Why?
It is totally unacceptable that you continue approving products without specifically studying MITOCHONDRIAL vulnerable patients.
Did COVID vaccine associated myocarditis teach you nothing?
adults 50 and older...a population with extensive chronic illness, polypharmacy, and potentially unrecognized mitochondrial dysfunction.
Where are the subgroup specific safety data for patients with primary mitochondrial disease, respiratory chain complex deficiencies, acquired drug induced mitochondrial dysfunction, dysautonomia, ME/CFS, POTS, PEM or polypharmacy involving medications with known mitochondrial liabilities?
The concern is not that vaccine mRNA enters the nucleus or becomes mitochondrial DNA. It is released into the cell’s cytosol, where ribosomes translate it into influenza antigen.
But antigen production, protein processing, innate immune signaling, inflammatory regulation, cellular repair, and recovery all place metabolic demands on the cell. (ie mitochondria) What happens with dysfunctional mitochondria? There are 200+ medications that cause mitochondrial vulnerability.
Now place severe Complex I deficiency into that pathway. Which I posit majority of FQAD patients exhibit.
So what happens when that compromised system is suddenly asked to support from a mRNA vaccine:
increased protein production,
immune signaling,
redox control,
inflammatory resolution,
cellular repair,
and ATP demand?
The question is not simply: “Is this safe?”
The question is: Where are the targeted safety data for people whose mitochondria are already dysfunctional as in FQAD?
Drug-safety frameworks routinely scrutinize genotoxic risk to nuclear DNA, yet mitochondrial toxicity - despite affecting an organelle equally essential to cellular survival - receives no comparable standardized scrutiny before approval or through pharmacovigilance.
I am not claiming that every adverse event will be mitochondrial or telling everyone to reject vaccination. I am asking questions that the FDA and researchers should be asking. I am asking why mitochondrial status, respiratory-chain function, bioenergetic reserve, and prior exposure to medications with known mitochondrial liabilities are not specifically measured when evaluating new biological stressors. Especially with 200+ medications that can cause mitochondrial vulnerability!
Mitochondrial dysfunction patients deserve targeted research, honest disclosure of what remains unknown, and an individualized risk-benefit discussion with their physicians.
They deserve to be studied before postmarketing surveillance is left to discover whether a signal exists.
Approve it first and then “watch for signals” is not precision medicine.
Identify vulnerability before exposure.
Measure it.
Disclose the uncertainty.
Track outcomes longitudinally.
https://t.co/oSl7OWf4Pw
@haveaconcern I finally quit after going back and forth with HR in emails for 8 months. My boss called the next day and gave me a 5 figure severance and unemployment. I sold all my investment properties and my own home - left the state and moved on.
Russell Fry LOVES gas taxes!
So much so, 12 cents per gallon you are paying right now is because he helped push that raise through in 2017.
Looks like ole Rusty has a touch of the RINOvirus™️.
@AniSigmaWalker@lee92579@DailyLoud Yes it is - when the young die suddenly at numbers like recently and didn’t before the vax it most certainly is a conspiracy.
@ibleed_ep@lee92579@DailyLoud Ok we will just sit back shut up and continue to watch the vaxxed die suddenly- because we should grow the fuck up right jerk? We are not dying suddenly - get that through your thick skull.
@RobertKennedyJc@Letty_bug89 I watched the interview- her knowledge of all aspects discussed was embarrassingly ignorant and to cover she used juvenile responses like “I’m not going to debate you” lol. CNN should fire her