maurizio molinari

Cell biologist, Mechanistic dissection of protein folding, quality control, degradation, UPR, and ER-phagy pathways. Non sono direttore di giornale. My opinions

[maurizio molinari @MolinariLab]

News on ERLAD: Calnexin:FAM134B:VAPA:ORP1L:RAB7 contact site between ER and endolysosomes to remove misfolded proteins.
CNX:FAM134B-driven ERLAD of ATZ polymers proceeds via enhanced formation of VAPA:ORP1L:RAB7 contact sites between ER and endolysosomes https://t.co/auNUg5jtgZ

[maurizio molinari @MolinariLab]

Today’s NCB. The cytoplasmic intrinsically disordered regions (IDRs) of ER-phagy and mitophagy receptors are interchangeable, required and sufficient for the ER and mitochondria fragmentation required for lysosomal clearance of the organelle’s portions.
https://t.co/MK6dTmBNgD

[maurizio molinari @MolinariLab]

Selective autophagy of organelles: the “disorder” is key. Intrinsically disordered regions of organellophagy receptors are interchangeable, required, and sufficient for organelle fragmentation and lysosomal delivery … and all about ORGATACs 😉
https://t.co/mmRyB6jfk8

[maurizio molinari @MolinariLab]

ATZ polymers elicit intervention of the CNX:FAM134B-LC3II segregation complex and formation of VAPA-ORP1L-RAB7 membrane contact sites that facilitate Syntaxin18/VAMP8-driven fusion of ER and endolysosomal membrane: ER-to-Lysosome-Associated Degradation.

https://t.co/oOiszevEiU

[maurizio molinari @MolinariLab]

I would like to warmly thank the ALPHA-1 Foundation for the important support allocated to our research project “Understanding the Molecular Mechanisms of Lysosomal Clearance of ATZ Polymers".

A1F recognizes 2025 Grant Award Recipients during ATS  https://t.co/8oeAYN3kuo

[Nature Reviews Molecular Cell Biology @NatRevMCB]

New Online! Key challenges and recommendations for defining organelle membrane contact sites https://t.co/ZGhjrQsQzC

[maurizio molinari @MolinariLab]

@lab_cali @NatRevMCB Nice!! Very useful!!

[Calì_Lab @lab_cali]

🚨 New review out in Nature Reviews Molecular Cell Biology!
Expert recommendations for studying organelle contact sites and introduce the concept of organelle contactome 🧬https://t.co/8gWJlHFAgN
Huge thanks to editor Lisa Heinke for the support and guidance! 🙏@NatRevMCB

[FC Lugano @FCLugano1908]

📼 ⏮️ 𝑯𝒆'𝒔 𝑩𝒂𝒄𝒌!

Bentornato a casa Gjanni! 🤍🖤

#noibianconeri #fclugano #lugano

[maurizio molinari @MolinariLab]

Early morning discussion about see turtles with Jeff Brodsky. FASEB Endoplasmic Reticulum meeting, Melbourne, Florida.
⁦@FASEBorg⁩

[maurizio molinari @MolinariLab]

Dan, a friend for many of us, passed at the end of last year. Before leaving, with his students and colleagues, he prepared this gift. Amazing. N-glycan-dependent protein maturation and quality control in the ER | Nature Reviews Molecular Cell Biology https://t.co/aB1CB178x4

[maurizio molinari @MolinariLab]

For Dan! https://t.co/74EJSmr5bi

[maurizio molinari @MolinariLab]

Two structurally targeted allosteric regulators of GCase folding promote lysosomal transport of disease-causing variants, reduce ER stress and rescue lysosomal functions. Therapeutic potential for GD, PD, and Dementia with LB.
https://t.co/QSEd33yJkd #mdpiijms via @IJMS_MDPI

[maurizio molinari @MolinariLab]

Uncovering ERLAD: the ER-to-Lysosome Associated Degradation of large, aggregated, disease-causing, nasty misfolded proteins that fail to enter proteasomal-driven ERAD pathways.

https://t.co/JTQieDa6wD

[Alpha-1 Foundation @AlphaFriend]

We’re proud to share that the Alpha-1 Foundation has been named one of the 2025 Best Nonprofits to Work For by @NonProfitTimes ! This recognition reflects our ongoing commitment to fostering a mission-driven culture that values collaboration, innovation, and impact. Read more: https://t.co/Z5J4FFCMsy

[Alpha-1 Foundation @AlphaFriend]

We wish you and your loved ones a happy and meaningful Easter. 💐

[Alpha-1 Foundation @AlphaFriend]

Alpha-1 doesn’t just affect the lungs, it can impact the liver, too. On #WorldLiverDay, we’re shining a light on Alpha-1 liver disease and the importance of early diagnosis and support. To learn more about Alpha-1 and the liver, visit: https://t.co/URpegVwAcH #Alpha1Awareness

[maurizio molinari @MolinariLab]

Dreams …

https://t.co/khU56Jvlxi

[Kamil Tamiola, PhD @KamilTamiola]

For those new to scientific research, please remember that the only thing that matters is the REPRODUCIBILITY of your study, not the impact factor or journal name. Thank you.

[maurizio molinari @MolinariLab]

@weldeiry @AMCuervoLab @EinsteinMed @WeillCornell ER-phagy is missing from the slide 🤭