Eric Taylor

Professor and Principal Investigator, Molecular Physiology and Biophysics | Faculty Director, Metabolomics Core. Carver College of Medicine, U of Iowa.

[Eric Taylor @Mitoverse]

1/n. Final version now online @MolMetab! Especially for labs newer to metabolomics, we hope this clarifies the need to freeze tissues immediately after loss of perfusion to preserve the in vivo metabolism. https://t.co/XAWVUAUkKF

[Eric Taylor @Mitoverse]

Ever wondered how quickly mouse tissues need to be frozen to preserve the in vivo metabolome? Immediately after disrupted perfusion. We show here that this applies to the broad metabolome, between-genotype differences, and 13C-isotopologue distributions. https://t.co/7Sbuq6q6og

[Eric Taylor @Mitoverse]

@cholsoon_jang @Sunhee_Jung_ @HosungBae @NatMetabolism Congrats all, a beautifully solved puzzle!

[Adam Rauckhorst @adam_rauckhorst]

Thrilled to share that I’ve joined @FIU and the @FIU_CTS in Port St. Lucie as an Assistant Professor! Excited to kick off this new chapter in research, collaboration, and mentoring.

#NewFaculty #FIU #TranslationalScience #AcademicTwitter #ResearchLife

[Eric Taylor @Mitoverse]

@Denis_V_Titov @RobertoZoncu @ChoeMangyu Great to see this out Denis!

[Ashutosh Mangalam @Ashu_Mangalam]

We r excited to announce the publication of our work in PNAS! This work, which began in early 2017 @uiowa with recruiting MS patients & HC, sheds new light on the critical role of the gut microbiome in MS #microbiome #MultipleSclerosis #symbiont 1/n 🧵 https://t.co/HilBo5CguI

[Rutter Lab @RutterLab]

Hello everyone! I am helping to organize a one-day symposium on fluorescent metabolite biosensors and their use in metabolism research. It will be May 12-13 and associated with the Cold Spring Harbor Laboratory “Mechanisms of Metabolic Signaling” Symposium. Our field needs to be able to visualize metabolism with spatial and temporal resolution and this symposium will explore what to do and how to do it, with experts in metabolism and biosensor development and use. Please join us! https://t.co/8QfiKTCeDs -JR

[Eric Taylor @Mitoverse]

Thanks also to co-authors @adam_rauckhorst, Michael Chimenti, Tayyab Rehman, Henry Keen, and Phil Karp

[Eric Taylor @Mitoverse]

How do cells respond to physiologically high O2 levels? In research just published in Science Advances (https://t.co/YOCXfGpFER), we investigating respiratory epithelia since their contact with air exposes them to some of the highest O2 levels in the body.

In work led by @B581434 (Bo Ram Kim) and co-corresponding with Mike Welsh, we show that basal airway stem cell mitochondria signal high O2 levels via mitochondrial citrate export.

High O2-induced mitochondrial citrate export leads to selective histone acetylation and differentiation into ciliated airway cells, which are critical for clearing mucus and pathogens from the lungs. Our findings may inform mechanisms to enhance lung airway repair after injury or treat other conditions where the number of ciliated cells is insufficient.

[Harpreet Singh ਹਰਪ੍ਰੀਤ ਸਿੰਘ @HSingh_OSU]

Thanks to @nih_nhlbi for the direct support for the project and highlighting the publication. Read behind the paper story at Discovery of the first functional ion channel in extracellular vesicles. https://t.co/rhA5o6r06t #exosomes #ionchannels

[Eric Taylor @Mitoverse]

Have you ever wondered how mitochondrial and cytosolic pathways for de novo lipogenesis (DNL) interact?

We did!

Published Online today (https://t.co/l05A4qyCx1) and led by first-author @adam_rauckhorst, we traced 13C-labeled lactate/pyruvate, acetate, the ketone acetoacetate, and leucine in several mouse models of disrupted hepatic mitochondrial and cytosolic acetyl-CoA generating pathways.

Surprisingly, deleting the mitochondria citrate carrier (CiC) increased DNL from both exogeneous and leucine-generated acetoacetate. Overall, our findings delineate a mitochondrial-cytosolic DNL substrate supply network that may guide more accurate therapeutic development for MASLD and T2D.

Many thanks to our expert collaborators: No X Ryan Sheldon, now leading metabolomics at the @VAInstitute, who helped start the project and develop the necessary mass spec methods with @adam_rauckhorst; for @StanislawDeja and @Isotopomer for deuterium tracing by NMR and careful contibutions to quantitatively framing our mass spec data; and Tom Vallim of @TarlingVallim for guidance with in vivo gene deletion by AAV CRISPRs.

Please also see the exciting co-published manuscript from @WellenLab and Christian Metallo Labs (https://t.co/Wq1JH6AXZS) showing that bempadoic acid does more than just inhibit ACLY!

@FOEDRC, @UIowaResearch, @UIMolecPhysBio

[Eric Taylor @Mitoverse]

The truly immersive John Luther Adam’s Inuksuit!

Performed by 100+ percussionists at Iowa City’s City Park, with Hancher Auditorium. @HancherUI @CityOfIowaCity @IowaCityofLit

[Eric Taylor @Mitoverse]

G3 storm arriving with lights likely most visible Saturday. #aurora #northernlights #spaceweather #iowa

[CBS Philadelphia @CBSPhiladelphia]

The northern lights could be seen as far south as Iowa, Oregon and Pennsylvania, according to the Space Weather Prediction Center.https://t.co/hyQXEFCv4Y

[Sarah Wernimont @sawernimont]

So grateful for support of @RsdpScholars @umnmedschool and many mentors and colleagues who helped get this far! I’m excited to keep doing science with a great team. #teamplacenta

[Eric Taylor @Mitoverse]

@sawernimont @RsdpScholars @umnmedschool Congrats Sarah!

[Eric Taylor @Mitoverse]

@ThePlanetaryGuy Amazing!

[Eric Taylor @Mitoverse]

@HSingh_OSU Congrats Shridhar and Harpreet!

[Eric Taylor @Mitoverse]

@nadmullin @jclinicalinvest Great work!