Ray

I'm passionate about (big breath) Sheffield Wednesday FC, football, cycling, swimming, history, software and internet technology

[Ray @OwlsAndBytes]

https://t.co/sD7i6QSlZQ
Shameless plug for Amy's podcast

[Dr Clare Craig @ClareCraigPath]

Not a single extra signature this morning so I am time stamping this.

12:20

[Ray @OwlsAndBytes]

@raimeyuu I've shared it with the team also :)

[Mark Seemann @ploeh]

New article: Why use ORMs if LLMs write code? https://t.co/X3WwkVvv03

[Damian Płaza @raimeyuu]

New tale: https://t.co/naTTIY7iQU in which we follow one engineer and the three lenses she grows

* is talking about "hearts" in IT just BS for romantics?
* was "typing was never the bottleneck" true - and still not the point?
#dotnet #dddesign #softwarearchitecture #csharp #java

[Ray @OwlsAndBytes]

@fizzipop25

[🏴󠁧󠁢󠁥󠁮󠁧󠁿InsideLucysHead🏴󠁧󠁢󠁥󠁮󠁧󠁿© @InsideLucysHead]

An attorney was working late one night in his office when, suddenly, Satan appeared before him...

The Devil made him an offer. “I will make it so you win every case that you try for the rest of your life.

Your clients will worship you, your colleagues will be in awe, and you will make enormous amounts of money.

But, in return, you must give me your soul, your wife’s soul, the souls of your children, your parents, grandparents, and those of all your friends.”

The lawyer thought about it for a moment, then asked, “But what’s the catch?”

[Ray @OwlsAndBytes]

@ped

[P.D. Mangan Health & Freedom Maximalist 🇺🇸 @Mangan150]

Low carb diet in obese diabetics

Calories were unlimited, but spontaneously declined by 1000 calories/day. 3.6 lbs. lost in 14 days.

24-hour plasma glucose normalized. Insulin sensitivity +75%. Triglycerides -35%.

Seems a lot more effective than drugs or calorie counting.

[Dr Clare Craig @ClareCraigPath]

This is a good explanation of what folic acid does in the developing brain.

It is a drug.

It alters what the cells do.

It has never gone through safety testing as a drug.

Sign the petition.

[Guillaume Meyer @guillaumemeyer]

🧹watermarks-remover now supports watermarks from OpenAI and Gemini in addition to Claude.
https://t.co/OxSdnAjEGe

[Dr Clare Craig @ClareCraigPath]

🚨WARNING🚨

If you are in two of the categories below you need to restrict your folic acid intake to about 80g of flour a day.

Over the age of 50 - that is 38% of population or 26 MILLION people.

Gov decided no more pizza for you!

There was no debate!

Sign the petition:

[Military History Now @MilHistNow]

Today in 1920, Poland's beleaguered army makes a last stand against the invading Red Army at the gates of Warsaw. Their astounding victory, which ends the Soviet conquest of Europe, will become known as the Miracle on the Vistula.

Few outside of Poland even know the story. See: https://t.co/qDakCqpxX1

[Ray @OwlsAndBytes]

@fizzipop25

[TheManWhoFellToEarth @ReturnofColin2]

This time tomorrow 🌞🌗🌚

[Ray @OwlsAndBytes]

@fizzipop25 😂

[🍀Louie Kerr 🇮🇪💚 @LouieKerr8]

🤣

[Ray @OwlsAndBytes]

@fizzipop25

[PUNS @ThePunnyWorld]

Someone told me you could watch a solar eclipse through a colander...

I tried it and ended up straining my eyes.

[Ray @OwlsAndBytes]

@fizzipop25

[Ziv @biohackerziv]

90% of your Mold, MCAS, Histamine random food allergies can be systematically resolved without restrictive diets or endless immunosuppressants.

Mainstream medicine treats MCAS as a random autoimmune error. In reality, mast cell hyper-reactivity is a cellular energy failure. When mycotoxins, endotoxins, and stress suppress thyroid output and drain micronutrients, mast cells lose cellular voltage and spontaneously degranulate, flooding your body with histamine, serotonin, and inflammatory cytokines.

By reorganizing these interventions by biological priority—starting with circadian alignment and gut/metabolic mechanics down to targeted enzymatic cofactors—you can stabilize your immune system and clear histamine efficiently 👇

1. Circadian Alignment: Morning Sunlight & Blocking Night Blue Light

Priority: Foundational.

The Science: The PER2 and BMAL1 circadian clock genes directly regulate the molecular clock inside mast cells. Circadian disruption causes spontaneous mast cell degranulation regardless of diet.

Morning sunlight triggers pituitary peptide release and establishes normal daytime cortisol, while blocking blue light 3–4 hours before bed drives pineal and mitochondrial melatonin synthesis—the master antioxidant required to repair mycotoxin-induced mitochondrial damage.

2. Morning Bioenergetic Fuel: Warm Coffee + Milk + Sugar (~30 Mins Post-Waking)

Priority: Metabolic & Motility Driver.

