Ashley Ferrier

[Ashley Ferrier @PerryFerrier]

https://t.co/Ir0py4GJsB

[Ashley Ferrier @PerryFerrier]

https://t.co/Ir0py4GJsB

[Ashley Ferrier @PerryFerrier]

https://t.co/rnN7x7m843

[Ashley Ferrier @PerryFerrier]

https://t.co/MCDdEmT24O

[Ashley Ferrier @PerryFerrier]

https://t.co/MCDdEmT24O

[Ashley Ferrier @PerryFerrier]

@Gac664 @_caroscha Oie Gac, vas Hawaii? 👀

[Ashley Ferrier @PerryFerrier]

@_caroscha Le amé

[Alejandro Montenegro @aemonten]

PhD and MD/PhD

[Maarten van Smeden @MaartenvSmeden]

It is the only way

[Professor Booty PhD @ProfBootyPhD]

I think we need to talk about how devastating this cancer microbiome refutation paper from
@StevenSalzberg1
and colleagues is. It really speaks to how devoid of critical thinking and intellectual depth our glam publishing ecosystem has become. 1/n
https://t.co/wWsHTa4K8x

[Veera Rajagopal  @doctorveera]

A mind-blowing paper has come out today in @Nature

In 2016, JC Venter Institute scientists trimmed a bacterial genome to its barest minimum required for life to synthesize what they called a "minimal genome" (https://t.co/Rk8oZJ0bUj).

Today, a group of scientists from Indiana University reports how that minimal genome evolved over 2000 generations in comparison to the non-minimal genome.

The authors found that even when you reduce a bacterial genome to its absolute minimum where every nucleotide matters, the genome undergoes mutational events generation after generation as much as the non-minimal genome. One simply cannot stop the evolution.

Just over 300 days of evolution (equivalent to 40,000 years in humans) the minimal cell has gained everything it lacked in fitness on day one in comparison to the non-minimal cell.

When comparing the evolved traits between the minimal and non-minimal cells, the scientists found something striking. The evolutionary process increased the cell size of non-minimal cells but not that of the minimal cell. But that is not the striking part.

The scientists were able to identify the key mutation that resulted in cell size evolution. And it turned out that the mutation that helped the non-minimal cells to grow bigger is the same that helped the minimal cells to stay smaller. Growing bigger had a survival advantage for non-minimal cells and not growing bigger had a survival advantage for minimal cells. So, the mutation had a context-dependent effect. This just demonstrates that the evolutionary effects on traits have no absolute direction. All that matter is what is beneficial for the organism's survival.

The conclusion of the paper is metaphorically a quote from the Jurassic Park movie:

“Listen, if there’s one thing the history of evolution has taught us is that life will not be contained. Life breaks free. It expands to new territories, and it crashes through barriers painfully, maybe even dangerously, but . . . life finds a way". (https://t.co/UlxRlb86CT)

https://t.co/zA9OAqSoAu

[Ashley Ferrier @PerryFerrier]

@_caroscha Caché que era por las AI, por el scraping de datos

[Ashley Ferrier @PerryFerrier]

@_caroscha Meo tema oee, se vacila con todo

[Moisés Gallo Ávalos @moisesgallo]

La misma noticia, dos formas de presentarla.

Una te mete las complejidades del descubrimiento (ven que se puede?).

La otra es puro clickbait.

[Sketching Science @sketchscience]

I hated doing PCRs 🧬 as an undergraduate… Now, as a postdoc, I’ve done thousands of PCRs 🧬… Here are 10 tips to do perfect PCRs:

[Journal of Cell Biology @JCellBiol]

A live-cell marker to visualize the dynamics of stable #microtubules throughout the cell cycle. From Klara Jansen, Malina Iwanski @mkiwanski, Mithila Burute and Lukas Kapitein @KapiteinLukas @UniUtrecht: https://t.co/AoGfNPzAa6

#Technology #Cytoskeleton

[ErrantScience @ErrantScience]

You are valid. You are enough. You are doing the best you can. 🌻
#cartoon #academia #science

[Niko McCarty. @NikoMcCarty]

Synonymous mutations have massive effects on protein activity. Never knew that.

Take a protein & make a fast + slow-translated version.

For one enzyme, fast translation caused 20% drop in activity. Simulation + experiments show "entangled states." Weird. https://t.co/snaApqsF6A

[Ashley Ferrier @PerryFerrier]

@carojimena Sip, con harto hielo los pidió