UCSF Bakar Aging Research Institute

Our Institute brings together scientists and clinicians from all UCSF campuses to address the most critical and intractable questions related to Aging.

[UCSF Bakar Aging Research Institute @UCSFAging]

We bring together UCSF scientists and clinicians to uncover mechanisms behind aging, develop novel diagnostic/therapeutic tools, and establish best practices for providing equitable care to older adults in our communities. https://t.co/8kYEO8uiSK

[UCSF Bakar Aging Research Institute @UCSFAging]

Essential reading for dermatologists and clinicians! https://t.co/c61pin8G8G

[UCSF Bakar Aging Research Institute @UCSFAging]

Congrats to BARI’s Katrina Abuabara! New JAAD review outlines best practices for evaluating atopic dermatitis: clinical diagnosis, recommended severity tools, and the importance of standardized assessment for long-term disease control.

[UCSF Bakar Aging Research Institute @UCSFAging]

Thrilled for BARI’s Dengke Ma on new Nature Communications paper! High-population density in liquid triggers reversible suspended animation in C. elegans, complete metabolic & behavioral arrest across life stages. Game-changing dormancy model! https://t.co/t4CEcvRcwW

[UCSF Bakar Aging Research Institute @UCSFAging]

https://t.co/LUL8uNc5Bh

[UCSF Bakar Aging Research Institute @UCSFAging]

BARI is celebrating Max Krummel’s new Nature Immunology study! Most common mouse tumor models mimic only the macrophage-rich, T-cell-poor “cold” human tumors. Conserved T cell-myeloid gene programs predict better patient outcomes, a practical atlas for smarter cancer modeling.

[UCSF Bakar Aging Research Institute @UCSFAging]

https://t.co/y8wFU02hXV

[UCSF Bakar Aging Research Institute @UCSFAging]

Congrats to BARI’s Kevan Shokat on his new ACS Chem Biol paper! Targeting the protein-membrane interface with optimized lipophilic chains creates long-acting CFTR potentiators that sustain channel activation far longer after washout. Smart advance for cystic fibrosis therapy!

[UCSF Bakar Aging Research Institute @UCSFAging]

https://t.co/VmRoQX6TM3

[UCSF Bakar Aging Research Institute @UCSFAging]

Proud of BARI’s Dean Sheppard on his new Thorax paper! Circulating CTHRC1 levels (a marker of pathological fibroblasts) are elevated in IPF and strongly predict disease severity, faster progression, and reduced transplant-free survival. Promising new biomarker!

[UCSF Bakar Aging Research Institute @UCSFAging]

Thrilled for BARI’s Michelle Arkin on her new PNAS paper! Molecular glues restore the broken 14-3-3/CRAF interaction in Noonan syndrome, normalizing MAPK signaling. Promising approach for RASopathies! https://t.co/Vlm2499zv3

[UCSF Bakar Aging Research Institute @UCSFAging]

Huge congrats to BARI Director Leanne Jones on her induction into the Academy of Geroscience! One of 16 leading scientists recognized for advancing the biology of aging. Proud to see her recognized for driving discoveries for healthier longevity! https://t.co/ytO0taSaiw

[UCSF Bakar Aging Research Institute @UCSFAging]

https://t.co/GXMyUaL5Gg

[UCSF Bakar Aging Research Institute @UCSFAging]

Check this out from BARI’s Martin Kampmann: His team grew human brain cells with a mutation that causes frontotemporal dementia. The mutant tau protein led to shorter axons, similar to removing tau. Interesting work that could point to pre-symptom neuronal changes.

[UCSF Bakar Aging Research Institute @UCSFAging]

https://t.co/qvM2HrzsDQ

[UCSF Bakar Aging Research Institute @UCSFAging]

Great work from BARI’s Todd Nystul! He shows aging fly ovaries struggle because the surrounding support cells start to fail, they don’t wrap eggs properly, accrue DNA damage, and have trouble dividing. But turning up an autophagy gene nearly doubles egg-laying in older flies!

[UCSF Bakar Aging Research Institute @UCSFAging]

Congrats to BARI’s Dena Dubal and team! Their new study links the longevity gene klotho to better executive cognition in early Parkinson’s. Mouse studies show klotho counters α-syn toxicity, extends lifespan & rescues memory. Promising work! https://t.co/cAxHwxaEve

[UCSF Bakar Aging Research Institute @UCSFAging]

https://t.co/piruetLwRm

[UCSF Bakar Aging Research Institute @UCSFAging]

Congratulations to BARI’s Michelle Arkin! She has been elected as a new member of the American Academy of Arts and Sciences, one of the nation’s most prestigious honors. A well-deserved recognition of her groundbreaking work in pharmaceutical chemistry and drug discovery!

[UCSF Bakar Aging Research Institute @UCSFAging]

New insights into protein quality control in neurodegeneration.
https://t.co/SQGUpJg3CQ

[UCSF Bakar Aging Research Institute @UCSFAging]

Interesting work from BARI’s Martin Kampmann & team! They show an Hsp40 cochaperone suppresses toxic polyglutamine aggregates (key in Huntington’s disease), with context-dependent effects on polyglycine too.