Metacelsus

As below, so above. I write

[Metacelsus @Meta_Celsus]

Biosecurity is good, but it's ironic that AI lab leaders are calling out biology for being potentially dangerous while rushing full speed ahead towards something 100X worse for existential risk. Where's the mandatory GPU screening and recordkeeping?

[Andrew Curran @AndrewCurran_]

Sam Altman, Dario Amodei, Demis Hassabis and many others have signed a letter urging Congress to increase security on orders of synthetic nucleic acids - and the equipment needed to make them - as models continue to become increasingly bio-capable.

[Metacelsus @Meta_Celsus]

@mbeisen @neuronsparker wait is that why ivermectin works against COVID?

/s

[Metacelsus @Meta_Celsus]

@BDR_RIKEN @embojournal Very cool paper! It does a great job uncovering a lot of interesting biology

[Metacelsus @Meta_Celsus]

@gu1dewhisperer @tbpn @AlexTISYoung Thanks for the shout-out! Anyone who's interested can learn more at https://t.co/W9SJ1FxEvc

[Metacelsus @Meta_Celsus]

Back in 1997, Teruhiko Wakayama made the first cloned mouse. Since 2005, his research group has done 20 years of continuous cloning. 58 generations, 30,947 microinjections. Here's what they found: https://t.co/dyT1lC1aX1

[Metacelsus @Meta_Celsus]

Just noticed this tag on one of my polos. Maybe @herasight should launch a fashion line...

[Metacelsus @Meta_Celsus]

@elidourado B of course, and it's not even close. Iteration time is one of our main advantages at @OvelleBio

[Metacelsus @Meta_Celsus]

Great writeup today by @eryney_ok in @corememory about our work at @OvelleBio. Anyone who's interested in solving infertility should check it out! https://t.co/sq6jyAIFK1

[Metacelsus @Meta_Celsus]

@katclone keep up the great work! I know you can do it

[Metacelsus @Meta_Celsus]

turns out Gemini's "absolute highest tier of human genomics" had a bug

"Your bioinformatic intuition is honestly incredible. You just caught a major oversimplification in the pipeline."

[Metacelsus @Meta_Celsus]

dang, Gemini keeps laying on the sycophancy:

"This is a phenomenal pivot. You have just unlocked the absolute highest tier of human genomics."

[Metacelsus @Meta_Celsus]

@davidasinclair What's with the ... unusual ... choice of Y axis scale here?

[Metacelsus @Meta_Celsus]

@BoringBiz_ Ski-U-Mah!

[Boring_Business @BoringBiz_]

Former Goldman Sachs CEO Lloyd Blankfein on hiring students from non Ivy league and prestigious schools

"The average will be higher at these great schools, and certainly the bottom quartile will be higher. But if you look at the tippy-top of Harvard and the top of the University of Minnesota, they will be at least as good. Maybe better"

[Metacelsus @Meta_Celsus]

Apparently the answer was to make a standardized Hawaiian alphabet to print the Bible . . . and also to ban hula dancing

[Metacelsus @Meta_Celsus]

Hiram Bingham I led the first Christian mission to Hawaii, and one of my ancestors. I'm reading his account and it's fascinating because he's a proto-EA!

“How shall we most effectually and most extensively promote the Redeemer’s cause with the means that are put into our hands”?

[Metacelsus @Meta_Celsus]

Hiram Bingham I led the first Christian mission to Hawaii, and one of my ancestors. I'm reading his account and it's fascinating because he's a proto-EA!

“How shall we most effectually and most extensively promote the Redeemer’s cause with the means that are put into our hands”?

[Metacelsus @Meta_Celsus]

https://t.co/gI5a4IgeVy

Nice overview of current progress and challenges in the IVG field, I'd recommend anyone who's interested to read this.

[Metacelsus @Meta_Celsus]

The biology is very interesting, especially as it relates to meiosis II, and it's a great paper. But for clinical use, I think the only way to get healthy eggs is to go through both meiosis I and II.

I wrote about their earlier (mouse) paper here: https://t.co/wKs6B6OMdz

[Metacelsus @Meta_Celsus]

Paper from the Mitalipov lab on putting skin cell nuclei into eggs. https://t.co/BI882BNLKx This causes chromosomes to segregate, sort of like meiosis II.

It's an interesting approach but one which is unlikely to lead to healthy human births. I'll explain why below:

[Metacelsus @Meta_Celsus]

Also the epigenetic imprinting will be scrambled too. Finally this method still requires a donor egg so it won't solve the egg shortage.