Pengbiao Xu

Working on innate immunity and structural biology.
@EMBO Postdoc scholar @EPFL
Ph.D. @TAMU @TAMUBCBP

[Pengbiao Xu @PengbiaoX]

Check out our new publication on the fate of cGAS in cycling cells! https://t.co/hwwgXb0w0G It has been established that cGAS enters the nucleus and tethers to nucleosomes during mitosis. However, what is the ultimate fate of nuclear cGAS? 1/n

[Pengbiao Xu @PengbiaoX]

@MartinPacesa @Nature @CasperGoverde @GoldbachNico @befcorreia Awesome work, congrats Martin!

[Martin Pacesa @MartinPacesa]

Today in @Nature we present the results of our exploration of the soluble protein universe and the design of functional soluble membrane proteins with @CasperGoverde @GoldbachNico @befcorreia 1/6

https://t.co/Dakeh8Hyw7

[Prof. Hao Wu @WuLabHarvard]

Exited to share our new paper by Gang Du @ , Liam @L_Heals, Liron David @LironDavid2 and others on GSDMD palmitoylation. “ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D” in Nature https://t.co/4cetT0PdCM. Even full-length GSDMD can form pores!

[Pengbiao Xu @PengbiaoX]

@The_PW_Lab @TheBrysonLab Amazing! Is it possible to search directly in the UCSC browser for another dataset like STING agonist, Or we have to find the paper first, then link?

[Hironori Funabiki @HironoriFunabi1]

Pleased to share our News & views article (with my postdoc Calvin Jon Leonen) highlighting the recent Nature article by @PengbiaoX , Andrea Ablasser and colleagues on nuclear cGAS degradation.
https://t.co/hbPpAvlxZp

[nature @Nature]

Nature research paper: The CRL5–SPSB3 ubiquitin ligase targets nuclear cGAS for degradation https://t.co/5amxgjL5Dh

[Pengbiao Xu @PengbiaoX]

As always, many thanks to @DCI_EM @AlexmagCryo for the extremely high-quality CryoEM data collection and @EMBOFellows for my postdoctoral grant!

[Pengbiao Xu @PengbiaoX]

Check out our new publication on the fate of cGAS in cycling cells! https://t.co/hwwgXb0w0G It has been established that cGAS enters the nucleus and tethers to nucleosomes during mitosis. However, what is the ultimate fate of nuclear cGAS? 1/n

[Pengbiao Xu @PengbiaoX]

🚀 Ready to take on new challenges as a Group Leader! 👥 Passionate about leadership and team collaboration. If you know of any exciting opportunities or have insights into roles matching my expertise, please share. Let's embark on this journey together!

[Pengbiao Xu @PengbiaoX]

@Ella_Maru Good point, more mechanism of nuclear cGAS is under investigation

[Pengbiao Xu @PengbiaoX]

@The_PW_Lab Thank you, Robbie! I truly appreciate your kind words. Exploring opportunities and considering all options. Your encouragement means a lot!

[Max Planck Institute of Biochemistry (MPIB) @MPI_Biochem]

Now out in @MolecularCell! High-res structure showing direct #ubiquitylation of a #TPD substrate!
❕ https://t.co/4XJx2czfXx

#cryoEM @UNLV_CoS @JoannaLiwocha @DanielS2012197

Complementary study from @alessiociulli & @CharlCrowe https://t.co/EWZ6Vr8UCl
@UoDCeTPD @UoDLifeSciences

[Pengbiao Xu @PengbiaoX]

@newyorkdimka a snake, yes!

[Pengbiao Xu @PengbiaoX]

🎉 We are thrilled to announce the release of the latest structure of the #cGAS complex in PDB as https://t.co/WpAGGpgm9b🌐✨Stay tuned for the full story in our upcoming paper, where we unveil the secrets behind cGAS transportation and its ultimate destiny. #Immunity