The relationship between systemic chronic inflammation (SCI w/ its many sources) and diseases throughout our lifespan
https://t.co/EI4ULbaEv8
an outstanding, provocative review/perspective @NatureMedicine @BuckInsitute and collaborators
This great @NatureMedicine review gives an overview of the risk factors and consequences of chronic inflammation throughout life, and calls for robust biomarkers of chronic inflammation that go beyond combining biomarkers of acute inflammation. #suPAR?
https://t.co/hSEYHJghL5
Although acute inflammation is necessary under physiological conditions, systemic chronic inflammation not. This perspective in @NatureMedicine explores causes & consequences of low-grade chronic inflammation and suggest some actions for keeping it at bay https://t.co/jLJA8njAeY
Women with poor exercise capacity were 4x more likely to die of heart disease, 2x more likely to die from cancer, and had a 4x higher all-cause mortality rate compared to women with good exercise capacity (determined by a treadmill test at baseline). https://t.co/mc0LQ3vBcz
OSTEOPOROSIS como CONSECUENCIA de la INFLAMACIÓN CRÓNICA: TNF-𝛂 ⇨ ⇪secreción de RANKL (Ligando del RANK - receptor de activación del factor nuclear kB) por células del estroma, osteoblastos y leucocitos activados ⇨ RANKL se liga a RANK en osteoclastos (y en sus precursores).
El NF-kB (factor nuclear potenciador de las cadenas ligeras kappa de los linfocitos B) es un importante regulador de la INFLAMACIÓN y su crónica activación tiene varias consecuencias adversas. Afortunadamente, varios compuestos bioactivos de los alimentos frenan al NF-kB.
New paper on #microbiome of the built environment concludes "Our results highlight that the loss of microbial diversity correlates with an increase in resistance...it is time to reconsider our behavior in the built environment"
https://t.co/cax1A5oPJQ
Mucho se habla de SIBO (sobrecrecimiento bacteriano del intestino delgado) por sus varias consecuencias adversas. Una de sus principales causas es el uso crónico de inhibidores de la bomba de protones (p.e. omeprazol).
Randomized crossover trial of ultraprocessed vs. unprocessed diet from @KevinH_PhD group is very interesting. Calorie intake +508 kcal/d on ultraprocessed diet even though kcal density, macros, sugar, and fiber were matched!
https://t.co/a2nBxrEdO6