Noha El anwar

Associate Professor Medicine Tanta University, Armed Forces College of medicine , Al Rayan National College ,consultant surgical Pathology and nephropathology

[Yasamin Mirzabeigi, MD @YMirzabeigi]

Our Gynecologic Pathology cases @UMiamiPathology are fascinating! Here’s a striking example of pilomatrix-like high-grade endometrial carcinoma (PiMHEC), a recently described entity mostly driven by CTNNB1 mutations. Look for solid basaloid growth with conspicuous central tumor cell necrosis, and pilomatrix-like keratinization with the hallmark ghost cells. This case also had a focal conventional FIGO grade 1 endometrioid component. IHC shows diffuse nuclear β-catenin with loss of PAX8 and ER in the pilomatrix-like component. These tumors are believed to behave aggressively.

[Noha El anwar @NohaElanwar84]

كلما أنفقت على العلم ، أنفق عليك العلم
كلما سافرت للعلم، سافر بك العلم
كلما يسرت العلم للناس، يسره الله لك

ابدأ من الآن و استثمر في نفسك و أخلص النية

[Guan-Nan Zhang ，张冠楠，MD, PhD @GuannanTiffany]

Clear cell adenocarcinoma it is. 😊

The main differential diagnosis is florid nephrogenic adenoma.
But once you start seeing solid growth, striking atypia, and mitotic activity, it may be time to look beyond nephrogenic adenoma.
See attached two nice cases.
https://t.co/3UK8gLZKyc
https://t.co/bqqDzux6WE
#DxMindMap #BladderPath #GUPath #PathTwitter @JHUpath

[Surgical Pathology Cases @surgpathcases]

Thigh, 40y

#pathology #patologia #bstpath #dermpath

[Noha El anwar @NohaElanwar84]

@shalinirkr21 @MirunaPopescu13 @Janiranavarro @Kenny92954457 @LizMontgomeryMD @Pathologists @RCPath @JClinPath_BMJ @Pathoutlines @MGBpathology @GIJamesMD Lymphoma for IHC Cd20, CD3, Pax 5 , Cyclin D1, CD5, CD 10

[Boonyarit Cheunsuchon, MD @roboonya]

Acute phlebitis in an interlobular vein. Although commonly seen in acute cellular rejection, the lesion itself is not diagnostic for rejection per Banff classification.

[American Journal of Transplantation @amjtransplant]

🔓 Open Access
"The Banff 2024 Kidney Meeting Report: Rejection as a spectrum of phenotypes and focus on differential diagnostic reasoning," Naesens et al.
https://t.co/YJ4ezXiB6V
#Transplantation #KidneyTransplant #Banff #TransplantPathology #DifferentialDiagnosis #OpenAccess

[Ibrahim Mansoor FCAP, FIAC, FACHDM @IbrahimManff]

Not every “cancer” is cancer.

IgG4-related disease can present as a hard mass in the salivary gland, pancreas, orbit, kidney, lung, and many other organs—often mimicking malignancy on imaging and clinically.

Before calling it a tumor: sometimes the immune system is the culprit.

[Janira Navarro @Janiranavarro]

Half of cellular blue nevus are S100 negative but SOX10 positive

Potential pitfall and also a clue when evaluating these lesions

Dr. Folpe #USCAP2026 #pathology #PathX #PathTwitter

[Tugce Cay @drtugcecay]

Gleason grading #pathology #uropath #prostatepath #pathtweet

[Janira Navarro @Janiranavarro]

Before making a diagnosis of invasive breast cancer in a core needle biopsy, be sure it is truly a primary breast tumor, particularly in the era of neoadjuvant chemotherapy

Metastatic serous carcinoma and metastatic melanoma to breast (pic 1)
Metastatic lung adenocarcinoma (pic 2)
Metastatic medullary thyroid carcinoma (pic3)

Of 2423 TNBC submitted to Caris for molecular profiling over 19 months there was a misdiagnosis of TNBC in 73 cases (3%). Half of those cases were non-small lung cancer (data submitted for publication)

Dr. Schnitt #USCAP2026 #pathology #PathX #PathTwitter

[American Journal of Transplantation @amjtransplant]

🔓 Open Access
"XVIIth Banff Conference on Allograft Pathology: The Banff Workshop Heart Report on Microvascular Inflammatory Burden in Heart Transplantation..."by Fedrigo et al
https://t.co/z5HkaRdAL2
#HeartTransplantation #BanffClassification #TransplantPathology

[Arkana Laboratories @arkanalabs]

A sample from the pathology teaching slide set on Lupus Nephritis, jointly prepared by Arkana Laboratories and @goKDIGO. https://t.co/KwXMfV3nTh

#KDIGO #pathology #renal #kidneypath

[Jonathan Zuckerman MD PhD @JZRenalPath]

Sometime the casts have eyelashes. Amyloidogenic variant of light chain cast nephropathy. #renalpath #nephrology #pathtwitter

[Jonathan Zuckerman MD PhD @JZRenalPath]

Interesting finding of large multi-nucleated endothelial cells in a txp biopsy with chronic active AMR. IHC stain is ERG (endothelial cell marker). Probably just a manifestation of chronic endothelial cell injury in this setting #renalpath #pathtwitter #nephrology

[Arkana Laboratories @arkanalabs]

ANSWER: D.
Tubulopathy with isometric vacuolization, acute tubular injury, acute arteriolopathy and TMA can be seen in acute CNIT.

#pathology #nephx #renal #renalpath

[Arkana Laboratories @arkanalabs]

#KidneyQuiz Some of the acute changes associated with calcineurin inhibitor toxicity (CNIT) are:

A) Tubules with isometric vacuolization
B) TMA
C) Only A
D) A and B

#nephX #kidneypath #pathX #nephtwitter

[American Journal of Transplantation @amjtransplant]

🔓 Open Access
"The Banff 2024 Kidney Meeting Report: Rejection as a spectrum of phenotypes and focus on differential diagnostic reasoning," Naesens et al.
https://t.co/YJ4ezXiB6V
#Transplantation #KidneyTransplant #Banff #TransplantPathology #DifferentialDiagnosis #OpenAccess

[Wenyan Zhou @Zhou1217001]

#renalpath young F, NS, normal SCr. The material filling the microaneurysms with double contours was seen in glomeruli. Did not receive any anti-VEGF therapy. Gene test showed MMACHC mutation.

[Boonyarit Cheunsuchon, MD @roboonya]

Multinucleated giant cells in glomeruli of 56 yo man with MPO positive crescentic GN. Usually more frequent in anti-GBM, these cells can also be seen in ANCA GN. Necrotizing arteritis noted in interlobular artery