Michaël Chassé

Intensivist, Epidemiologist, Centre de recherche du CHUM, Associate Professor, U de Montréal, Gentleman farmer. Opinions are mine!

[Michaël Chassé @Michael_Chasse]

Thank you and Congrats @CCCTG_ for making this possible.

[JAMA Neurology @JAMANeuro]

CT perfusion and CT angiography showed less than optimal accuracy for confirming death by neurologic criteria.

#CCR25 @CritCareReviews

https://t.co/1yEsi7uik7

[Michaël Chassé @Michael_Chasse]

For the first time we have a large, prospective, multicenter, blinded, diagnostic test study conducted according to the highest methodological standards. This has not been done for any test currently in use. Although not perfect, this is high enough if applied in patients with a very high pretest-probability, but they can’t be used in replacement of a complete unconfounded bedside Death Determination by Neurological Criteria.

[Michaël Chassé @Michael_Chasse]

After 10 years, we provide updated evidence about the accuracy of CT-Perfusion and CT-Angiography for Death Declaration by Neurological Criteria, among other things.

[JAMA Neurology @JAMANeuro]

CT perfusion and CT angiography showed less than optimal accuracy for confirming death by neurologic criteria.

#CCR25 @CritCareReviews

https://t.co/1yEsi7uik7

[JAMA Neurology @JAMANeuro]

CT perfusion and CT angiography showed less than optimal accuracy for confirming death by neurologic criteria.

#CCR25 @CritCareReviews

https://t.co/1yEsi7uik7

[Critical Care Reviews @CritCareReviews]

The ninth trial result for #CCR25 in Titanic Belfast in June is the @CCCTG_ INdex Trial

CT-perfusion for the Neurological Determination of Death

Investigators - @Michael_Chasse & @shivajai1

Register at https://t.co/rPNRJVjT0r

[Michaël Chassé @Michael_Chasse]

Congratulations to a GREAT! mentor!

[The Ottawa Hospital @OttawaHospital]

“Over my career I’ve dedicated myself to optimizing the #blood products that we give patients and ensuring that they’re safe and effective.”

Congratulations Dr. Dean Fergusson on receiving a Lifetime Achievement Award from Canadian Blood Services!
https://t.co/OD5eeKBGTP

[NEJM @NEJM]

Presented at CCR Down Under:

In the SAHARA trial involving patients with subarachnoid hemorrhage and anemia, liberal transfusion of red cells did not result in a lower risk of an unfavorable neurologic outcome than a more restrictive strategy. https://t.co/WVobu2djnC

[J Gordon Boyd @jgordonboyd]

Congratulations to @shane_w_english and the rest of the @saharatrial team on publishing this work! https://t.co/pr2T4H42vz

[The BMJ @bmj_latest]

The BMJ has launched a Commission on the Future of Academic Medicine, which aims to revive academic medicine and redefine its role for the rest of the century, write @MiguelORyan1 @SoniaKSaxena and @baumfran
https://t.co/FRFM3BIFHA

[Yann LeCun @ylecun]

Yeah, really.

[Karandeep Singh @kdpsinghlab]

When ppl ask me about my priorities as a Chief Health AI Officer, I share the Health AI Paradox.

Researched models aren't implemented. Implemented models aren't researched.

My priorities are simple. Help researched models get implemented, and implemented models get researched.

[Support Our Science @SupportOurSci]

#FactFriday Did you know that Canada has the lowest spending on research and development among the #G7, with no increase in the last 20 years?

#Canada is falling behind in research and development and it's time we catch up 🕐

[Michaël Chassé @Michael_Chasse]

@JNevesBriard https://t.co/whBaEwPXCT

[Bram Rochwerg @Bram_Rochwerg]

****New Death Determination Guideline****

Developed using comprehensive GRADE methodology.

Addressing controversial areas such as,
-definition of death
-death by circulatory or neurologic criteria
-apnea testing
-ancillary testing
-legal and ethics

https://t.co/1OND2wItWJ

[Michaël Chassé @Michael_Chasse]

@Vadeboncoeur_Al @LussiD @AvecAndreFortin @vmarissal @cdube_sante @joel_arseneau Et il y a encore des soucis d’acceptabilité dans la communauté médicale. Une autre étude que nous avons faite sur le sujet au Canada: https://t.co/659Cb0WM9f

[Michaël Chassé @Michael_Chasse]

@Vadeboncoeur_Al @LussiD @AvecAndreFortin @vmarissal @cdube_sante @joel_arseneau Comme vous voyez quand cela arrive les intensivistes sont très réticents à aller à l’encontre de ces familles extrêmement éprouvées. Imaginez la catastrophe. Une équipe médicale qui va à l’encontre des désirs d’une famille en deuil? Le consentement présumé n’est pas une panacée

[NEJM @NEJM]

Observational evidence is conflicting on whether the sex of blood donors affects recipient outcomes. New findings from a randomized trial are summarized in this short video. https://t.co/54GKPXSXES

[Michaël Chassé @Michael_Chasse]

Interesting research question, but the methods used is at least as interesting. We conducted this trial with no manual data collection using ⁦@OttawaHospital⁩ and @ICES clinical/admin data. ⁦@OttawaHospital⁩ ⁦@CRCHUM⁩ https://t.co/A5xZLVhKR8

[Michaël Chassé @Michael_Chasse]

@DrToddLee @MarcCarrier1 @CIHR_ICRH @NEJM @OttMethodsCentr @OttawaHospital But if the question was not about that asymmetric distribution of the estimate but rather about the heterogeneity of treatment effect, well… this is a subgroup. Pre-specified and happens to be on our main exposure, but still a subgroup in a RCT.

[Michaël Chassé @Michael_Chasse]

@DrToddLee @MarcCarrier1 @CIHR_ICRH @NEJM @OttMethodsCentr @OttawaHospital And for those who ask about this 60:40 randomization ratio: blood supply is not even between male and female donors. So if you run a large pragmatic trial and want to have enough blood of each group you need to match the ratio with the blood supply as much as you can.