The Gordon center started the new year with a new biological emphasis under new leadership: @MatthiasNahrend is our new director. Umar Mahmood will lead a technology-focussed sibling, the Center for Nuclear Medicine & Theranostic Sciences.
Excited to share that our group received another R01! A postdoc opportunity is available to develop new diagnostic and therapeutic approaches for liver fibrosis. Join us! https://t.co/lLlcSiKh3k https://t.co/hq9Le36IuN
#livertwitter#ScienceJobs#PhD#postdocjobs#postdocposition
Noninvasive Quantification of Radiation-Induced Lung Injury using a Ta... https://t.co/vrVqz6MkwW. Great collaboration with Eric Abston and @MGHSurgery on using #MolecularImaging for early detection of radiation induced #fibrosis and monitoring treatment response
Despite all that Gd, there were no histological signs of kidney damage. Would be worth testing if this is true in older rats or those with prior kidney injury. End
This paper from @Mariane_LeFur had 3 provocative findings. 1. Gadolinium retained in kidneys is invisible to T1w MRI until it is present at high 100s of micromolar. Gd is retained in kidneys at several orders of magnitude more than in brain. #Kidney 1/6
Following administration of four different gadolinium contrast agents to healthy rats, mass spectrometry showed the highest concentration in the kidney cortex at day 17. @PeterCaravan @Mariane_LeFur @MGHMartinos @MGH_RI @i3MGH https://t.co/baZg0f62gG
3. At 7-8 weeks after dosing the gadolinium retained in the rat kidneys was intact chelate. This was true of all 4 compounds tested including the linear chelate gadobenate. 5/6
We're thrilled to present our latest work on #ovariancancer detection through the analysis of #extracellularvesicles . We delved into the fallopian tube to identify early lesions. @MGHCSB @MGH_RI https://t.co/6E6ELnTNi3
New from @VeronicaClavij8 @sojoodi_mozhdeh and Eric Gale: Molecular Magnetic Resonance Imaging of Liver Inflammation Using an Ox... https://t.co/nCOV5JyY70. #liver#NAFLD#DILI@MGHMartinos @MGH_RI @MghNafld
Nice work from Phil and Iris and a great collaboration with Bryan Fuchs, Bob Colvin @MGHKidneys and @pfizer colleagues to image fibrotic disease activity in the kidneys
In most CKDs, lysyl oxidase oxidation of collagen forms allysine side chains, which then form stable crosslinks. This study shows MRI using Gd-OA is potentially a valuable tool for detecting and staging renal fibrogenesis https://t.co/UZeowVbWNi
@PeterCaravan@i3MGH