Miyuki

2nd year PhD student at the University of Tokyo, directed evolution of microalgae, wastewater treatment

[Miyuki @MiyukiXu]

@DanYuan20 @SerendipityWrk Yes, we can find a morphological indicator following the same process for Ag and Hg.

[Miyuki @MiyukiXu]

My #SerendipityPoster about an intelligent morphological indicator of Cu2+ removal efficiency that can be used for the directed evolution of microalgae towards enhanced heavy metal removal capability.
@SerendipityWrk
#UniversityOfTokyo #SerendipityWorkshop2020
#SW_Microbiology

[Miyuki @MiyukiXu]

@uuyonihsoh @SerendipityWrk @nukkie66 This is a completely new concept for me. Very interesting! Will the plastic antibodies be used in human body? Are they non-toxic and biodegradable?

[Miyuki @MiyukiXu]

@JeffHarmon05 The classification accuracy is really high. Cool! Why do you choose 6 species? How many species should be classified for practical use?

[Miyuki @MiyukiXu]

@etayyabi @SerendipityWrk Thank you for your good idea.

[Miyuki @MiyukiXu]

@etayyabi @SerendipityWrk For Cu, it can not reach nM level, because cells are not sensitive to Cu in that low concentration. Maybe a combination with deep learning will help to lower the detection limit.

[Miyuki @MiyukiXu]

@etayyabi @SerendipityWrk Yes, it is possible for other heavy metals. I also found similar morphological response of E. gracilis to Ag and Fe using imaging flow cytometry. I think it maybe also possible for Pb.

[Miyuki @MiyukiXu]

@JGaladePablo @SerendipityWrk There may be multiple mechanisms involved in this process, like cell wall binding, vacuole sequestration, molecule complexation, etc. We hope to collaborate with professional microbiologists to figure it out in the future.

[Miyuki @MiyukiXu]

@JGaladePablo @SerendipityWrk The cells go into a cellular shape because they are stressed. But I have not made it clear why the stressed cells have better ability to remove copper ions.

[Miyuki @MiyukiXu]

@DanYuan20 @SerendipityWrk Nice work! I noticed that the flow rate is pretty low. Is there any method to greatly improve it?