rob oslund

[Becca J. Carlson @beccajcarlson]

AI has transformed how we design therapeutics.
But targeted delivery is still an expensive guessing game.
Today @BobbyHollings and I are launching @deliverome with @beckypferdehirt and @radialscience at @AsteraInstitute, to fix that. 🧵

[Bobby Hollingsworth @BobbyHollings]

@AashishManglik @OslundRob @AnthropicAI @EvosepBio @biognosys We're hiring (levels flexible)
Proteomics, Functional Genomics, Cell biology, Research Associate; https://t.co/YoVkqHtw5U
Not sure if these are quite the right fit? [email protected]

[rob oslund @OslundRob]

What if tumor targeting selectivity was driven not just by expression, but by proximity?

We introduce TAPAs—Tumor-Associated Proximity Antigens—spatially co-enriched with TAAs.

Learn more on TAPAs + our lead program IDP-001 at #AACR2025

Posters: 2933, 4244, 4255, 5445, 6073

[rob oslund @OslundRob]

Targeting two proteins on the same cell surface via bispecific antibodies is enabling exciting opportunities for novel modes of therapeutic action in the clinic. In this review we highlight their growing impact from early discovery to late clinical stage.

https://t.co/SSYxxsTTIu

[rob oslund @OslundRob]

Super excited to share this announcement on the launch of InduPro! “We leverage inherent and induced proximity to modulate disease biology towards next-generation therapeutics”

https://t.co/DPzaHkQ1UC

[Ryan Cross the Science Boss @RLCscienceboss]

Former Merck scientists have raised $85M to map and drug protein interactions in cancer and autoimmune disease. One goal is to find new pairs of proteins that can be hit simultaneously for more targeted drugs. Read more in my exclusive for @endpts

https://t.co/RW0D4w1KPb

[rob oslund @OslundRob]

Our final version of our manuscript now out in @ACSCatalysis! Here we leveraged tissue-penetrating, deep red light-mediated photoredox catalysis for peptide stapling and protein labeling in patient-derived tissue systems.

https://t.co/AjH94VfvqG

[STEM Hub for Industry Navigation and Exchange @MentoringShine]

S.H.I.N.E. isn't just about mentorship – it's about connections. Join a network of STEM enthusiasts, mentors, and pros who share your passion and drive. #STEMConnections #ProfessionalNetwork #WomenInTech #TechInnovation
#EngineerLife #WomenInSTEM
#MinoritiesInSTEM

[Suprama Datta @SupramaDatta]

Our pre-print is officially out! Kudos to @FadNiyi @OslundRob @DaYuanChen1 @drmohsan. It was an amazing journey and look forward to more!

https://t.co/tP1FkLuJz4

Thank you @CellChemBiol for publishing our work and @yizheng_art for the illustrations!

[Mathieu Frenette @Mat_Frenette]

Congratulations to @TaylorOHope on her final PhD project being accepted in @ChemicalScience !

Thank you to @OslundRob @FadNiyi for getting us interested in photochemical protein tagging !

https://t.co/y45UD7m1eG

[Baran Lab @BaranLabReads]

The final version of this publication has appeared in @NatureChemistry : https://t.co/PpWnT1tOfw

[Martins S. Oderinde, Ph.D @oderinde_m]

Check out our latest article in @ACSCatalysis!
We have developed a general, dual-catalytic method that promotes the decarboxylative cross-coupling of previously unexplored α-amino acids with aryl bromides. #ACSCatalysis #BMSChemistry
https://t.co/PUP6wn9WuN

[rob oslund @OslundRob]

Pre-print is now officially out.

https://t.co/7zYB4WCvn0

Thank you @OrgBiomolChem for publishing this work and to the many folks involved for getting this to the finish line!

https://t.co/QK3WWCEX2i

[rob oslund @OslundRob]

Protein communities that assemble between physically interacting cells play important signaling roles. In this preprint, we report a Flavin-dependent proteomic-platform to identify these synaptic protein environments.

https://t.co/nH0rDiIjh4

[rob oslund @OslundRob]

Our pre-print describing a near-infrared light-based photocatalytic labeling technology with applications in peptide stapling and profiling of normal and patient-derived tumor tissue.

https://t.co/VpDqJisk7p

[Nicholas Tay @malayoman]

Happy to share that this preprint from @RovisGroup has found a home at @NatureChemistry

https://t.co/wdlAiCCnHP

A start of much more to come in this exciting area!

[rob oslund @OslundRob]

Excited to see our pre-print officially out.

Thank you
@NatureChemistry
for publishing this work!

Shout-out to
@yizheng_art
for the artwork including this awesome TOC graphic!

https://t.co/1RDUBp0v0l

[rob oslund @OslundRob]

Great collaborative effort with the ⁦@RovisGroup⁩ and ⁦@malayoman⁩ on a novel red light photocatalyst-mediated technology for targeted profiling of tumor antigens. https://t.co/1TDFIvAObs

[Rovis Group @RovisGroup]

It’s been a long time coming! Our red-light photoproximity labeling method is on @NatureChemistry! We can form triplet nitrenes using low energy light, enabling its use in targeted labeling of local protein environments on live cells.
https://t.co/0OTYEQVCF0

[Rovis Group @RovisGroup]

@NatureChemistry Great job, @malayoman, @FadNiyi, @OslundRob, our other collaborators (Nari Ryu, Aleksandra Olow) and to the Reichman group!

[rob oslund @OslundRob]

We often compare this to the goldilocks principle where the reactive intermediate half-life and rate of generation combine to play keys roles in profiling protein neighborhoods.

[rob oslund @OslundRob]

Protein communities that assemble between physically interacting cells play important signaling roles. In this preprint, we report a Flavin-dependent proteomic-platform to identify these synaptic protein environments.

https://t.co/nH0rDiIjh4

[rob oslund @OslundRob]

On the other end, using a peroxidase-based method we observed promiscuous labeling on both interacting cells leading to enrichment of 100s of proteins. While RFT and HRP both rely on phenoxy radicals, rate of generation is likely responsible for the different labeling patterns.