We developed mice in which brain autophagy — the cell's "cleanup" system — can be switched on and off. Even after neurons deteriorate, restarting autophagy restores cellular "quality" and function. Neurons may stay resilient even under pathology.
https://t.co/flEKUmmCZe
Our new paper is out in @ScienceMagazine! We developed mice with reversible control of autophagy, and showed that restoring this pathway after its suppression reverses neuronal abnormalities and brain dysfunction, demonstrating the resilience of neurons. https://t.co/kegmU08mcY
Autophagic flux measurement: cargo degradation versus generation of degradation products.
The advantages of quantification of degradation products in the evaluation of autophagy activity were explained.
https://t.co/9W8QKCdoQX