Severe COVID-19
A 2025 meta-analysis pooling data across 10 independent studies confirmed:
F. prausnitzii depletion: logFC = -1.24 (95% CI -1.68 to -0.80)
Translation: It was significantly lower in every severe COVID cohort analyzed.
The more depleted. The sicker the patient.
F. prausnitzii is one of the most abundant bacteria in a healthy human gut.
It produces butyrate — a molecule that:
• Fuels your colon lining
• Seals your gut barrier
• Suppresses inflammatory signals
• Regulates your immune system
When it disappears, all of that fails at once.
BREAKING 🧵
A gut bacterium is showing up — or rather disappearing — across all three phases of COVID-19.
Severely ill patients have less of it.
Recovered patients get it back.
Long COVID patients don't.
Its name is Faecalibacterium prausnitzii. And what it does explains a lot. 👇
Estudian la sangre de personas con Covid persistente y encuentran estructuras anómalas que no deberían estar ahí | Fernanda Tapia https://t.co/Kv7dqcBDZm
Un equipo internacional de 60 expertos de 10 países, con participación destacada de investigadores de la REiCOP (@_REiCOP), ha publicado la primera guía internacional de práctica clínica centrada en la prevención y tratamiento de la #COVIDPersistente en adultos.
Prospective associations of long COVID with sleep health nearly 3 years after SARS-CoV-2 infection: a statewide representative cohort study https://t.co/dbAsD4iJPQ
Un nuevo estudio analizó a 2.406 adultos con infección confirmada por #SARSCoV2 en una cohorte representativa del estado de Michigan y encontró que la #COVIDPERSISTENTE se asocia con problemas significativos de sueño incluso casi 3 años después de la infección.
Este artículo de autores de la United Arab Emirates University, colaboradores de India, Reino Unido y otros centros, te puede interesar ya que reúne en una sola figura varios de los mecanismos biológicos que hoy tienen más respaldo para explicar el COVID persistente.
Va hilo🧵
🧠 La gravedad de la niebla mental se correlacionó con la afectación vascular de la circulación posterior, sugiriendo que cuanto mayor era la alteración arterial, más severos eran los síntomas cognitivos.
🧠 Las personas con niebla mental o cefalea persistente mostraron más alteraciones arteriales cerebrales que los controles.
🧠 Quienes tenían tanto cefalea como niebla mental presentaban las alteraciones más marcadas.
Utilizaron angiografía por resonancia magnética (MRA) para evaluar el estado de las arterias cerebrales mediante una escala cuantitativa de gravedad llamada FCASS.
Hallazgos principales
Este estudio del 13 de junio de 2026 aporta una pieza muy interesante al rompecabezas del #LongCovid neurológico: la posible participación de una arteriopatía cerebral (alteraciones en las arterias del cerebro) en la niebla mental y, en menor medida, en la cefalea persistente.
Happy to share that after a prolonged peer-review process, our review covering the major Neuroinflammatory events in #LongCovid was accepted today for publication at @Transl_Psych from the @NaturePortfolio! Coming soon, but preprint available here: https://t.co/Pa1ME9eRpT
Dynamic changes in cardiac autonomic function persist in the post-acute phase after SARS-CoV-2 infection in a hamster model of COVID-19
🚨IMPORTANT, AUTONOMIC DYSFUNCTION!
Human studies have shown observational links between Long COVID and autonomic dysfunction. This new USA hamster model study adds CAUSAL evidence and TEMPORAL data, proving the dysfunction evolves dynamically and does not resolve!
Model:
- Syrian hamsters intranasally infected with SARSCoV2
- Continuous telemetry ECG monitoring of heart rate and heart-rate variability (HRV) at multiple time points (acute, recovery, and post-acute phases, weeks after viral clearance).
Main finding:
A. Infection triggers a triphasic pattern of cardiac autonomic dysfunction:
-1. Acute sympathetic hyperactivation,
-2. Transitional shift, and
-3. Persistent dysregulation that continues long into the post-acute phase,
B. HRV parameters remained significantly altered weeks after the virus was undetectable, showing ongoing imbalance in sympathetic/parasympathetic control,
C. No direct viral persistence in the heart, yet autonomic signalling stayed disrupted,
D. Preliminary data implicate oxidative stress pathways as one potential driver.
As far as I know, this is the first robust preclinical animal model to demonstrate dynamic, time-dependent, and long-lasting cardiac autonomic changes directly caused by SARSCoV2!
‼️So, SARSCoV2 doesn’t just cause a temporary “flu,” it leaves the heart’s autonomic nervous system permanently rewired. Long COVID dysautonomia is real, a measurable biology, not anxiety or deconditioning. This hamster model proves the damage persists and evolves even after the virus is gone and gives us researchers a candidate focus needed to finally fix it.
‼️“Inhibition of innate immune activation or mitochondrial oxidative stress during the acute phase prevents the autonomic dysfunction in the post-acute phase, offering a potential strategy to mitigate long COVID syndromes.”
‼️In short: it moves the LC field from “we see it in patients” to “here’s how and why it lasts!”
#LongCovid #Dysautonomia #AvoidSars2 #AvoidReinfections
https://t.co/YfFUgA7YIC
🧠 El cerebro continúa mostrando señales de COVID Persistente: el PET con 18F-FDG detecta alteraciones metabólicas asociadas a fatiga y malestar post-esfuerzo (PEM).
🧵#COVIDPersistente#LongCOVID#PEM#Disautonomía#Neuroinflamación https://t.co/58XVjbvzFp