MPC Therapeutics

MPC Therapeutics is a biotechnology company focused on cellular rejuvenation to fight cancer & degenerative pathologies

[Global Corporate Venturing @GCVenturing]

Could you tap into the #mitochondria, rejuvenating cells, to improve #immunotherapy and treatments for other diseases like #alopecia? @MpcTherapeutics, spun out of @sciences_UNIGE / @unige_en, says yes. CEO Raphaël Martinou tells @GUVenturing more https://t.co/tpxn8iMtWR

[MPC Therapeutics @MpcTherapeutics]

@KnoblochLab @FBM_UNIL Congratulations!!

[MPC Therapeutics @MpcTherapeutics]

Thanks @KnoblochLab for highlighting the findings of @PhDPetrelli's @ScienceAdvances paper, a collaboration with Prof. Jean-Claude Martinou, our CSO.

[Marlen Knobloch @KnoblochLab]

Finding #4: Surprisingl, MPC knockout NSPCs can generate fully mature neurons. These data show that NSPC progeny display high metabolic flexibility.

[Marlen Knobloch @KnoblochLab]

Finding #3: The inhibition of pyruvate transport into mitochondria leads to an intracellular increase of aspartate, which is sufficient to trigger NSPC activation.

[Marlen Knobloch @KnoblochLab]

Finding #2: The import of pyruvate into mitochondria is necessary to maintain the quiescence of NSPCs. Deletion or inhibition of MPC in quiescent NSPCs triggers their activation.

[Marlen Knobloch @KnoblochLab]

Finding #1: Quiescent neural stem/progenitor cells (NSPCs) have an active mitochondrial metabolism and express high levels of mitochondrial pyruvate carrier (MPC).

[MPC Therapeutics @MpcTherapeutics]

#justout: Our CSO's latest article in @ScienceAdvances : "Mitochondrial pyruvate metabolism regulates the activation of quiescent adult neural stem cells." #MPC #mitochondria #StemCells
-> https://t.co/67tZWqQpQG

[MPC Therapeutics @MpcTherapeutics]

@Novartis announced their T-Charge platform preserves #Tcell #stemness : the ability to self-renew and mature, resulting in a product containing greater proliferative potential and fewer exhausted T cells. #CARTcell #cancer #immunotherapy #celltherapy https://t.co/kiD73BqDQz

[MPC Therapeutics @MpcTherapeutics]

@HubUnige @sciences_UNIGE thank you for your support

[Venture Kick @venturekick]

CHF 1.5 million for powering up T cells to fight cancer: @UNIGE_en spin-off MPC Therapeutics raises seed round to advance its program into the clinic by 2024. Kudos to biotech entrepreneurs Raphaël Martinou and Jean-Claude Martinou!
https://t.co/uI8t30YbEt
#VentureKick #Biotech

[MPC Therapeutics @MpcTherapeutics]

@venturekick @unige_en @UNIGEnews @HubUnige @unige_int @grstiftung_ch thank you for your support!

[MPC Therapeutics @MpcTherapeutics]

#breaking #PressRelease : MPC Therapeutics Announces Completion of Its CHF 1.5M Seed-Funding Round to Improve CAR-T Cancer Therapies
#mitochondria #CARTCell #Tcells #Stemcells
https://t.co/pscl3lO8Af

[Iñigo San Millán @doctorinigo]

The mitochondrial pyruvate carrier (MPC) was discovered just 10 years ago but it is going to become a major player in health and disease. https://t.co/f7SbimZyOB

[Marlen Knobloch @KnoblochLab]

https://t.co/HFabKv2Xmq

Very excited to share our study on bioRxiv on how mitochondrial pyruvate metabolism regulates quiescent adult neural stem cells. #stemcells #mitochondria #metabolism. Great collaboration with @JCMartinou. Huge congrats to @PhDPetrelli @Val_N_Tina01!!

[Mitochondrial Medicine @Mito_Therapy]

A very interesting and exaustive review (2018) about multifaced contribution of mitochondria to cellular metabolism by @JessicaSpinel16

https://t.co/VFRyyGl3fe

[Oncology UNIL CHUV @OncoUNILCHUV]

NEW STUDY on the regulation of memory T cell differentiation & antitumor function through the mitochondrial pyruvate carrier @Cell_Metabolism.

#CancerResearch by @MathiasWenes (now @unige_en) & Pedro Romero @unil @CHUVLausanne, with @MiglioriniDenis.

📑https://t.co/D8HOlU0ifr

[MPC Therapeutics @MpcTherapeutics]

@MathiasWenes Congratulations Mathias for this huge achievement ! This is only the beginning of an exciting journey !