NIASCEND 👽

WHERE THE FLUSH ENDS
🎈THE ASCENT BEGINS
🛸 🚀

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@Kdndem9 @s6berr https://t.co/c0YkNl0ow6 yourself…

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@FpLiOnYkD__ @DefiantLs Why do you just assume he’s gonna live longer though?

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@zazaxbtt This is their “evidence”?

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@zazaxbtt And they still mortal and aging

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@AndyAudio8 @DawnsMission that is the point - so they don't and believe them into harm

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"In the presence of adequate nicotinic acid maximum growth was obtained when DL-tryptophan constituted 0.2%, or more, of the diet."

QUANTITATIVE DL-TRYPTOPHAN REQUIREMENT OF THE WEANLING PIG

D. C. SHELTON, W. M. BEESON & E. T. MERTZ

Purdue University

https://t.co/GNZgeuf0st

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@SunnyT44321328 @jakeglmn Why the common “alternatives” don’t work — and often cause harm

1. “Just eat more meat” does not fix the problem

Dietary tryptophan from protein is protein-bound, not free.

Under metabolic stress (dieting, inflammation, obesity), tryptophan is preferentially diverted into...

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@SunnyT44321328 @jakeglmn Dieting reduces plasma tryptophan and alters brain 5-HT function in women

https://t.co/X9hejrncsH

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"Since disturbed Trp affects biosynthesis of serotonin and might be associated w/ susceptibility for mood disturbances and carb craving, strategies to supplement Trp while dieting could be highly useful in treating uncontrolled weight gain or preventing neuropsychiatric symptoms"

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@SunnyT44321328 @jakeglmn Effects of a caloric restriction weight loss diet on tryptophan metabolism and inflammatory biomarkers in overweight adults | European Journal of Nutrition
https://t.co/oXJXNg5OcJ

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The potential role of niacin (vitamin B3) in rheumatic diseases

https://t.co/q90lvnvDLk

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“The nicotinic acid GPR109A receptor regulated the structure of the gut microbiota & that the microbial populations were different between WT and Gpr109a- mice. Bacteroidetes & Firmicutes

These findings indicate that GPR109A regulates the gut microbiota”

https://t.co/5j9AvbIpYD

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@0interestrates @cremieuxrecueil “Antibiotics” were “shown” during PELLAGRA from niacin/tryptophan-deficient diet, NOT “infectious” disease, to “improve” growth by frying intestine freeing tryp to compensate for niacin’s lack — as “evidence” from thereon that rebranded Nazi war agents kill fabricated “pathogens”

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"In the presence of adequate nicotinic acid maximum growth was obtained when DL-tryptophan constituted 0.2%, or more, of the diet."

QUANTITATIVE DL-TRYPTOPHAN REQUIREMENT OF THE WEANLING PIG

D. C. SHELTON, W. M. BEESON & E. T. MERTZ

Purdue University

https://t.co/GNZgeuf0st

[NIASCEND 👽 @NIASCEND]

RHEO

"Despite tremendous efforts, effective pharmacological agents for the treatment of obesity are still limited. Here, we showed that in contrast to lactate receptor GPR81, niacin receptor GPR109A-deficient mice had progressive weight gain and hepatic fat accumulation. Using..

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high-fat diet-induced mouse model of obesity, we demonstrated that niacin treatment apparently protected against obesity without affecting food intake in wild-type mice but not in GPR109A-deficient mice. Further investigation showed that niacin treatment led to a remarkable..

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inhibition of hepatic de novo lipogenesis. Additionally, we demonstrated that niacin treatment triggered brown adipose tissue and/or white adipose tissue thermogenic activity via activation of GPR109A. Moreover, we observed that mice exposed to niacin exhibited a dramatic..

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decrease in intestinal absorption of sterols and fatty acids. Taken together our findings demonstrate that acting on GPR109A, niacin shows the potential to maintain energy homeostasis through multipathways, representing a potential approach to the treatment of obesity, diabetes..

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and cardiovascular disease."

Niacin fine-tunes energy homeostasis through canonical GPR109A signaling

https://t.co/feHuGcKqCE

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and cardiovascular disease."

Niacin fine-tunes energy homeostasis through canonical GPR109A signaling

https://t.co/feHuGcKqCE

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RHEO

"Despite tremendous efforts, effective pharmacological agents for the treatment of obesity are still limited. Here, we showed that in contrast to lactate receptor GPR81, niacin receptor GPR109A-deficient mice had progressive weight gain and hepatic fat accumulation. Using..

[NIASCEND 👽 @NIASCEND]

decrease in intestinal absorption of sterols and fatty acids. Taken together our findings demonstrate that acting on GPR109A, niacin shows the potential to maintain energy homeostasis through multipathways, representing a potential approach to the treatment of obesity, diabetes..