The PALOH Trial

The Pharmacogenetics To Avoid Loss of Hearing Trial | Supported by @NIHRresearch @RNID and @ManchesterBRC | Reporting March 2022

[The PALOH Trial @PALOH_Study]

Thrilled that the @PALOH_Study has been published today in @JAMAPediatrics.

https://t.co/hcp5NdcCgV

Over the next week we'll highlight the main findings, the potential benefits for patients, and what this means for rapid genetic testing in healthcare. More to come next week.

[The PALOH Trial @PALOH_Study]

Big news!
PALOH-UK is introducing the PALOH study to neonatal units across the UK and we are recruiting for our Parent Advisory Group now!
Please see posters below for more details

[genedrive plc @genedriveplc]

Huge congratulations to @GeneticBill, @John_H_McD and the PALOH team at @MFTnhs who won Research Project of the Year: STEM at @timeshighered Awards last night!

[UoM Biology, Medicine and Health @FBMH_UoM]

Congratulations to the PALOH team! Winner of Research Project of the Year: STEM at the @timeshighered awards 2024 🏆

👏 @GeneticBill, @John_H_McD and all involved @OfficialUoM and @MFTnhs. @NIHRresearch @ManchesterBRC @MFT_Research

[NIHR Biomedical Research Centre: Manchester @ManchesterBRC]

Another incredible achievement for the PALOH team!

Winner of Research Project of the Year: STEM at last night’s @timeshighered awards 2024 🏆

Huge congratulations to all 👏

[MFT Research and Innovation @MFT_Research]

Congratulations to the PALOH study team who won Research Project of the Year: STEM at the @timeshighered Awards 2024🏆👏.

The team developed the world’s first bedside genetic test that can prevent critically ill newborn babies from going deaf if treated with a common antibiotic.

[The PALOH Trial @PALOH_Study]

Very proud to announce that tonight @PALOH_Study won the @timeshighered STEM award for @OfficialUoM #THEAwards

[Times Higher Education @timeshighered]

@UEL_News @dundeeuni @imperialcollege @LSTMnews @moh_liberia @UniOfLib @effecthope @QMUniversity @LSBU @UniofNottingham Winning #THEAwards Research Project of the Year: STEM is @OfficialUoM for creating the world’s first rapid bedside test to detect a gene for antibiotic-induced deafness in newborns, which the judges described as “a game changer for thousands of babies”👶

[genedrive plc @genedriveplc]

🎆Congratulations to @GeneticBill @John_H_McD and the team at @OfficialUoM @MFTnhs on their nomination for STEM Research Project of the Year!

Winners will be announced on 28th November, we wish you all the best of luck!

https://t.co/pQt8b43eAu

#GDR

[MFT Research and Innovation @MFT_Research]

With £1.4m funding from @NIHRresearch and the @UK_Life_Science, PALOH-UK will demonstrate at a larger scale, how the test can be used in a timely way to ensure babies get a safe, effective antibiotic without affecting normal clinical practice.

👇
https://t.co/vnmFXWjixJ

[MFT Research and Innovation @MFT_Research]

🗞️ A pioneering genetic test developed by @MFTnhs researchers, that could prevent critically ill newborn babies going deaf if treated with a commonly used antibiotic, is being trialled across 14 NHS specialist newborn units, in the new PALOH-UK study.

👇
https://t.co/vnmFXWjixJ

[The PALOH Trial @PALOH_Study]

@genedriveplc @GeneticBill @John_H_McD @OfficialUoM @MFTnhs Thank you!

[John McDermott @John_H_McD]

The afternoon session at #ESPT23 is underway with @GeneticBill speaking about the use of point of care systems in pharmacogenetics - discussing our experience of the @PALOH_Study with @genedriveplc.

[Bill Newman @GeneticBill]

@BSACandJAC #grammegative2023
Waiting to present on @PALOH_Study and use of point of care testing to avoid hearing loss in neonates

[BAPM @BAPM_Official]

We're pleased to announce our shortlisted nominees for this year's BAPM Gopi Menon Awards.

The winners will be announced on Tuesday 12 September at the BAPM Annual Conference.

You can find the full shortlist here>
https://t.co/U1txeM54l9

[Kamla Pillay @KamlaPillay]

Great talk about rapid point of care testing to detect a genetic variant associated with aminoglycoside related ototoxicity. Potential for a huge impact in management of neonates with sepsis @PALOH_Study #rcpch2023

[RP @Investor_pilot]

World's 1st rapid test to identify a particular gene in babies +prevent antibiotic induced hearing loss -
now recommend by @NICEComms for use in @NHSuk

CE certified with potential US #FDA approval in the near future.

#gdr @genedriveplc @PALOH_Study @MFTnhs #neonatal #AIHL

[North Thames Genomic Medicine Service @NorthThamesGMS]

Patients with the m.1555A>G genetic variant are at increased risk of deafness when treated with antibiotics called aminoglycosides.

Join our webinar to learn about the pharmacogenomic test for this variant:
📅 13 April 12-1pm
📅 10 May 1-2pm

Visit https://t.co/UPCqIlQaOL

[This Week in Hearing @WeekinHearing]

Preventing Hearing loss Through Genetic Screening: Exploring Genedrive's Game Changing Technology. @genedriveplc #geneticscreening #hearinghealth #hearingloss #hearingcare https://t.co/8Tlpd7RMtm

[Centre for Personalised Medicine, Oxford (+ bsky) @CPMOxford]

Kate uses the brilliant @PALOH_study to illustrate the issues, and you can read more about this in her fascinating article in @JME_BMJ:
https://t.co/RGE7sUwqE2

[Centre for Personalised Medicine, Oxford (+ bsky) @CPMOxford]

As a society, we tend to focus a lot on risk and try to control it through regulation - but how well does that work in #genomic medicine?
@kvlyle talks to us about this in the 7th episode of the CPM podcast:
https://t.co/MpgG8irZX9

[Bill Newman @GeneticBill]

@John_H_McD @VidehaSharma @pmw777 building on @nwgmsa @PALOH_Study #PGx with many colleagues across @OfficialUoM @MFT_Research @HealthInnovMcr @DEVOTEProgramme