Riccardo Percudani 🐳

Father of Eva and Adele, husband of Ariane. Teacher and researcher at @unipr: biochemistry & bioinformatics, metabolic pathways, coevolution.

[Riccardo Percudani 🐳 @Percud]

Over a century after Garrod's pentosuria, we found how L‑xylulose is formed in the pentose pathway via coevolutionary analysis of KEGG networks. A long-standing metabolic gap bridged in @PNASNews. #Bioinformatics #Genomics #Biochemistry #Metabolism https://t.co/iPIhrbUmxz

[Lifemetabolism2 @lifemetabolism2]

Research highlight @Percud: Urate metabolism, in the gut https://t.co/9JoArKR3mL

[Riccardo Percudani 🐳 @Percud]

A novel component of the CatSper ion channel (Armh2) uncovered! Great collaboration with @JeanJuChung and @jianpingwu8
https://t.co/E5kk5nKLoD

[Riccardo Percudani 🐳 @Percud]

Great new machine learning study from @unipr researchers:
Read it here 👉 https://t.co/whAIzGBaHT

[Riccardo Percudani 🐳 @Percud]

Michael Galperin @MicroGap is a wizard. How did he know?

[Riccardo Percudani 🐳 @Percud]

Using bioinformatics for identifying and plugging metabolic pathway holes | PNAS https://t.co/FXo82efjQH

[Nature Biotechnology @NatureBiotech]

Deep-learning-based single-domain and multidomain protein structure prediction with D-I-TASSER https://t.co/tGzmixoQYq

[Riccardo Percudani 🐳 @Percud]

Predicting Protein Function in the AI and Big Data Era | Biochemistry https://t.co/OvEEtdCTue

[antisense. @razoralign]

EvoWeaver provides as output its 12 predictions for signals of coevolution, and can optionally provide an ensemble prediction using built-in pretrained models. Functional associations often result in correlated gain/loss patterns on a reference phylogenetic tree.

[The Nobel Prize @NobelPrize]

"It's not a goal that is the goal, it's actually the path towards the goal."

2014 chemistry laureate Stefan Hell shares his best career advice for young scientists and researchers.

#NobelPrize

[Roberto Steiner @steiner_lab]

Will soon open a position in my group in Padova. Topic is mechanistic enzymology with cool serial X-ray, electron and neutron crystallography work... plenty of opportunities for collaborations with leading groups. Get in touch with me [email protected] if interested.

[Riccardo Percudani 🐳 @Percud]

Pierre-Régis Burgel presenting the keynote speech at the 22nd convention of investigators in Cystic Fibrosis.

[Riccardo Percudani 🐳 @Percud]

Mitochondria never cease to amaze

[nature @Nature]

How do mitochondria, the cell’s energy-producing organelles, perform competing metabolic processes?

Segregation into distinct populations — one that makes energy-storing ATP molecules and one that does not — could explain it

https://t.co/McNw5KrKC6

[Riccardo Percudani 🐳 @Percud]

@ditlevbrodersen the diet of your ancestors wasn't so bad after all!

[PNASNews @PNASNews]

Ancient Danes harvested oysters sustainably for around 3,000 years, from 5660–2600 BCE, according to examinations of shells at 19 archeological sites. Oyster size decreased in the Neolithic, indicating an increase in harvesting pressure. In PNAS: https://t.co/pUpQSc1iUQ

[Riccardo Percudani 🐳 @Percud]

And the #localBLAST is better

[Riccardo Percudani 🐳 @Percud]

Our #bioinformatics course assistants love using ChatGPT visuals in the computer lab exercises. I found this #BLAST visual quite punching!

[Riccardo Percudani 🐳 @Percud]

@stevenstrogatz d6xf4

[The Nobel Prize @NobelPrize]

This year’s medicine laureates Victor Ambros and Gary Ruvkun studied a relatively unassuming 1 mm long roundworm, C. elegans.

Despite its small size, C. elegans possesses many specialised cell types such as nerve and muscle cells also found in larger, more complex animals, making it a useful model for investigating how tissues develop and mature in multicellular organisms.

Read how the 2024 medicine laureates’ investigations into C. elegans revealed an entirely new dimension to gene regulation: https://t.co/8RwUplwYQA

#NobelPrize

[Niko McCarty. @NikoMcCarty]

Link: https://t.co/r4X7es66My

Also, I previously tweeted about this story, so you may have already heard about it. https://t.co/CEZuQCPNIK

[Riccardo Percudani 🐳 @Percud]

High-resolution cryoEM structure of UapA, the original member of the NAT transporter. While UapA transports uric acid, other members of this family transport ascorbate. Linus Pauling proposed an evolutionary connection between uric acid and ascorbate (vitamin C)

[Gatsogiannis Lab @GatsogiannisLab]

📢New lab preprint: 2.05 A #cryoEM structure of UapA: unprecedented aspects of the elevator-type transport (incl. water, lipids) and regulatory roles of the N-tail. With Diallinas, Mikros labs. Kudos @broutzakis and all co-authors. @uni_muenster #SoN
https://t.co/XzGOSkbNg4