Manav Pathania | @manavpathania.bsky.social

Working on brain tumours like #DMG #DIPG in children and young people, @CR_UK Career Establishment Award recipient

🏳️‍🌈🇮🇳🇭🇰🇲🇾🇸🇬🇺🇲🇬🇧

[Manav Pathania | @manavpathania.bsky.social @Pathania_Lab]

First Pathania Lab paper in @CD_AACR: https://t.co/dIecm8mZMB. We developed 16 mouse models of various subtypes of pediatric high-grade glioma— mirroring their different H3 mutant contexts, anatomical compartmentalizations and co-segregating partner alterations. Thread below 1/17

[Amy Fan @amycfanphd]

Excited to announce our study (w/ @RukmanThota & @MaxKrummel) published today @Nature:
Macrophages “hold our living identities” by taking tiny bites from living cells and presenting this information to CD8 T cells.

https://t.co/9XENtFrB4h

#immunology #cellbiology @immunox @ucsf

[BryanRoth @zenbrainest]

WOW!!
Identification of a neural circuit that enables safe, long-term torpor in mice https://t.co/oFkeOaLxyv

[Manav Pathania | @manavpathania.bsky.social @Pathania_Lab]

https://t.co/uI3ahfW9zw

[Nature Biomedical Engineering @natBME]

CAR-neutrophils produced in vivo to treat glioma https://t.co/1djtvC794g

[Manav Pathania | @manavpathania.bsky.social @Pathania_Lab]

We're looking for a Senior Computational Postdoc to help us analyse our single-cell, spatial and epigenomics data from mouse models and to cross-reference these analyses with data from human tumours. Please get in touch if you're interested!

https://t.co/ANaTZva2g7

[Manav Pathania | @manavpathania.bsky.social @Pathania_Lab]

Anthropic cofounder says studying the humanities will be ‘more important than ever’ and reveals what the AI company looks for when hiring https://t.co/IXUKdg5gzU

[Manav Pathania | @manavpathania.bsky.social @Pathania_Lab]

We're seeking to fill two roles: a PDRA and an RA. These positions will investigate resistance mechanisms in brain tumour models using in vivo models, spatial omics, CRISPR. Please apply if previous experience aligns!

Here is the RA job advertisement: https://t.co/QGlKsyhZTg

[Manav Pathania | @manavpathania.bsky.social @Pathania_Lab]

We're seeking to fill two roles: a postdoc and a research assistant. Both will focus on resistance mechanisms in brain tumour models using various approaches (in vivo, spatial omics, CRISPR). Please apply if this aligns with your previous experience!

https://t.co/kwOJOidU18

[Jared Rosenblum @JaredRosenblum]

As promised, here's the deep dive on our recent article! Did you know the brain's "sewer drains" (dural sinuses) aren't passive pipes—they're dynamic, ruffling structures that actively guard immunity & regulate pressure?
As both a co-author and President & Founder of @neurosimplicity, I am excited to spotlight this groundbreaking discovery from the McGavern lab @NIH_NINDS in @Nature. Our Imaging Suite helped map the amazing cranial & neurovascular connections in unprecedented 3D detail! 🧠🔬
Link: https://t.co/S0vaaAT89P
#Neuroimmunology #BrainImmunity

[nature @Nature]

Nature research paper: Highly dynamic dural sinuses support meningeal immunity

https://t.co/770wKPbpto

[nature @Nature]

Nature research paper: A disease model resource reveals core principles of tissue-specific cancer evolution

https://t.co/jcdoxHpQtA

[Isaac Bogoch @BogochIsaac]

Step 1: Insert bacteria ("Wolbachia") into mosquitoes.

Step 2: Release mosquitoes.

Step 3: Watch Dengue rates plummet.

Phenomenal results from Singapore.

Link: https://t.co/6TZZf5EdIs, by Lim et al.

[Ayush Midha @AyushDMidha]

I am excited to share our latest preprint, in which we demonstrate that systemic hypoxia suppresses solid tumor growth.

This has been a tremendous collaborative effort in the labs of @IshaHJain and @Genophoria at @GladstoneInst, @ArcInstitute, and @UCSF.

https://t.co/bzsPY2nWVs

[Eric Topol @EricTopol]

3 new reports @CellCellPress on the mechanistic underpinnings of multiple sclerosis and Epstein-Barr virus involvement
https://t.co/JXThwhZugq
https://t.co/fO1aDsZmmB
https://t.co/fO1aDsZmmB

[Dr. Dominic Ng @DrDominicNg]

New Cell paper from the team that discovered glymphatic clearance (how your brain removes waste during sleep).

Sleep hours DIDN'T predict brain cleaning. Neither did REM or deep sleep.

They found what actually matters - and why some sleeping pills might undermine it 🧵

[Manav Pathania | @manavpathania.bsky.social @Pathania_Lab]

Please share or forward to anyone interested in joining our lab as a research assistant, details can be found via the link below

https://t.co/Jvh9a22NGN

[Manav Pathania | @manavpathania.bsky.social @Pathania_Lab]

Please share or forward to anyone interested in joining our lab for a postdoc, details can be found via the link below

https://t.co/xAhtakOvXo

[Manav Pathania | @manavpathania.bsky.social @Pathania_Lab]

Thanks to all those who helped us get going in Cambridge and looking forward to getting stuck in at Oxford soon!

[Manav Pathania | @manavpathania.bsky.social @Pathania_Lab]

The Pathania lab will be moving to the Ludwig Institute in Oxford in early 2026. We'll be recruiting postdocs and research assistants soon, so keep an eye out for those job ads and reach out if you want to find out more about the science we have planned!
https://t.co/DqQRW3zfbS

[Manav Pathania | @manavpathania.bsky.social @Pathania_Lab]

Farewell for Carmo, RA extraordinaire! Good luck in your PhD at the Crick and thanks for all your hard work over the last 3 years!