Autophagic flux measurement: cargo degradation versus generation of degradation products.
The advantages of quantification of degradation products in the evaluation of autophagy activity were explained.
https://t.co/9W8QKCdoQX
We simulated the formation of OPTN droplets on the membrane in mitophagy.
The droplets could lead to the membrane connection.
Autophagy adaptors mediate Parkin-dependent mitophagy by forming sheet-like liquid condensates | The EMBO Journal https://t.co/45fTEIfgJp
Noboru shows a 'MD simulation'. ATG9 vesicles move freely due to thermodynamic fluctuations. When they contact the OPTN droplet in the center of the screen, the ATG9 vesicles are captured and anchored to the droplet due to the wetting effect (Mizushima et al. unpublished)
Noboru shows a 'MD simulation'. ATG9 vesicles move freely due to thermodynamic fluctuations. When they contact the OPTN droplet in the center of the screen, the ATG9 vesicles are captured and anchored to the droplet due to the wetting effect (Mizushima et al. unpublished)
Our new paper has been published in @embojournal! We demonstrated that capillary forces by autophagy receptor droplets on mitochondria is important for mitochondrial recognition and mitophagy. Congratulations, Zi!
https://t.co/WyEV1zO0of
Our new paper has been published in @embojournal! We demonstrated that capillary forces by autophagy receptor droplets on mitochondria is important for mitochondrial recognition and mitophagy. Congratulations, Zi!
https://t.co/WyEV1zO0of