Pat Lally

Bioinformatics & Computational Biology @biosens8

[Qwen Developers @QwenDevs]

Got you covered bro, 27B is landing this week

[Pat Lally @PatDotPy]

👀

[Synthetic Sciences (YC W26) @SynScience]

Introducing OpenScience. A better, open-source Claude Science.

• Any model: GLM, Kimi, DeepSeek, Claude, GPT, your own fine-tune. Switching is one flag.
• 250+ research skills across ML, comp bio, cheminformatics. All readable, editable, extensible.
• No throttling, no gatekeeping, no one vendor deciding what science is okay.
• Native Atlas integration: many agents, one shared reproducible research graph.
• Runs on your infra. Your data stays yours.

Scientific AI should be open. One company shouldn't own the tools the rest of us discover with, or decide who gets to.

[Pat Lally @PatDotPy]

@anshulkundaje @vijaypande A used RTX 3090 and see how far you can get with the ~30B param class of models :)

[Jake Wintermute 🧬/acc @SynBio1]

"I'm trying to free your mind Neo. But I can only show you the door. You're the one that has to walk through it"

[Pat Lally @PatDotPy]

@dionizije_fa @sudoingX Is the 3.6 score actually run through local hardware? (Eg q4 k m, maybe kv quant)

[Pat Lally @PatDotPy]

@Teknium I wake up
The feature I thought about last night already exists

[Pat Lally @PatDotPy]

decided to move the hallucinations on-prem

[Hannes Stark @HannesStaerk]

Excited to release BoltzGen which brings SOTA folding performance to binder design! The best part of this project has been collaborating with many leading biologists who tested BoltzGen at an unprecedented scale, showing success on many novel targets and pushing its limits! 🧵..

[owl @owl_posting]

Ask not why would you work in biology, but rather: why wouldn't you?

https://t.co/kYEpm5B1IL

openai/gemini gave this essay an A- for evocative imagery. claude gave it a C- for being emotionally manipulative. both are probably right. i feel a little sick re-reading it

[Galagan Lab @GalaganLab]

Last month, @PatDotPy defended his PhD dissertation!

Pat’s work studied E. coli Transcription Factors at multiple resolution scales & provided novel insights into the spectrum of TF binding (more details soon)!

He is now building NGS Analysis Pipeline Services for @BU_PDC!

[Pat Lally @PatDotPy]

@jankosinski Apologies if you’ve answered this already but have you tried this with a “nonspecific” sequence? Might give that a shot later myself but curious what it would find

[Pat Lally @PatDotPy]

When a fly is buzzing around the lab

[Galagan Lab @GalaganLab]

Loving our new OT2 liquid handler! Looking forward to seeing what else it can do! @opentrons #Automation #NGS #HighThroughputBiology

[Wellcome Sanger Institute @sangerinstitute]

Free online #course launched to introduce #bioinformatics and share how we use computational tools to understand disease-causing bacteria #SkillsGap @ACSCevents @FutureLearn https://t.co/5640zFqJBF