Mummery Lab

Cardiovascular development & disease | Stem Cell Biology | Cardiac Organoids | Organ-on-Chip | @GlobalLUMC| @RENEW_Global. Tweets by group members.

[Mummery Lab @MummeryLab]

🚨Preprint alert!
STRAIGHT-IN Dual allows the generation of homogenous genetically-modified hiPSCs
▪️ Done in 1 week with ~100% efficiency
▪️ Markerless and near-scarless approach performed in >10days in a single-well
▪️ Carrying not one but two (single-copy) payloads
See🧵below!

[Katie Galloway @GallowayLabMIT]

So you want to engineer your hiPSCs, but targeting DNA payloads requires multiple slow, inefficient steps for each construct. What if we could accomplish multi-site integration seamlessly?
🚨Introducing STRAIGHT-IN Dual! 🧵 (1/n)
Link: https://t.co/4BKAf4Or90

[Katie Galloway @GallowayLabMIT]

Could the folding of synthetic gene circuits in 3D shape how genes are expressed? Today @ScienceMagazine we report on the role of gene syntax in shaping feedback between transcriptional activity and genome folding for advanced circuit design🧵 (1/n)

[Albert Blanch Asensio @A_BlanchAsensio]

Our STRAIGHT-IN Dual platform is officially out at @natBME 🔥🚀

A big step forward for programmable stem cell engineering — faster, cleaner, and more versatile.

Link📰: https://t.co/uQp7urNFKq

Don’t miss the 🧵 from the one and only @GallowayLabMIT breaking it all down 👇

[Albert Blanch Asensio @A_BlanchAsensio]

🚨We have updated our STRAIGHT-IN Dual preprint!
🧵with all the details in the comments (1/n)
Link: https://t.co/X7r5V9TPfl
@GallowayLabMIT @nbwang22 @BenBlakeleyJ @annionna

[Katie Galloway @GallowayLabMIT]

How do cells transit from fate to fate? Quietly.

@MITChemE

[Albert Blanch Asensio @A_BlanchAsensio]

New career goal unlocked:

✅ Attending the #SynBio24 conference with my twin brother @marcblanch94.

Thanks @GallowayLabMIT @billerbeck_s @ProfTomEllis and Yasunori for the amazing program and opportunity to present my last preprint STRAIGHT-IN Dual ⬇️
https://t.co/E1u0dh3Sq1

[Mummery Lab @MummeryLab]

artxscience 2024 #5 - reNEW
Vote for picture #5. ⁦@BenBlakeleyJ⁩ https://t.co/RvyHyt4OVS

[Joram Mooiweer @JoramMooiweer]

What characteristics should an MPS have to be useful for modeling human phenotypes?

In this review, we (mainly @dennisnahon & @MoerkensRenee) created a reference for quantifiable 'design' and 'emerging' MPS features to compare to real human settings.

https://t.co/t6F0L0w1Bq

[Ben Johnson @BenBlakeleyJ]

Super thrilled to be part of the reNEW #ARTxSCIENCE competition! Choose your favorite image (obviously mine 😉) showing some exciting new work happening with another postdoc and myself! https://t.co/9AI0LHyjWy

#LUMC @MummeryLab #cardioid #confocal #stemcell
#cardiac

[Albert Blanch Asensio @A_BlanchAsensio]

Extremely happy to see the protocol manuscript for the STRAIGHT-IN platform out online and featured as protocol of the week @NatureProtocols.

[reNEW @reNEW_Global]

Join Professor Christine Mummery (@MummeryLab), #reNEW Leiden @LUMC_Leiden, for a panel discussion at #ISSCR2024 on 'Use of Standards for Stem Cells in Non-Clinical Research' on Fri 12 July, 1.30pm-3.00pm CEST in Hall G2, Level 2.

[Albert Blanch Asensio @A_BlanchAsensio]

Happy to see our work highlighted at The Scientist magazine.

Targeted Gene Integration for High-Throughput Applications
https://t.co/8SLSqX46ez

[Jim Wells Lab @JimWellsLab]

Kicking off the last session of Day 1 #ISSCRCincy is @MummeryLab with a fantastic update on her work on hpsc-derived cardiovascular tissue to study disease. @ISSCR

[reNEW @reNEW_Global]

We are pushing stem cell research further than ever before. Meet Professor Christine Mummery. Her work focuses on understanding cardiovascular development and disease mechanisms.​

All reNEW researchers are leaders within their field, with a strong track record of scientific excellence. Together, they work to turn their research into real therapies that improve the health of people around the world.

See full video: https://t.co/qxbvmfDnm3

@GlobalLumc @MummeryLab @MCRI_for_kids @UCPH_Research #stemcellresearch #stemcelltherapies #cardiovasculardevelopment

[reNEW @reNEW_Global]

Congratulations to postdoc Ben Johnson, from the Richard Davis and @MummeryLab at reNEW Leiden for receiving a prestigious Marie Curie fellowship. Ben will use the fellowship to develop a stem cell based model for myocardial infarctions. Read more:
https://t.co/bgQf3np9H6

[Katie Galloway @GallowayLabMIT]

Delighted to welcome Albert Blanch Asensio @A_BlanchAsensio as a visiting student with our lab! Albert pioneered STRAIGHT-IN with Richard Davis and @MummeryLab. We're excited to build circuits in these landing pad iPSC lines!
https://t.co/xbAd7hABnM

[Human Technopole @humantechnopole]

🧐 #MeetTheSpeaker!

🔬 @MummeryLab @LUMC_Leiden explores the potential of #iPSCs in disease modeling. From mimicking patient mutations to screening for drugs, the goal is to create a population study for personalized medicine.

https://t.co/fyPhnJm4Un

[Cell Reports @CellReports]

Perlecan (HSPG2) promotes structural, contractile, and metabolic development of human cardiomyocytes https://t.co/6YH87agOKE

[Ben Johnson @BenBlakeleyJ]

Thrilled to be awarded the NWO-XS grant to generate an inducible heart attack stem cell model in a fantastic lab! ⁦@MummeryLab⁩ ⁦@reNEW_Global⁩ https://t.co/WWG6SdBktU

[Dr. Sara Nunes Vasconcelos (she/her) 🇨🇦🇧🇷 @YYZscientist]

The true #vascular meets #cardiac: it's going to be an awesome conference! Looking forward to it.
Mark your calendars!🗓️
#Cardiovascular
@UofT_LMP @bme_uoft @UHN_Research @TGHRI_UHN @vascularbiology