The Science: Waiting 30 minutes allows your natural Cortisol Awakening Response (CAR) to peak normally before buffering it. Coffee triggers Cholecystokinin (CCK) release to dump conjugated bile acids—natural detergents that sterilize the small intestine and kill histamine-producing SIBO.

Adding sucrose fuels liver glycogen to convert inactive T4 into active T3, while whole milk calcium binds bacterial endotoxin (LPS) in the gut. Active T3 keeps the Migrating Motor Complex (MMC) sweeping, preventing food from fermenting into histamine.

3. Nocturnal Adrenal Shield: 15–30g Raw Honey Before Bed

Priority: Cortisol & Sleep Stabilization.

The Science: As liver glycogen depletes overnight (around 2:00–4:00 AM), the adrenals release a wave of cortisol and adrenaline to maintain blood glucose. Stress hormones directly trigger mast cell degranulation and spike prolactin, causing middle-of-the-night waking and morning histamine flares. Pre-bed raw honey saturates liver glycogen, keeping nocturnal cortisol low, sleep deep, and overnight T3 production active.

4. Dietary Foundation: Warm, Fast-Digesting Foods

Priority: Substrate Reduction for Pathogens.

The Science: Cold, raw, or complex slow-digesting starches delay gastric emptying and linger in the small intestine. Opportunistic bacteria ferment these foods, decarboxylating the amino acid histidine into free histamine while shedding LPS endotoxin. Eating warm, easily assimilated foods requires minimal digestive energy, leaving zero fermentable substrate for bacterial histamine generation.

5. Luminal Endotoxin & Estrogen Binding: Ray Peat Raw Carrot Salad

Priority: Gut Barrier & Hormonal Shield.

The Science: Estrogen directly stimulates mast cells to degranulate, while free histamine stimulates the ovaries and adrenals to produce more estrogen (a toxic feed-forward loop). The unique insoluble fibers of a raw carrot (shredded daily with raw coconut oil, apple cider vinegar, and salt) act as a non-digestible adsorbent matrix that binds un-cleared estrogen and bacterial LPS in the bowel, carrying them out through the stool before they can reach the liver or trigger histamine release.

6. Dual Receptor Blockade: 0.5mg Cyproheptadine (2x Daily: AM & Dinner)

Priority: Pharmacological Mast Cell & Serotonin Control.

The Science: Cyproheptadine is a potent dual antagonist of histamine H1 receptors and serotonin 5-HT2 receptors. Elevated serotonin acts as a direct vasoconstrictor and mast cell secretagogue that increases microvascular permeability. Blocking 5-HT2 and H1 simultaneously stabilizes mast cell membranes, quenches CNS hyper-arousal, lowers stress hormones, and stops histamine-driven tissue swelling.

7. Bioavailable Mast Cell Stabilization: Quercetin Phytosome (250mg 2x Daily: AM & Dinner)

The Priority: Direct Flavonoid Inhibition.

The Science: Quercetin downregulates NF-kB and inhibits the phosphorylation of Protein Kinase C (PKC), which blocks the intracellular calcium influx required for mast cells to release histamine, leukotrienes, and prostaglandins. Utilizing a phytosome formulation overcomes quercetin's naturally poor bioavailability, delivering the compound directly to cell membranes.

8. Enzyme Core Activation: NOW Copper Bisglycinate (6–9mg Total: 3mg with Each Meal)

The Priority: Rescuing Diamine Oxidase (DAO).

The Science: Diamine Oxidase (DAO) is the primary enzyme responsible for breaking down extracellular histamine in the gut lumen and blood. Copper is the obligate structural catalytic cofactor at the active center of the DAO enzyme. Mycotoxins and chronic stress deplete systemic copper stores, shutting DAO down completely. Supplying 3mg of bioavailable copper bisglycinate per meal directly re-saturates the active centers of DAO so it can digest dietary histamine.

Overtime copper can lower zinc, good ratio of zinc to copper is 15:1

9. Whole-Complex Radical Scavenging: Vitamin C from Acerola Cherry

Priority: Enzymatic Cofactor & ROS Quenching.

The Science: Ascorbic acid acts as an electron donor that directly quenches mycotoxin-induced Reactive Oxygen Species (ROS) and stimulates DAO activity. Using whole-food Acerola Cherry provides the complete Vitamin C complex (including tyrosinase) without the ultra-high doses of isolated synthetic ascorbic acid that can strip bioavailable copper out of circulation.

10. Dual Breakdown Pathways: Life Extension B-Complex (B100)

Priority: Methylation & Decarboxylase Cofactors.

The Science: Histamine is cleared via two main pathways: DAO (which requires active Vitamin B6 as P5P) and Histamine N-Methyltransferase (HNMT, which degrades intracellular brain/tissue histamine). HNMT depends on SAMe-mediated methylation. A high-potency B100 complex supplies active P5P, B12, and Folate to keep both the DAO and HNMT pathways operating at full capacity.

