PL Loyher

Research scientist, Immunology

[allen institute @AllenInstitute]

Microglia feet are highly dynamic and can be in contact with dense networks of axons.

In this video by our #ElectronMicroscopy team using MICrONS data, a microglia (purple) contacts with an excitatory pyramidal neuron (gold). Slowly the axons under the feet are revealed.

[Manhattan Bird Alert @BirdCentralPark]

Three chicks in the Red-tailed Hawk nest on Central Park South near Seventh Avenue.

[ᒍOᕼᗩᑎ ᗪᑌᑕᕼEᑎE @DucheneJohan]

TREM2+ macrophages have rapidly emerged as key regulators in diseases.

Studying them requires specific antibodies.

Among 14 tested antibodies in KO cell lines, 5 are specific in WB.

Pick up the right one.

Full report: https://t.co/ypWzdLziaP
Or here: https://t.co/VYEheOoOKP

[HonestReporting @HonestReporting]

Journalism demands fact checking, disclosure, and due diligence. What @NickKristof and his editors gave @nytimes readers was an uncritical amplification of unverified claims, outlandish accusations, and untrustworthy sources.
The question is no longer just whether al Sai's story is credible.
It’s how the @nytimes published a piece of this magnitude, based on a source with this background, without disclosing any of it to readers.
That is the story.

[PL Loyher @PLoyher]

@EYakoby The protest are smaller but gettting much scarier. I just came acros them after work, they violently took over the kid's park in front of me. NYPD now has a huge presence surrounding and following them.

[Science Advances @ScienceAdvances]

Moonlight—or the lack thereof—affects the energy and foraging of nocturnal organisms like the red-necked nightjar, a monthly cycle that shapes the timing of key life events like migration and reproduction. https://t.co/Lxocnvz1bb @ebdonana @HedenstrmAnders

[Elisabeth Bik @MicrobiomDigest]

While the non-disclosure of the conflicts of interest is a serious issue, it is also important to point out that @addictedtoigno1 and others found several instances of image duplication in this paper.
https://t.co/jYKTF2aUWr

[PL Loyher @PLoyher]

@AlvaroCurielGa1 The retraction is a massive red flag. If you can’t be transparent about your financial stakes in a biotech company (Vega oncotarget) you shouldn’t be trusted to lead a clinical trial. That 4 millions raised from the public could have funded dozens of other brillant scientists.

[PL Loyher @PLoyher]

@AlvaroCurielGa1 The retraction is a massive red flag. If you can’t be transparent about your financial stakes in a biotech company (Vega oncotarget) you shouldn’t be trusted to lead a clinical trial. That 4 millions raised from the public could have funded dozens of other brillant scientists.

[PL Loyher @PLoyher]

@pnatarajanmd @ChrisAWalsh1 Very interesting data! Surprising they didn’t cite the recent Vicario et al paper in @Neuroncellpress 2025. The conceptual and functional overlap is deep , they feel like two sides of the same coin in proving how somatic variants drive inflammatory microglia states.

[PL Loyher @PLoyher]

Huang et al report on somatic mutations in AD microglia using a massive cohort which allowed identification of new variants 👀. It builds on the foundation laid by Vicario et al. in both eLife and Neuron ('24), who first identified the enrichment of these microglial clones.

[Cell @CellCellPress]

Now online! Somatic cancer variants enriched in Alzheimer’s disease microglia-like cells drive inflammatory and proliferative states https://t.co/1HjVGDcD9n

[PL Loyher @PLoyher]

@franceinfo «L'autorité a également rappelé que l'UNRWA aurait été blanchie dès janvier 2024 des accusations de collusion généralisée avec le Hamas”. Sachant qu'elle n'a pas du tout été blanchie et que c’est du 100 % Hamas, du coup, c’est "l’autorité" ou l’Arcom qui ment ? Quel monde de fous

[Jacqueline Emery @jacquelineUWS]

I like this raccoon’s vibe. 🦝

#urbanwildlife #centralpark

[PL Loyher @PLoyher]

@DidierMaisto Au début de la guerre, les estimations du nombre de combatants du hamas et jihad islamique étaient d’environ 60000 à Gaza. Le compte est bon.

[PL Loyher @PLoyher]

@le_Parisien Volontairement relocalisés @le_Parisien. C’est fatiguant votre manipulation.

[PL Loyher @PLoyher]

@grok @Copernicus2013 @CliffordDMay “Still the top single source” thanks grok, . Also ask it how many satellites france has, lol.

[PL Loyher @PLoyher]

@Copernicus2013 @CliffordDMay And I know he did that. Still the US remains one of the most critical actor helping Ukraine. If trump really wanted to stop everything he could have, he did not. That is why Ukrainian president recently proposed to help the US in the Iran war.

[PL Loyher @PLoyher]

@Copernicus2013 @Nasho_Tak_Zhit @CliffordDMay That europe took over the intelligence . You are not a supporter of Ukraine if all you care is being a troll. If you care about a war where people are fucking dying you should care about whats happening in real time not just politco articles.

[PL Loyher @PLoyher]

@Copernicus2013 @CliffordDMay To be what? I shared with you public information about intelligence still provided by the Us and that the Europe take over is BS. Thats is verifiable in 10 seconds. You dont want to check this information? Sending unrelated article will not do anything.

[PL Loyher @PLoyher]

@Nasho_Tak_Zhit @Copernicus2013 @CliffordDMay Im not American or pro trump you piece of shit. Im trying to correct all the lies you guys are spreading. You dont care about the truth during an ongoing war that does not make you a supporter of Ukraine.