Conor Grant

ID SpR @stjamesdublin, @tcddublin PhD student of TB immunology, Wellcome/HRB @ICATProgramme fellow, wannabe rock climber

[Conor Grant @PaleBlueDoc]

Couldn't have done this without my amazing co-authors: Emily Duffin, Dr Finbarr O'Connell, Dr Parthiban Nadarajan, Prof Colm Bergin, Prof Joseph Keane, and Dr Mary O'Sullivan. @TBImmunologyTCD @stjamesdublin @ICATProgramme @tcddublin @TCDTMI

[Conor Grant @PaleBlueDoc]

Delighted to have my paper published in Immunology.

We investigated if/how macrophages from human lungs respond to SARS-CoV-2 spike and envelope proteins, and whether these responses were affected by age or smoking.

@TBImmunologyTCD

https://t.co/bjS7RpsEwC

[Conor Grant @PaleBlueDoc]

But it is exciting because it identifies a mechanism that could partly explain why older adults are at such high risk, and be the basis of further treatment and prevention research.

[Mary Horgan @profmaryhorgan]

Great night ⁦@RCPI_news⁩ celebrating 20 years of Infectious Diseases specialty training 🇮🇪. Our first trainee ⁦@SMHopkins⁩ with current trainees, our future is in good hands ⁦@IDSIreland⁩ ⁦@RCPI_news⁩ ⁦@HIVTox⁩ ⁦@CcoHse⁩ ⁦@colm_bergin⁩

[Mary O'Sullivan @MaryP_OSullivan]

Glad to have been involved too along with @SeonadhO and @TBImmunologyTCD in #TTMI. Great collaborative #tuberculosis research led by Branch Moody in #Harvard. Congratulations to Melissa Bedard et al @jclinicalinvest!
@TCDTMI @tcddublin @stjamesdublin #metabolism #macrophage

[Dearbhla Murphy dervmurphy.bsky @derv_murphy]

I am absolutely delighted to share our paper showing the induction of trained immunity by an adenoviral COVID-19 vaccine published in @jclinicalinvest this evening! A truly massive thank you to @ShareeBasdeo and the whole team for all their help 🥳🥳 https://t.co/MQvp4Dt1PT

[Conor Grant @PaleBlueDoc]

This might explain why previous trials of adjunctive retinol to TB therapy have failed, and suggests that using inhaled exogenous ATRA may unlock vitamin A's efficacy for TB patients

[Conor Grant @PaleBlueDoc]

New review by myself and @AhmadBahlool, @sa_cryan, Joe Keane and Mary O'Sullivan:

All trans retinoic acid as a host-directed immunotherapy for tuberculosis

ATRA holds great promise as a HDT for TB!

@StopTB @TBAlliance @ICATProgramme @tcddublin
#EndTB

https://t.co/YQ9ItKW2ZD

[Conor Grant @PaleBlueDoc]

ATRA is produced from circulating retinol at the site of action, but there are several steps needed before ATRA can have its beneficial effects - including two-step oxidation of retinol to ATRA and then delivery of ATRA to its nuclear receptors by carrier proteins.

[Paddy Mallon @HIVTox]

The red line is what happened to the reported rates of ‘viral-like illness’ - a surrogate for COVID cases - back during the first wave. Look how steeply the curve drops off with widespread buy-in to a lockdown. We did this before and can do it again! #COVID19Ireland

[Conor Grant @PaleBlueDoc]

Hydatid disease not endemic in Ireland?

So they say, but myself and Caroline Conlon would beg to differ (new case report).

🐑🪱🐕🪱🧍‍♂️

What is it about Galway and weird pathology?

https://t.co/6kTWPPQbwA

@HelenTuite1