Nima Nasiri

Organic chemist | PhD @ScrippsResearch, @BaranLabreads | Total synthesis & synthetic methodology | ETH Zürich & Sharif alum

[Baran Lab @BaranLabReads]

Stop sampling accessible isomers. Start building the target matrix.

Saturated heterocycles bearing covalent reactive groups already appear in more than a dozen FDA-approved medicines, including ritlecitinib and ibrutinib, making systematic exploration of this space directly relevant to medicine. When covalently reactive molecules are screened by proteomics to discover new protein engagements, the relevant unit of design is no longer a single compound—it is the complete set of regio- and stereoisomers of a privileged scaffold. Incomplete libraries, constrained by synthetic bias, systematically miss the very interactions they set out to find.

Radical cross-coupling removes that constraint. By pairing stereorandomizing and stereopreserving manifolds from simple commercial precursors, we constructed exhaustive piperidine (40) and pyrrolidine (24) matrices and expanded the collection to 108 covalent stereoprobes. Proteome-wide ABPP revealed highly differentiated, stereoselective engagements that further diversified with the choice of covalent reactive group. Selected hits were characterized by X-ray, and protein-directed ABPP expanded the observable ligandability landscape still further.

A collaboration with @VividionRx and the Cravatt lab, appearing today in @ChemRxiv: https://t.co/HE5mPxD4U7

[Baran Lab @BaranLabReads]

Final version out today in @NatureSynthesis : https://t.co/z3vcNFaLz4

[Nima Nasiri @Nima_Nasiri_]

@Jiawei1024 @PSWnano Wow. Congrats Jiawei. Well deserved.

[SimplifyingSynthesis @SimplifyingSyn1]

Total Synthesis of (+)-Roussoellatide (Baran, 2026) https://t.co/7pA9LXIfqO

[Baran Lab @BaranLabReads]

https://t.co/3fKJkwDrTQ

[Luca Massaro @LucaMas_]

Here comes a short review on the current state of electrochemical hydrogenation of arenes and heteroarenes, with a particular focus on how electrochemistry can precisely control partial vs. full reduction of the targeted aromatic rings.

Open access link: https://t.co/sCeMKRGzEH

[Baran Lab @BaranLabReads]

Radical cross-coupling, simplified. No specialized equipment. No exogenous redox. No stoichiometric organometallics. The best part is no part. 

A perspective on the field, appearing today in @ChemRxiv : https://t.co/g65WPyAVSx

[Philipp Neigenfind @pneigenfind98]

Really excited to see this Perspective out today! 🚀

Radical cross-coupling carried a hidden tax: redox. Sulfonyl hydrazides changed that paradigm by bringing their own electrons 🎉

Two years later: what comes next and can radical cross-coupling become as intuitive as a Suzuki?

[Yannick @Yannickbraegger]

Check out the next chapter on nitrogen atom insertion into unactivated alkenes! Here, we present a method that furnishes aza-allenium salts from allylic nucleophiles furnishing N-heterocycles (3-imidazolines & 3-oxazolines) which were previously not generally accessible.

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[Nima Nasiri @Nima_Nasiri_]

@Jiawei1024 @BaranLabReads Thanks Jiawei, it’s very kind of you 🙏

[Nima Nasiri @Nima_Nasiri_]

One C–C bond became our Battle of Thermopylae. Pass closed.

6 mo in, @BaranLabReads hydrazide RCC arrived.

Right reaction, right lab, very right timing. 😅

Desymmetrization + ring contraction → (+)-roussoellatide, 11 steps.

SI = casualty report 👀

🔗 https://t.co/h6ytXeCxB2

[Nima Nasiri @Nima_Nasiri_]

@Eugene_T0th Bro 😂 that means a lot coming from you — pretty sure the ‘legend of a chemist’ title belongs on your side though. Appreciate you man!! ❤️

[Nima Nasiri @Nima_Nasiri_]

@Eugene_T0th @BaranLabReads Thanks so much Eugene!! Means a lot coming from a chemist like you — always excited to see what you’re working on too! 🙏

[Total Synthesis @TotalSynthesis]

11-Step #Synthesis of (+)-Roussoellatide by @Nima_Nasiri_ and @BaranLabReads at @scrippsresearch in @ChemRxiv https://t.co/Yhd97LqdFZ

[Baran Lab @BaranLabReads]

RCC to the RESCUE: A rapid, convergent synthesis of roussoellatide enabled by redox-neutral radical cross-coupling, completed by @Nima_Nasiri_. A case study in how RCC prevails when classical polar methods fail. Out now in @ChemRxiv : https://t.co/gDlDQHQ4AU

[Nima Nasiri @Nima_Nasiri_]

@nettik_etuc @46xyt مادرید بیلو خرید چون‌ به نظرشون وینگر چپ تیم به اندازه کافی خوب نبود (دیماریا). سالیم که بیل اومد، زمانایی که رونالدو و بیل آماده بودن، دیماریا اصلا بهش بازی نمیرسید و رو نیمکت بود. ولی از خوش شانسیش، اون‌ سال رونالدو و بیل نوبتی مصدوم میشدن.

[Nima Nasiri @Nima_Nasiri_]

@peymanpp @Minaei_izad @reyhaneh_dh ببخشید من اخبارو خوب دنبال نمیکنم. کجا بمب گذاری کرده؟ ممکن لینک خبرشو برام بفرستین؟

[Nima Nasiri @Nima_Nasiri_]

@dkhtrtrk4 تو ۲ روز چندین هزار نفرو سلاخی کنیم برای حفظ حکومت

[Nima Nasiri @Nima_Nasiri_]

@Gahvare مجاهدین تو لیست کدوم کشور و قاره گروه تروریستی حساب میشه؟ و اینکه ایشون‌ نگفتند عضو گروه مجاهدین هستند، گفتند هوادار این گروهن.