Patrick Honma

Postdoc @ Gladstone Institutes | UCSF Neuroscience PhD

[Patrick Honma @PatrickHonma]

I'll be presenting a poster on this work tomorrow at #SfN25. Details below:

Sunday (11/16), 1:00-5:00 PM
Presentation/Board Number: LBP033.14/LBP116

10/n

[Patrick Honma @PatrickHonma]

Excited to share our new preprint!

How do animals transform internal representations into step-by-step navigation to goals? Decoding these strategies directly from behavior is challenging because these internal states are not directly observable.

https://t.co/FZn0ANfBc7

🧵1/n

[Patrick Honma @PatrickHonma]

Thank you to my PI Jorge Palop, our collaborators and especially Shreya Bangera who was pivotal to the development of this project. Be on the lookout for her PhD program applications, as any program would be lucky to have her!

9/n

[Patrick Hsu @pdhsu]

Today in @NatureBiotech, we report engineered DNA recombinases with up to 53% integration efficiency and 97% genome-wide specificity at an endogenous human locus, inserting large DNA cargoes up to 12 kb for stable expression in primary human T cells, stem cells, and non-dividing cells

[Patrick Hsu @pdhsu]

🧵In new work, we report a systematic engineering roadmap to optimize large serine recombinases (LSRs) for direct, site-specific insertion into the human genome 🧬. We achieved over 50% insertion efficiency and 97% genome-wide specificity, a 10X improvement over our previous work

[Katerina Akassoglou @AkassoglouLab]

New paper by Jorge Palop's lab @CellReports we collaborated. We report a #MachineLearning platform for unbiased & sensitive behavioral analysis of #Alzheimers mice & protection from AD behavioral alterations by genetic #fibrin inhibition.
https://t.co/pDOf0IRESw

[Patrick Hsu @pdhsu]

Just shared at @KeystoneSymp a new @ArcInstitute discovery of the bridge RNA recombinase mechanism: a new class of natural RNA-guided systems that retains the key property of programmability from RNAi and CRISPR while enabling large-scale genome design beyond RNA and DNA cuts

[UCSF Bakar Aging Research Institute @UCSFAging]

Congratulations to our graduate student fellowship award recipients @PatrickHonma @MarikoFoecke @deannanecula @cayce_shaw Rebecca Fang and Viana Pham!!🥳🥳🎖️Very excited to work with you in the coming year!

[Katerina Akassoglou @AkassoglouLab]

Our paper “Microglia Gi-dependent dynamics regulate brain network hyperexcitabilty” is now online @NatureNeuro! By genetic inhibition of #microglia brain surveillance & directed motility, we found that microglia dynamics prevent hypersynchrony & seizures.
https://t.co/OZUJbxMdH6

[Patrick Honma @PatrickHonma]

Excited to share our perspective on the potential utility of the retina as a biomarker for Alzheimer’s Disease https://t.co/CiDMIM943f