Larissa Milano

[Larissa Milano @MilanoLari]

This pathway depends on BRCA1 and BRCA2 , supporting a model for RAD51-mediated daughter‑strand gap protection and/or repair occurring far behind replication forks.

[Larissa Milano @MilanoLari]

Our paper is out! https://t.co/1bivaOJFnd
We identified a role for BRCA2 in nascent strand maturation during DNA replication in the presence of PARP inhibitor.

[Larissa Milano @MilanoLari]

In this work, we show how wild‑type human cells overcome the PARP‑inhibitor–induced impediment to nascent strand maturation through a process that acts on large nascent DNA fragments and repairs thousands of olaparib‑induced single‑strand breaks/gaps per genome.

[Larissa Milano @MilanoLari]

Huge thanks to @keith_caldecott @sophiewells1007 @vaitsiankova Lylah Drummond-Clarke Xiaoxuan Zhu @auracarreiralab and Masato Kanemaki

[altmeyerlab @altmeyerlab]

A comprehensive genetic catalog of human double-strand break repair | Science https://t.co/H7vHTJ1jhJ

[Uli Rass @uli_rass]

Excited to share our latest research “DNA2 enables growth by restricting recombination-restarted replication” in @Nature defining DNA2’s essential function and elucidating links to primordial dwarfism and cancer. Thanks to the team and all collaborators! https://t.co/ngh0fabG1T

[Keystone Symposia @KeystoneSymp]

Wrapping up an insightful conference on DNA Replication Gaps, Cancer, and Disease in Daejeon, South Korea! 🎉 Congrats to our Future of Science Fund winners, Larissa Milano and Isabelle Seppa! Your achievements inspire us. 🌟 #KSDNARep25 @CantorLab @CicciaAlberto

[Hana Sedlackova @HanaSedlackova1]

📢 For all DNA fiber enthusiasts! 🟥🟩 We are thrilled to announce the release of our long-awaited AI-based workflow for the automated and quantitative analysis of DNA fibers. It's an exciting step forward—check it out on bioRxiv! https://t.co/N643U0oS1M

[Sara Gutiérrez-Enríquez @SaraGutierrezEn]

Functional evaluation and clinical classification of BRCA2 variants | Nature https://t.co/zsksALtSoH

[Ann Cirincione @AnnCirincione]

Thrilled to see our work out in @naturemethods today! We applied prime editing to multiplexed dropout screens and benchmarked the tool’s ability to induce phenotypes when installing premature stop codons in essential genes.

[Dr. Luke A. Yates @Yates_luke]

🚨 We are looking for a new cryoEM 🔬 facility manager @SussexUni This is fantastic opportunity to work with leading researchers (like us @GDSC_Sussex) who want to observe the molecules of life and better understand human disease.

https://t.co/WG1pLoWaEO

[Zha Lab @zha_lab]

New Paper from the lab is now published on Mol Cell! https://t.co/rLWkPKr84w
The paper showed that inactive PARP2 dose-dependently blocks DNA replications of erythroblasts and causes lethal anemia. Congratulations to the first author, Xiaohui Lin! He is on the job market.

[Rebeca Olvera-León @RebecaOLE_]

Beyond excited to share that my first-author paper on Saturation Genome Editing of RAD51C is now published in @CellCellPress! Immensely proud of this enormous team effort, led by Andrew Waters and @David_J_Adams 1/8

https://t.co/m62qZjLKl9

[Cancer Research UK @CR_UK]

The cost of visas for scientists at our research institutes is set to rise by 44% in a year. This will discourage scientists from coming to work in the UK and take vital funds away from our life-saving research. We’re calling on the new government to make its #First100Days a #TurningPointForCancer, including by reviewing visa fees for scientists.

Find out more 👉 https://t.co/pojIZltJWL

[Juan A. Rodríguez @jrotwitguez]

It’s finally out! 🥳 Today @cellcellpress we report non-mineral fossils of ancient chromosomes in skin from a woolly mammoth that died in Siberia, 52,000 years ago.
🦣💨
Don’t miss our thread below! 🧵👇🏽

[Wellcome @wellcometrust]

New analysis from the @royalsociety shows just how high UK visa costs for researchers are compared to upfront costs for similar visa routes in 13 other countries.

Here, we take a look at how the UK compares to countries in the G7 included in the analysis 🔍⤵️ 1/5

[Keith Caldecott @keith_caldecott]

Dear all, here is a new paper describing some of Sophie’s lovely PhD work on KU80-binding motifs (KBMs) and replication stress. It’s very interesting (he said, totally unbiased)!

https://t.co/HIw8Up6870

[Danielle Beckman @DaniBeckman]

Many people have no idea how these things work.

For example, right now, as a Brazilian, I can't accept invitations to speak at conferences in Europe because my visa to work in the U.S. has expired.
I am not illegal; I have a work contract with the University of California until 2027. Still, I must travel outside the U.S. and get a visa stamp on my passport to allow me to move freely to talk about science.
I have to do this every single year I stay in the U.S. The costs of the visa, traveling, time lost, etc, are all on me. Not every international scientist can handle this.

[Bo Xia @BoXia7]

A true curiosity-driven journey, fulfilling one of my childhood dreams! The tail loss marks a pivotal evolutionary step towards humans and apes. But how did it happen? https://t.co/jTcOAH0Fcs @ItaiYanai @JefBoeke