidote element causes larval arrest in C. elegans, by @sdraljefainc et al. https://t.co/g4nCdUgT9H

[Meru Sadhu @MeruSadhu]

@leonidkruglyak @sdraljefainc Cool!!!

If the toxin is inactivated by unlinked genes in N2, then why does it exist? It won't drive. Maybe it provides viral defense, like various bacterial TA systems? (Apologies if the answer is in the paper; jumping the gun and asking questions from reading the abstract.)

[Chris MacDonald @YorkYeast]

Our obsession with yeast killer toxins was triggered by a collaboration with @MeruSadhu.

Now with @BPSIYork we have a PhD project to delve deeper into toxin effects (and defences) at the biophysical level.

Great opportunity for diverse skillsets. Apply:

https://t.co/epmNAAvBBm

[Meru Sadhu @MeruSadhu]

@arburga @IMBA_Vienna @oeaw @ERC_Research I'm late to see this, but it blew my mind when I did. Congrats!!!

[Meru Sadhu @MeruSadhu]

@MudabirAbdullah @GeneticsGSA And belated congratulations on the MERGE paper as well!

[Meru Sadhu @MeruSadhu]

@MudabirAbdullah @GeneticsGSA Congrats!

[Meru Sadhu @MeruSadhu]

@MudabirAbdullah Thanks!

[Meru Sadhu @MeruSadhu]

Now out in Genome Research! "Highly complete long-read genomes reveal pangenomic variation underlying yeast phenotypic diversity" https://t.co/JLBj61wcsk

[Meru Sadhu @MeruSadhu]

@greenkidneybean @JoshSBloom And thanks to Genome Research @genomeresearch and the anonymous reviewers - the entire process was very helpful and improved the manuscript substantially!

[Meru Sadhu @MeruSadhu]

Thanks again to Team Genome: Cory A. Weller, Ilya Andreev, Michael Chambers (@greenkidneybean), Morgan Park, Josh Bloom (@joshsbloom), and the NIH Intramural Sequencing Center

[Meru Sadhu @MeruSadhu]

Lab news: Postbac Molly Monge is headed to Weill Cornell’s MD PhD program @TriIMDPhD! Congrats, Molly and Cornell!

[Meru Sadhu @MeruSadhu]

@JulieSegre Thanks, Julie!