Nature Chemical Biology

A scientific journal devoted to publishing the most compelling research, opinion and analysis at the intersection of chemistry and biology.

[Nature Chemical Biology @nchembio]

Our June issue is live with a focus on RNA chemical biology

https://t.co/XnR4xoRqal

The cover image depicts the ribozyme SAMURI, which catalyzes transfer of alkyl groups from SAM to a specific adenosine in target RNA, represented as igniting a chemical spark

[Nature Chemical Biology @nchembio]

Oxygen-dependent and photoreactive APEX2-based proximity labeling using a chemically evolved biotin probe for applications in living cells and in vivo

https://t.co/HHi4Nn31yV

[Nature Chemical Biology @nchembio]

A new Review on using large-scale glycomics to understand glycan function #glycotime

https://t.co/TbHIULD2Y2

[Nature Chemical Biology @nchembio]

A new Perspective details the current bottlenecks and outlines a research roadmap in biocatalytic nylon recycling

https://t.co/lveWlVyXaj

[Nature Chemical Biology @nchembio]

The editorial highlights RNA breakthroughs in this issue

https://t.co/w2uCdipqYw

and a Q&A with Maria Duca, Samie Jaffrey, and Ling-Ling Chen discusses challenges and opportunities in RNA-centered therapeutics

https://t.co/PzOz5W3sWJ

[Nature Chemical Biology @nchembio]

Our June issue is live with a focus on RNA chemical biology

https://t.co/XnR4xoRqal

The cover image depicts the ribozyme SAMURI, which catalyzes transfer of alkyl groups from SAM to a specific adenosine in target RNA, represented as igniting a chemical spark

[Jun Qi Lab @JunQiLab]

Our collaborative work with @IrenemGhobrial on targeting transcription factor IRF4 is now online @nchembio. It is so exciting that we discovered an IRF4 binder & a selective IRF4 degrader that can interrupt MM cell growth. Congrats @10mM_Mike & all authors https://t.co/RJFu6wqJsU

[Nature Chemical Biology @nchembio]

A genetically encoded peptide inhibitor of mTORC1 is developed and reveals that nuclear mTORC1 regulates a specific set of genes and promotes cancer cell proliferation

https://t.co/QeQEkolstR

[Nature Chemical Biology @nchembio]

The potency of a class of RAF kinase inhibitors is found to depend on cancer cell signaling activity, and MEK inhibitors can be reengineered to sensitize RAF kinases to inhibitors for synergistic RAF-MEK inhibitor combinations

https://t.co/1m5SMPWP0C

[Nature Chemical Biology @nchembio]

A new series of covalent, monovalent glue degraders can co-opt two E3 ligases, DCAF16 and FBBXO22, in a parallel fashion to degrade SMARCA2/4 with chemically and genetically tunable ligase preference

https://t.co/azG0RCPFTt

[Nature Chemical Biology @nchembio]

A new platform screens for and enables the design of peptide biosensors of dysregulated proteolytic activity in tumors for tumor detection and therapeutic development

https://t.co/Ob7CGEcX3w

[Nature Chemical Biology @nchembio]

A bioorthogonal, clickable dopamine probe enables chemoproteomic mapping of dopaminylated proteins, revealing a role for histone H4 dopaminylation in cell growth

https://t.co/RC4W6noLFf

[Chris Parker @_chrisgparker_]

Happy to share the final version of this work is now out in @nchembio. Lots of additional exciting data! Congrats to all the authors!

https://t.co/r61jFJjJq4

[Nature Chemical Biology @nchembio]

Our May issue is live!

https://t.co/i8r9ZUPpXi

The cover image depicts the vulnerability of the non-transcribed strand of genes to oxidized guanines and abasic sites

[Nature Chemical Biology @nchembio]

A new Perspective discusses recent developments in RNA modifications on chromatin-associated RNAs, how they modulate chromatin states, and future direction for studying RNA regulatory elements to control gene expression

https://t.co/a2tMAH02ra

[Nature Chemical Biology @nchembio]

A condensation-independent intramodular translocation mechanism in trans-acyltransferase polyketide synthases

https://t.co/tdpf3nPjdh

[Nature Chemical Biology @nchembio]

A cell-permeable nanobody stabilizes misfolded F508del cystic fibrosis transmembrane conductance regulator (CFTR) and restores CFTR activity

https://t.co/wdENRPjM2O

[Nature Chemical Biology @nchembio]

Hypocrealean fungi form symbiotic relationships with plants while antagonizing pests. A survey of 5221 of their biosynthetic gene clusters reveals that ~80% encode unknown products, which could have potential for pest control

https://t.co/NSKjU6voy4

[Nature Chemical Biology @nchembio]

A tubulin isotype-modulated allosteric network governs paclitaxel-binding affinities and affects paclitaxel efficacy against cancer cells

https://t.co/DknfC05Ujj

[Nature Chemical Biology @nchembio]

Illuminating microtubule architecture – Check out the associated News and Views by Rūta Gerasimaitė Gražvydas Lukinavičius

https://t.co/U5TWjQMkPi

[Nature Chemical Biology @nchembio]

CenSpark is a dual-ligand fluorescent probe simultaneously binding inner and outer microtubule sites – a configuration unique to doublet and triplet microtubules, enabling selective live imaging of centrioles and cilia across species

https://t.co/ncTWrxELeY