Claudio Musetti

MD, nephrologist
PhD in Clinical and experimental medicine
Lions Club Novara Ovest Ticino charter member

[Claudio Musetti @MusettiClaudio]

@HecmagsMD Is it LFT, creatinine, electrolytes and proteins? Guess about 100 euros in Italy if paid outside the national health system. That would probably be 200$ + tip as US are about twice as expensive. Not sure tho if healthcare is affected by your tipping culture

[Claudio Musetti @MusettiClaudio]

@TheLancetRheum @fairvasc @Vasculitis_Lund I love cluster analyses, but I wonder if this stratification better predicts survival than a stratification by severity of kidney involvement or by disease activity (ie bvas)

[Claudio Musetti @MusettiClaudio]

@HanCardiomd @WilfriedMullens @FH_Verbrugge @AndrewJSauer @markcpetrie20 @CMichaelGibson @mmamas1973 @mvaduganathan @ShelleyZieroth @hvanspall @AmrAbdin10 It looks like acetazolamide didn't add much in this trial, or am I missing something?

[Claudio Musetti @MusettiClaudio]

@WilliamAird4 The gentic iron deficiencies are rare, but yet underdiagnosed (as far as I recall): how (and when) do you test patients for these conditions?

[Claudio Musetti @MusettiClaudio]

@HanCardiomd @JACCJournals @ACCinTouch @AHAScience @ShelleyZieroth @ShelleyWood2 @mmamas1973 @AkhmetzhanG @gbiondizoccai @DrMarthaGulati @JamalRanaMD Nice work👍🏼 do you have any potential explanation for the effect on sudden cardiac death? May be related to a lower potassium? Or a higher magnesium? Other ideas?

[Claudio Musetti @MusettiClaudio]

@edgarvlermamd @CJASN @neilturn @IgAN_JBarratt RaDaR cohort: Was hematuria addressed in this cohort? Could persistent (micro)hematuria stratify the risk in "low risk" pts?

[Claudio Musetti @MusettiClaudio]

@frank_dor @BTStransplant What if the same candidate has had a pediatric onset srns that responded to rituximab and has been in remission for more than 5 years?

[Claudio Musetti @MusettiClaudio]

@frank_dor @BTStransplant Agree, but some concerns on (as for most donors under 25): future health (ie: pregnancy) or renal (ie: fam history of adult onset nephropathies) issues and their awareness, evaluation of psychological maturity/overall awareness, social aspects.

[Claudio Musetti @MusettiClaudio]

@drgarethroberts Vegetarian and vegan diets were barely used in uk prior 2010 and now uk is the country with most vegans/vegetarians
Not a great source, but still... https://t.co/wMDixcsBl5

[Claudio Musetti @MusettiClaudio]

@Proximal_Baxi @askrenal It might also depend on the type of surgery (how much blood loss/potassium elevation in theater), the chances of going to postOp-ICU anyways and the available options to lower rapidly the potassium (ie: renal function, availability of lokelma vs only possibile with dialysis)

[Claudio Musetti @MusettiClaudio]

@IDdocAdi If you wanna hear some screams, try a creatinine1.3-costume in radiology

[Claudio Musetti @MusettiClaudio]

@carlitosrojasq @saugarmaripuri Wasn't dr House a nephrologist? Too long ago?

[Claudio Musetti @MusettiClaudio]

@NephroGuy @BryceBarr9 @GlassockJ @Ask_Renal Rebiopsy for sure if feasible. Might look for collagen mutations or other "phenocopies".
If active and no major controindications I would evaluate with them the option of steorids/IS. This does not look like a typical "trial" patient to me

[Claudio Musetti @MusettiClaudio]

@KSusztak I know this was not the aim of the study, but... Was there any episode of severe, acute hypotension (ie sepsis) and how did treated pts go? The long biological effect is wonderful in terms of compliance but may not be completely safe in specific situations

[Claudio Musetti @MusettiClaudio]

@Renaltubules Agree on no biopsy in steroid sensitive (8 wks in adults? Up to 16?). Biopsy if partial remission or on relapse, esp if within 1 year.
Partially agree on genetic studies (how fast will they be?), but biopsy first if aki, high risk of NS complications, MM/MGUS or hematuria

[Claudio Musetti @MusettiClaudio]

@kirylukk @NatureGenet @ColumbiaKidney Very nice work, I'm gonna read it in the next few days/weeks.
Just out of curiosity: did you include familial IgAN cases/families? If so, how much did they influenced the results? Or they had different susceptibility loci? Thanks in advance!

[Claudio Musetti @MusettiClaudio]

@priti899 @Ask_Renal @PanktiMehta24 @nihardesai7 @AdamRodmanMD @GlomCon @thisis_drgsp @arvindcanchi @aishaikh @nickmmark @GlassockJ Cyclophosphamide more "commonly" induces ungueal discolouration/melanonychia (first report I guess in the 70s). Also the melanosis of tongue and ellbows has been described.

[Claudio Musetti @MusettiClaudio]

@priti899 @Ask_Renal @PanktiMehta24 @nihardesai7 @nihar_nayak2 @AdamRodmanMD @GlomCon @thisis_drgsp @arvindcanchi @aishaikh @nickmmark @GlassockJ How much steroid does he assume during cyc? Might be related to an increased acth? Not very common, but worth checking

[Claudio Musetti @MusettiClaudio]

@PD_Perls @Ask_Renal @PD_Perls @Ask_Renal : very few trials, this (https://t.co/XXqAmj8k8f) is one of the largest and found a thrombosis rate of about 3/100 pt-yrs in pts with sglt2i-erythrocytosis. Not much, but might be worth checking and take action at least for very high ht values (>54% maybe?)

[Claudio Musetti @MusettiClaudio]

@brian_rifkin Not for rookies, but along with a dialysis what about kidney transplant or kidney-pancreas transplant?