Yesokay

Boring, self-deprecatating science educator moonlighting as a situation monitor.

[Yesokay @Midwitmidwit]

@ScottPresler @JohnCornyn Fuck you, you absolute freak.

[Yesokay @Midwitmidwit]

@JohnCornyn Thank you John,

I strongly disagree with most of your political views, but I respect you because I believe you are a decent person who has Texans' best interests at heart, unlike the grifting MAGA shitbags.

[Yesokay @Midwitmidwit]

@cabsav456 Fuck you.

[Yesokay @Midwitmidwit]

@jeffersonation1 Republicans spend MORE than Democrats, start pointless wars, trample on civil liberties, protect criminals, expand the state surveillance apparatus, and demand unwaverving allegeable to their buffoon of a leader. Democrats are easily the lesser of two evils right now.

[Yesokay @Midwitmidwit]

@DrKERMD Most of these side effects can be ameliorated by slow titration schedules.

[🔰Chief Georgist Shill 🔰 @BlueRepublik]

Impeachment is not enough

The next administration must seize all Trump family assets. They have stolen too much, broke too many laws, and subverted our constitutional order

Republicans writ large must be embarrassed at the midterms, but the Trump crime family must be destroyed

[Yesokay @Midwitmidwit]

@Noahpinion Ecological and economic damage. For example the zebra mussel. @grok what's the annual economic cost of zebra mussels in the united states

[Yesokay @Midwitmidwit]

@blake41 @MartinShkreli @tunguz It's not prospective, but it needs to be investigated further in humans. There is pretty strong evidence that retatrutide suprreses tumor growth in animal models of various cancers, including those not typically associated with obesity, through multiple mechanisms.

[Yesokay @Midwitmidwit]

"A recent preclinical study by Marathe et al. evaluated pancreatic cancer endpoints in a mouse model of obesity (57). Adult male mice were given a high-fat diet and assigned to receive semaglutide, retatrutide (GLP-1R/GIPR/GCGR triple agonist), dietary calorie restriction, or vehicle control before implantation of pancreatic cancer cells. Compared with control mice fed an ad libitum high-fat diet, those receiving retatrutide, semaglutide, or calorie restriction lost significant weight, with the greatest weight loss seen in retatrutide-treated mice. Retatrutide improved body composition by reducing mass of epididymal adipose — a visceral depot in mice — while semaglutide and calorie restriction had no effect on this measure. Each intervention improved glucose tolerance. The proportion of mice with palpable tumors was lower with retatrutide, but was not substantially impacted by semaglutide or calorie restriction. The growth rate and volume of established tumors were lower in each intervention group compared with the ad libitum control, with retatrutide treatment having the greatest antitumor effect. In another cohort, retatrutide was discontinued at the time of pancreatic cancer cell implantation. This withdrawal led to weight and adipose regain, a slight increase in fasting blood glucose, and loss of the inhibitory effect of retatrutide on tumor engraftment. However, the growth of the established tumors continued to be suppressed in retatrutide-withdrawn animals. This study suggests that the mechanisms that drive the initial outgrowth of tumors from a small number of cells may not be the same as those driving the rapid growth of established tumors. Within the tumors, retatrutide increased expression of genes associated with inflammation and antitumor immunity and decreased expression of genes associated with metabolism, changes that were reversed upon retatrutide withdrawal. The investigators performed a similar experiment in obese mice with lung adenocarcinoma (57), which is not considered an obesity-associated cancer. Again, retatrutide reduced tumor engraftment rate, delayed tumor onset, and suppressed tumor growth. Consistent with data from the pancreatic cancer model, retatrutide treatment induced systemic immune reprogramming by reducing circulating CD11b+ cells, macrophages, and monocytic myeloid-derived suppressor cells, and increasing PD-1 expression in CD8+ T cells. Effects of semaglutide or calorie restriction on the immune environment were not reported" https://t.co/pXrleM7YEu

[Yesokay @Midwitmidwit]

@pearlythingz I've lost weight the hard way and it absolutely sucks keepimg the weight off. These miracle drugs allow me to free up mental compute for other tasks whe maintaining my weight loss.

[Yesokay @Midwitmidwit]

@tunguz Work in a psych hospital for a little bit and you will notice that many patients have metabolic syndrome. Of course, this is conflated by psych meds (especially antipsychotics) but many who were first time admits and untreated had metabolic syndrome.

[Yesokay @Midwitmidwit]

@tunguz All in on $LLY

[Yesokay @Midwitmidwit]

"Can you believe that a generation ago, a majority of the workforce left home at the same time to go sit in a cubicle for 8 hours a day, only to leave for home at the same time, enduring horrible traffic and risking their lives in said horrible traffic each way, hoping not to be seriously injured by other drivers, who could be any combination of sleep-deprived, emotional, intoxicated or incompetent".

[Yesokay @Midwitmidwit]

@tunguz Buildings will be required to have proper ventilation to keep C02 concentations below 1000ppm. CO2 concentations frequently exceed 4000 ppm in crowded areas, such as school classrooms.

[Yesokay @Midwitmidwit]

@ThetaEvan @AIandDesign @Meta Yes. These employees should have been living well below their means and investing aggressively. The writing has been on the wall for a while, and they were more than well compensated while they worked at Meta. This is true of all FAANG companies.

[Yesokay @Midwitmidwit]

@EricTopol This possibly explains why vaccines such as the Shingrix vaccine reduce the risk of AD. Not only can they prevent repeated or persistent viral infection of brain tissue, they can also increase immune system resiliency and potency.

[Yesokay @Midwitmidwit]

@RepDonBacon What a dumb hueristical take.

[Yesokay @Midwitmidwit]

@AlastairMcA30 @thematrixb0t Sodium

Reacts violently with water and is extremely corrosive, causing severe skin burns and eye damage.

Fatal if swallowed

But we....