What does it take to develop a quality-control platform for phage production?
In our conversation with Ville Hoikkala, we discuss *BatchQC* and the challenges of developing software that must be scientifically accurate, reproducible, and suitable for a regulated environment.
How do we ensure the integrity and purity of bacteriophage preparations?
Genome inconsistencies and batch-to-batch variability are important challenges for phage production. We discuss how bioinformatics can contribute to quality control with Ville Hoikkala from @PrecisionPhage
New Phagecast episode — Episode 32!
We speak with Ville Hoikkala, researcher, bioinformatics team leader and co-founder a at @PrecisionPhage , about phage genome integrity, quality control, and the challenges of ensuring reliable phage production.
How do phages recognize their bacterial hosts?
We discuss receptor-binding proteins, phage specificity and the molecular mechanisms underlying phage–host recognition with Lone Brønsted.
A fundamental question with major implications for understanding and engineering phages.
We also discuss how to retain talented researchers, balance the pressure to publish with high-quality science, and protect mental health throughout the process.
Enjoy the episode!
How do you create a research environment where people feel safe to make mistakes? And how do you balance publishing pressure, scientific quality and mental health?
In this episode, we speak with @LNdsted Professor at the University of Copenhagen.
https://t.co/dZOc3dc6w6
The conversation then moves beyond phages: what does scientific excellence actually mean?
We talk about research culture, leadership, communication, responsibility and creating an environment where people can make mistakes, especially during difficult periods.
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After many years in academia Dr. Yang Shen transitioned to industry to continue studying phages.
At the end of the episode, he shares what he finds different between industry and academia, his advice for early-career scientists and much more on career and personal resilience!
Delivering phages in aquaculture isn’t as simple as adding them to water.
How do phages reach their targets?
Are cocktails necessary?
What about dilution, stability and bacterial resistance?
We discuss the challenges of phage therapy in aquaculture on PhageCast.
Custus®️YRS is the world's first commercial bacteriophage product developed for aquaculture.
How does it work?
Why was Yersinia ruckeri chosen as the first target?
And what have we learned from bringing phage therapy into commercial fish farming?
https://t.co/x11FLS877b
How are antibiotics used in aquaculture?
How strict are the regulations? Which bacterial infections still require treatment? And where could phages make the biggest impact?
We discuss all of this with Yang Shen R&D Director at ACD Pharma:
https://t.co/x11FLS877b
We speak with Dr. Yang Shen, R&D Director at ACD Pharma.
Have you ever wondered how aquaculture works and why bacteriophages are needed in fish farming? How are phages actually used in this industry?
Find out in our 30th episode!
https://t.co/x11FLS877b