Morten Hansen

PhD in Immunology and a passion for vaccination approaches and Immuno Oncology. Senior Scientist and Lab Manager at @CCITdk

[Morten Hansen @MortenCCIT]

@KatieMiller Dear Katie
Greenland is way over your league. I hope you will eventually understand this.

[Jesper Møller Sørensen 🇩🇰 @DKambUSA]

With all due respect @SenTuberville - you simply got this wrong. You have to revisit your facts on Greenland, including what the people want.

It is not respectful to send a delegation of senior officials at this time, when the Greenlandic politicians say that they do not want this visit.

And by the way - Greenland is very good for your health!

[Waggoner Lab @LabWaggoner]

Atlas of the immune system development in the fetal blood
https://t.co/Sksjb4WoKh

[Waggoner Lab @LabWaggoner]

Outstanding info graphic from @NersesianSarah visually and factually consolidating the information from recent NK/ILC diversity studies in @NatImmunol !

[Jay Bhattacharya @DrJBhattacharya]

Prof. @StabellBenn is a brilliant Danish vaccine epidemiologist. Her ideas about the non-specific effects of vaccines led her to research the impacts of the covid vaccines with many surprising results. Listen to our Illusion of Consensus interview 👇
https://t.co/ju11nJVBO2

[Samuel Hume @DrSamuelBHume]

Glucocorticoids (GC), like dexamethasone and prednisolone, are widely used in medicine, but how do they actually work?

This is really impressive work (Auger et al.), which figured it all out

There are two mechanisms: a slow, broad response, which depends on transcriptional changes by the glucocorticoid receptor (GR)

And a second, fast (but sustained) response, where GCs increase flux through macrophage TCA cycles to produce the metabolite, itaconate:
Itaconate was produced systemically in response to GCs, and quickly reduced inflammation through a range of mechanisms

Here's the most interesting bit: GCs only suppressed inflammation if the TCA cycle and itaconate were in tact, but this was mostly independent of GR's broad transcriptional response - suggesting that the TCA/itaconate pathway is predominant

A possible consequence of this: some of the side-effects of glucocorticoids in patients, like increased fat mass and type 2 diabetes, may result from GR's broad transcriptional changes...

... so if we had more precise drugs, which exploit the itaconate response but spare the GR response, this could decouple the beneficial (anti-inflammatory) effects of steroids from the negatives

Here it is: https://t.co/91IJGhgXy9

[Asgard Therapeutics @AsgardThx]

#Asgard announces €30 million Series A financing! Funds will be used to support development of our lead program, AT-108, as well as expanding Asgard's R&D team to further develop AT-108 and broaden our in vivo reprogramming #pipeline.

Read the PR in the link in the comments.

[Christine Stabell Benn @StabellBenn]

Bente Klarlund beklager her fokus på at behandle diabetes/overvægt, fremfor at skabe rammer, der gør det nemt at leve sundt.
Som min gamle svenske vejleder sagde: Vi ska inta titta på "risk faktorer", men "frisk faktorer".
Det betaler sig.
https://t.co/nY2dZL57TK

[Vinay Prasad MD MPH @VPrasadMDMPH]

Looking forward to giving the keynote tomorrow @Stanford
On what COVID19 taught us about the academy

[Morten Hansen @MortenCCIT]

https://t.co/UBvvaW1iSa

[Vinay Prasad MD MPH @VPrasadMDMPH]

Glad this article is reaching so many

[Morten Hansen @MortenCCIT]

@DoniaMarco @EvaEllebaek @OliviaKaas @CCITdk @DoniaMarco this is such an important study. Would be great if you could work with non-melanoma clinicians and compare with other indications and learn where aPD1 adds the most value in real world settings

[Morten Hansen @MortenCCIT]

@CKjersgaard Ser frem til en spændende dag, fedt koncept.

[Marco Donia @DoniaMarco]

#Melanoma at #ESMO23:
Unprecedented response rates in patients with uveal melanoma treated with a combo of TKI.
❕ORR 30%
‼️1. Line: ORR 45%
@myESMO #melsm

[Katalin Kariko @kkariko]

Nobel Prize winner Katalin Karikó was 'demoted 4 times' at her old job. How she persisted: 'You have to focus on what's next' https://t.co/6YplV89RE3

[Arianna Draghi @AriannaDraghi]

🔬 Great talks from two great scientists! I highly reccommend taking the time to listen to this inspiring mini-symposium on evidence-based clinical cancer immunotherapy 💡

[Marco Donia @DoniaMarco]

All you need to know about Evidence in Cancer Immunotherapy. Now online, free at https://t.co/bahG3BhfQu

Thanks to the outstanding speakers @VPrasadMDMPH and @Alfdoc2, to @CCITdk @HerlevGentofte, and @koebenhavns_uni to make this happen!

[River Parrish @RiverParrish1]

A hiking buddy of mine who had noticeably and suddenly stopped doing the more strenuous 14,000ft hikes a couple of years ago called me and made a confession:

He got myocarditis from his second mRNA shot. Listening to him describing being alone on a trail run and suddenly having chest pains and trouble breathing was horrifying. He was afraid he was going to die alone. He's a marathoner and highly active, in his mid 30s.

The worst part:
He was afraid to tell me or anyone in his friend group.

His literal quote:
"I saw how Oz [his best friend] and especially his fiance [a med school graduate in residency who is super attached to the establishment covid narrative] were talking about the antivaxxers, and I felt like if I talked about it with any of them, I would have hurt Oz's relationship. I also felt like Kristen [a mutual friend of ours] would have judged me and stopped hanging out. I just kept it quiet. But yeah man, I'm still having a hard time with the 14ers, and my run times are all way down."

This is a photo of him (on the left, not showing his face out of respect for his privacy) on our last hike where we were only at 10,000ft altitude, and at the time I had noticed he was struggling, but when we asked him about it, he said he was "hungover". He wasn't. It was about 10 month after the myocarditis, and he was hiding it from us.

Self-censorship is perhaps the most horrifying aspect of this. None of us should find out years later that our friends had to be hospitalized. The fact that he felt he had to hide it is horrifying.

He is an incredibly smart and driven guy, and he bluntly told me that he "knows, deep down, that if I said anything about this publicly, I'd be flushing my career down the toilet. I work in the software industry in Boulder. I know what will happen if I say something."

When I told him that I believed him, and told him about my mother-in-law and my neighbor, he obviously felt a huge sense of relief. He was afraid that I was going to judge him for the crime of telling me about a medical side-effect.

Ironically, his first job out of college was working for a pharma company, specifically on a new statin. His description of the science on statins, and the things they were and were not allowed to study on statins, was horrifying. His exact words, which echoed what I've heard @BretWeinstein say:
"Working there, the entire culture is so messed up man. Like, the way they think is 'we're going to market this, now you go and make sure we can get it approved, and it was obvious that without studying anything, they already were making it clear that we WILL get it approved, and your job is to make sure you design the studies to make that happen.' Dude, they don't care about people at all. It's just numbers to them."

What have we done? There needs to be a reckoning for the regulatory capture of the CDC/FDA, and the current administration's obviously political taint to the approval process. The current booster that the US is pushing on the age group 6 months and up is only approved for those over 65 in the UK and Europe. There is no scientific explanation for this discrepancy. There is something wrong.

@DrJBhattacharya

[Vinay Prasad MD MPH @VPrasadMDMPH]

Anyone who wants to listen to this talk can do it online. Still open.

[Morten Hansen @MortenCCIT]

Really a great presentation by @SpitzerLab on how immune responses to cancer immunotherapy occurs outside of the tumor

https://t.co/ZDe9pfOF7l