PatWilsonLab

[PatWilsonLab @PatWilsonLab1]

Our newest paper is out today in Nature showing how sensitive children’s immune responses are to bias from past immunity.

https://t.co/pyYAtPAVTz

https://t.co/Hjjirx9xve

[PatWilsonLab @PatWilsonLab1]

Congratulations and completely expected to @victora_lab for becoming an HHMI investigator

https://t.co/yZAXja8Qfj

[PatWilsonLab @PatWilsonLab1]

@msdiamondlab Congratulations Mike! @msdiamondlab

[PatWilsonLab @PatWilsonLab1]

@WCMpeds @melodyzeng Seratonin? Really cool @melodyzeng

[Weill Cornell Medicine @WeillCornell]

Gut of newborns has unique bacteria that produce serotonin and promote the development of immune cells that may prevent allergic reactions to food and beneficial gut microbes, according to a preclinical study from @WCMpeds.

https://t.co/3fnTZy14ZD

[PatWilsonLab @PatWilsonLab1]

Great job Josh! This was a "hunch" project that turned out to be so interesting once Josh dug in.
In a nutshell: How do you balance the need for maximum antibody diversity and adaptability with the requirement for maintaining the ability of an antibody to express well?

[PatWilsonLab @PatWilsonLab1]

@camilahcoelho Grants are the means, not the purpose by any measure.

[PatWilsonLab @PatWilsonLab1]

This is an amazing and intuitive approach as @stutangye has done so well for decades

[Stuart Tangye @stutangye]

Absolutely thrilled to lead a team of amazing CIs & AIs who together will aim to improve outcomes for ppl with inborn errors immunity

[PatWilsonLab @PatWilsonLab1]

@sashatarakh Thanks for sharing that video Sasha. It’s so relevant today

[PatWilsonLab @PatWilsonLab1]

@LB_Barreiro @Nature @TaurVil Finally got a chance to read this fascinating story from @LB_Barreiro and colleagues

[Luis B Barreiro @LB_Barreiro]

Most recent work from the lab just out @Nature. By combining ancient DNA work, population genomics, and in vitro infections we show that the Black Death shaped the evolution of immune genes. Kuddos to co-first authors @TaurVil and Jennifer Klunk. https://t.co/y4crzKFMpv

[Barbara Kee @BarbaraLKee]

https://t.co/TaTUrHtv7v

[Mats Ohlin @mats_ohlin]

A curated set of human immunoglobulin germline genes/alleles for better annotation of sequences encoding antibodies and antibody repertoires. It has potential to solve annotation problems you have not been aware of! #antibody #AIRRseq #repertoire
https://t.co/NfiJLfejsB

[Marcos Vieira @Marcos___Vieira]

Antibodies are the product of evolution on two timescales: over millions of years in vertebrate populations, and within weeks of infection or 💉 in populations of B cells. We ask how those timescales interact in our paper out in @PLOSPathogens 🧵 1/n https://t.co/vRdGYYQwsU

[Dr. Jen Gommerman @JenGommerman]

2/ Hi friends - please RT the following 2 ads. We are looking for talented people to join our HI3 team. Help us prepare for future pandemics https://t.co/fJOuYKj7PA

[Dr. Jen Gommerman @JenGommerman]

1/ Hi friends - please RT the following 2 ads. We are looking for talented people to join our HI3 team. Help us prepare for future pandemics! https://t.co/6VZxepM95v

[PatWilsonLab @PatWilsonLab1]

Many thanks to the thoughtful and comprehensive commentary from @ShivPillai4 on our paper led by @SirirukCh about broadly protective mAbs against SARS-CoV-2, both out today in the JCI:
Comment:https://t.co/VlVfhaHjRU

Paper:https://t.co/6vjkn52trk

[PatWilsonLab @PatWilsonLab1]

@florian_krammer Brain surgeon?

[PatWilsonLab @PatWilsonLab1]

What a cool paper. I wonder if there are any active mutator mechanisms involved, analogous to AID in B cells.

[Hao Zhu Lab @Zhu_Lab]

Somatic mutations accumulate in “normal” non-cancerous tissues (blood, skin, liver). But why are mutant clones selected? Do they merely proliferate more, selfishly? Or can clones adapt to disease? Could they protect tissues? We shed light on this: https://t.co/Vu1d4U3stc 1/10

[PatWilsonLab @PatWilsonLab1]

@florian_krammer Oops: Peaceful Easy Feeling should be The Eagles album

[PatWilsonLab @PatWilsonLab1]

@florian_krammer I need a playlist for this because I just can’t decide but going with my current favorite as camping season starts:
Peaceful easy feeling
Hotel California
Desperado