11. Membrane Potential Maintenance: 100mg Magnesium Bisglycinate (With Each Meal)

Priority: Cellular Voltage & Calcium Buffering.

The Science: The cell-surface Ca2+-ATPase and Na+/K+-ATPase pumps require magnesium-bound ATP to function. When magnesium is depleted, cytosolic calcium rises, causing smooth muscle spasms and triggering spontaneous mast cell degranulation. 100mg of magnesium bisglycinate with each meal buffers intracellular calcium and maintains stable cell membrane voltage.

12. Enzymatic Network Balance: Seeking Health Trace Minerals II

Priority: Broad-Spectrum Cofactor Saturation.

The Science: Provides essential micro-minerals (Selenium, Zinc, Boron, Molybdenum). Selenium is required for Glutathione Peroxidase (GPx) to quench lipid peroxides and for deiodinase enzymes to convert T4 to active T3. Molybdenum fuels Sulfite Oxidase to clear sulfur compounds that often trigger pseudo-allergies in mold-exposed individuals.

13. Anti-Estrogenic Fat-Soluble Support: IdeaLabsDC Estroban (A, D, K, E)

Priority: Nuclear Receptor & Membrane Protection.

The Science: Vitamins A (Retinol) and D3 promote immune self-tolerance and stabilize regulatory T-cells. Vitamin E directly antagonizes estrogen at the receptor level and prevents lipid peroxidation of mast cell membranes, while Vitamin K2 (MK-4) prevents microvascular calcification and tissue inflammation.

14. Intracellular Detoxification: GlyNAC (Glycine + N-Acetyl Cysteine)

Priority: Mitochondrial Glutathione Synthesis.

The Science: Combines glycine and NAC to drive the rate-limiting synthesis of intracellular Glutathione (GSH) inside mitochondria, clearing accumulated mycotoxins. Additionally, glycine acts as an inhibitory neurotransmitter that binds directly to glycine receptors on mast cells, hyperpolarizing their membranes and raising the threshold required for them to degranulate.

Summary of Execution

Morning: Get sunlight, wait 30 minutes, drink warm coffee with milk and sugar, take Quercetin Phytosome (250mg), 0.5mg Cyproheptadine, and your AM supplements.

Meals: Take 100mg Magnesium Bisglycinate + 3mg Copper Bisglycinate with each warm meal.

Afternoon: Eat the Ray Peat Raw Carrot Salad to clear intestinal endotoxin and estrogen.

Dinner: Take your second dose of Quercetin Phytosome (250mg) and 0.5mg Cyproheptadine with dinner.

Pre-Bed: Block blue light 3–4 hours before sleep and take 15–30g of raw honey to lock in overnight liver glycogen and keep stress hormones suppressed.

[Peter Morris @MrPeterLMorris]

Developer Tip: If you want to use GIT WorkTrees then do your Windows development on a Dev Drive (or Linux ReFS).

It employs Copy On Write. So copied files are just pointers to the original files until either the source or the copy is changed.

I have 1.16 TB free on my Dev Drive. I copied 658 GB of photos and still had 1.16 TB of free space afterwards.

No need to fill up your drive, or kill your Solid State Drive's lifespan with too many writes. Use a Dev Drive!!!
https://t.co/6b7FTNOA19

[Typemock @typemock]

Every pull request gets a code review.

Why don't our tests get the same attention?

https://t.co/1Wb1ygmzVF

[Ray @OwlsAndBytes]

@fizzipop25

[Ancient History Hub @AncientHistorry]

In 2012 a woman named Philippa Langley talked archaeologists into digging up a council parking lot in Leicester because she was convinced the lost grave of King Richard III was under it. Nobody had known where his body was for over 500 years. She later said that when she stood on one particular spot, she felt a strange certainty he was right there. That spot was a parking space painted with the letter R for reserved.

They started digging. On the very first day, in the first trench, they hit human bones right under the R.

It was him. The spine curved hard to one side from scoliosis, which meant the Tudor stories about a twisted king were not pure propaganda after all, though the drooling monster Shakespeare wrote was. The skull told the rest. He had been hacked at least ten times. Part of the back of his head was sliced clean off by a blade, the wound that likely killed him. There were smaller cuts inflicted after death, humiliation wounds, the kind you give a body you hate. He had been dumped in a grave dug too small for him, hands possibly still bound, no coffin, no shroud, head shoved up against the side.

To prove it was really him, scientists traced his DNA down 500 years through the female line and found two living matches. One of them, Michael Ibsen, was a cabinetmaker. He ended up building the coffin his own distant royal ancestor was finally buried in.

Richard III died at the Battle of Bosworth in 1485, the last English king ever to fall in combat, the last of the Plantagenets. In 2015 they reburied him in Leicester Cathedral with full honors. Benedict Cumberbatch, who turns out to be a distant cousin, read a poem at the service.

Five centuries under a parking lot, found on day one, under a letter R.

[Work Chronicles @_workchronicles]

(comic) Retention strategy