What if you could deliver molecular tools directly into oocytes without microinjection? In our new paper, online today @Dev_journal (https://t.co/ryxCG1MVKy), we introduce VitelloTag, a new cargo delivery tool to enable injection-free genome editing. 👇Read on for a short 🧵
Chromatin scientists, want to reorganize genomic loci as you wish?
Out today in Cell--We made a tool that uses surface tension of engineered condensates to reposition DNA loci across microns of space in living cells in just a few minutes: VECTOR https://t.co/914xsicfcV
Kudos!👏 to Harsha Sen, 3rd-year grad student in @R_Mallarino lab, awarded Best Student Talk in Division of EvoDevo Bio at 2024 meeting of Society for Integrative and Comparative Biology #SICB2024. The talk: "Molecular evolution and development of the mammalian gliding membrane."
A clever strategy for multiplexed immunolabeling out today from Peng Yin's lab. "Thermal-plex" uses DNA probes that fluoresce sequentially when, and only when, activated with transient exposure to heating spikes at designated temperatures. https://t.co/OilK0wX7NT
New paper alert! Working with @CALM_STP @TheCrick@Princeton we have developed a method to stage zebrafish embryos using deep learning 💻📷 Many thanks to my co-authors David Barry and Matt Renshaw, as well as @veni_menon,@rburdine1@glaevsky and Danelle Devenport 💙
Very happy to have this research project from my postdoc with @EKfarley out in Dev Cell!
We wondered if single-nucleotide variants within heart enhancers can affect enhancer activity and phenotype.
Delighted to share our new pre-print and introduce the mTurq2-Col4a1 mouse model in which collagen IV is endogenously tagged - thanks to all authors! A Window into Mammalian Basement Membrane Development: Insights from the mTurq2-Col4a1 Mouse Model https://t.co/gs4PHbmREg
So excited to join the Dept of Biochemistry & Molecular Biophysics @ColumbiaBiochem and the Program for Mathematical Genomics!!! I am extremely grateful to Stavros and many others for the warm welcome, and greatly looking forward to learning, discussing & collaborating together.
Delighted to share a short review article published in @ScienceAdvances!!
Enhancer dynamics: Unraveling the mechanism of transcriptional bursting.
https://t.co/2z8ZoW6brn
How do distal enhancers control transcription dynamics in living cells? Check out our latest work published in @MolecularCell!! We show that the dynamic assembly and disassembly of TF clusters at enhancers are a major source of transcriptional bursting. https://t.co/vpOSWJAfBq
In this study, @NicholasTreen et al. describe a temporal transcriptional switch in the chordate embryo, regulated by FGF signaling. Read more about it here:
➡️https://t.co/fxvl76qc0q
Happy to announce publicly that I was awarded a K99/R00 from NCI! Big thanks to Proud Cliff Brangwynne @brangwynnelab and my co-mentor on this project Cigall Kadoch @CKadoch
Looking forward to big discoveries!