We’ve also released the mCanonicalTockySeq R package! 📦💻
It reconstructs temporally resolved developmental state spaces by integrating Tocky signalling history into scRNA-seq workflows.
https://t.co/GoC8G0LLb2
Delighted to share our new bioRxiv preprint:
https://t.co/Frc6kIYb0q
We present mCanonicalTockySeq, which uses the Nr4a3-Tocky system to anchor single-cell transcriptomes in experimental time, allowing resolution of time-dependent thymic development in both mice and humans.
We’ve also released the mCanonicalTockySeq R package! 📦💻
It reconstructs temporally resolved developmental state spaces by integrating Tocky signalling history into scRNA-seq workflows.
https://t.co/GoC8G0LLb2
Delighted to share our new bioRxiv preprint:
https://t.co/Frc6kIYb0q
We present mCanonicalTockySeq, which uses the Nr4a3-Tocky system to anchor single-cell transcriptomes in experimental time, allowing resolution of time-dependent thymic development in both mice and humans.
Delighted to share our new bioRxiv preprint:
https://t.co/eF7ujfGWZh
We present a new approach to resolve T cell temporal states at single-cell resolution in cancer immunotherapy.
My thanks to all co-authors and collaborators.
#Immunology#CancerResearch
I am pleased to share the release of CanonicalTockySeq: Canonical Tocky Analysis for Temporal Gradient on a Transcriptomic Manifold.
This package provides tools for analysing temporal gradients on transcriptomic manifolds within the Tocky framework.
https://t.co/iRHTE9nu3i
Delighted to share our new bioRxiv preprint:
https://t.co/eF7ujfGWZh
We present a new approach to resolve T cell temporal states at single-cell resolution in cancer immunotherapy.
My thanks to all co-authors and collaborators.
#Immunology#CancerResearch
Honoured that our T-cell immunotherapy research is featured in The Telegraph via Cancer Research UK. Using Tocky, we reveal the behaviour of therapy-responsive and anti-cancer T cells, aiming to further improve immunotherapy approaches to melanoma.
https://t.co/smvDMZhYDe
Honoured that our T-cell immunotherapy research is featured in The Telegraph via Cancer Research UK. Using Tocky, we reveal the behaviour of therapy-responsive and anti-cancer T cells, aiming to further improve immunotherapy approaches to melanoma.
https://t.co/smvDMZhYDe
🚀 Thrilled to share our new paper using Deep Learning and Tocky!
https://t.co/YAQepboYJs
👉 We build on our original Tocky method by integrating CRISPR & deep learning to decode transcriptional dynamics.
🔥 7 years of work - toward data-driven immunology!
🚀 New paper out!
Our ConvNet + Grad-CAM approach decodes Fluorescent Timer (Tocky) data at single-cell resolution.
Using Foxp3 Tocky, we reveal CNS2-controlled and developmental transcriptional dynamics.
Built on 7 years of work with AI and CRISPR!
https://t.co/YAQepbpwz0
Bored of black-box UMAP and clustering in #Cytometry?
GatingTree skips such methods, directly analyses high-dimensional data, builds reproducible tree paths across markers, and reveals group-specific effects.
No dimensionality reduction, just interpretable gates. 🌳
🚀 Our next-generation cytometry tool GatingTree now published in #CytometryPartA!
🔗 https://t.co/P8M5xlgcnY
GatingTree enables systematic analysis of high-dimensional flow cytometry data, without relying on dimensionality reduction. 💻
Bored of black-box UMAP and clustering in #Cytometry?
GatingTree skips such methods, directly analyses high-dimensional data, builds reproducible tree paths across markers, and reveals group-specific effects.
No dimensionality reduction, just interpretable gates. 🌳
🚀 Our next-generation cytometry tool GatingTree now published in #CytometryPartA!
🔗 https://t.co/P8M5xlgcnY
GatingTree enables systematic analysis of high-dimensional flow cytometry data, without relying on dimensionality reduction. 💻
Dr. @masahirono (@imperialcollege, UK), together with Dr. Nobuko Irie, Dr. Naoki Takeda, @Sato_Y_Lab, and Prof. Kimi Araki, has unveiled a machine learning-powered method to decode transcriptional dynamics using a Fluorescent Timer system.
@NatureComms, https://t.co/PL68uYCLUx
Plz RT. We are looking for a postdoc to join our collborative project on AI-guided bioengineering of plant immune receptors
@Tolga_Bzkrt
and
@JiorgosKourelis
labs: https://t.co/HipazXeyiI