Pieter Goossens lab

Pieter Goossens lab at the Maastricht University, #macrophage #inflammation #atherosclerosis

[Pieter Goossens lab @PiGoossensLab]

Excited to participate in this fantastic project!

[The Global Cardiovascular Research Funders Forum @The_GCRFF]

🚨BIG NEWS: Global research network to launch SHE‑HEALS study with US $10m from the GCRFF – aiming to advance our understanding of how menopause shapes heart health.🔗Read more: https://t.co/vjOAnFc0M1 #internationalresearchchallenge #globalcollaboration #womenscvdhealth

[Ziad Mallat @ZMallat]

Thrilled to coordinate SHE-HEALS. We’ll study how perimenopause and early menopause shape heart disease risk and test whether earlier prevention can stop silent Atherosclerosis before symptoms begin. @Cambridge_Uni @UniMelb @Cambridgecardio @HLRI_Cambridge @parcc_inserm

[Huveneers Lab @Huveneers_Lab]

Interested in research on cell-cell junctions and vascular biology? We are recruiting a PhD student!

https://t.co/0jj6rKv9Vb

[Pieter Goossens lab @PiGoossensLab]

Thanks a lot to Jack Cleutjens for making our lab a safer place by giving us a hands-on CPR & AED training this morning! Will you also do this in your lab? @CARIMMaastricht @Hartstichting @mumc @maasuniversity See https://t.co/qa85J3Rikj

[Pieter Goossens lab @PiGoossensLab]

A healthy and successful 2025 to you all from our team (@LLauraxk missing on the picture)! May it be more colorful than our dresscode 😉

[Pieter Goossens lab @PiGoossensLab]

I also brought a poster to #EMDS2024, come and watch today how MafDKO #macrophages reduce atherogenesis, with @SiewekeLab @SarrazinSand @BelaWieland (poster 23) @CARIMMaastricht

[Elias Wieland @BelaWieland]

Come and visit my poster #75 today at the @EuMacDcSoc #EMDS2024 meeting. We are presenting our recent work on #DC heterogeneity in #melanoma draining lymph nodes #SLN

[Pieter Goossens lab @PiGoossensLab]

It's the most wonderful time of the year... #EMDS #EMDS2024 #Vienna #macrophages @EuMacDcSoc

[Pieter Goossens lab @PiGoossensLab]

@KroonLab @NWO_Science @amsterdamumc @KU_Leuven @CarmelietLab Proficiat!!

[EU-MIRACLE Doctoral Network @EU_MIRACLE]

The MIRACLE DN officially kicked off with a successful meeting in Amsterdam! Partners, doctoral candidates, and experts came together to launch the next phase of research into cardiometabolic diseases.
🔗 Read the full recap here: https://t.co/6UwBodd316

[Lab of Michael Sieweke - LoMiS @SiewekeLab]

🔁 Super exciting to see this collaboration take off! 🚀 Amazing work from @BelaWieland, @pigoossenslab and @SarrazinSand studying #macrophage behavior in #atherosclerosis
🔬🧫 Can’t wait to follow the progress on this #CVD research! 💥 #TeamScience

[Sandrine Sarrazin @SarrazinSand]

🚀 The last few weeks we've been teaming up with @BelaWieland from @PiGoossensLab
to set up functional assays in vitro, studying our favorite cells’ behavior in atherosclerosis context!
🔬🧫 Get ready for exciting #macrophage 🧡 #CVD research! 💥
@SiewekeLab @CIML_Immunology

[Pieter Goossens lab @PiGoossensLab]

Cool view on our recent paper, thank you @ImmunoSketch !

[ImmunoSketch @ImmunoSketch]

Targeting and removing specific cells from plaque areas, like towing cars from a traffic jam, effectively reduces artery blockages.

@BelaWieland @PiGoossensLab @temmerman_lieve @CARIMMaastricht @MaastrichtUMC @MaastrichtU @EurJImmunol

https://t.co/2kizl8WLSV

[Pieter Goossens lab @PiGoossensLab]

Depleting CSFR1+ cells alters monocyte landscape and atherogenesis. Congratulations @BelaWieland ! @CARIMMaastricht @Hartstichting @MaastrichtU https://t.co/uyziGZ7M4t

[Pieter Goossens lab @PiGoossensLab]

Congratulations to @BelaWieland for winning the #DAS @AtheroNL best poster award! @CARIMMaastricht @Hartstichting #Mafia

[IdoAmitLab @IdoAmitLab]

Macrophage and DC enthusiasts, you don't want to miss this extraordinary meeting co-organized with @SylviaKnapp_Lab, @FGinhoux and @deVisserKarin

[Pieter Goossens lab @PiGoossensLab]

Looking forward to @ValeriaSaar 's PhD defense in just two hours from now, join us live or via https://t.co/EEp4l12nHF @CARIMMaastricht @IMcarim

[CARIM @CARIMMaastricht]

#thesisdefence Tomorrow, Daniëlle Kerkhofs will defend the thesis 'Inflammatory cells and blood-brain barrier leakage in cerebral small vessel diseases' at 10:00h @MaastrichtU

📺https://t.co/GPpyNounJH

#phdlife @S_Foulquier

[Nick Norwitz MD PhD @nicknorwitz]

8 hour time-restricted eating linked to 91% higher risk of cardiovascular death? 🫀

Really?! Not so "fast" ...🤔

Upon popular request, I'm covering this news release.

👉 1) This is not in reference to a published paper.

Rather, these were "preliminary" results presented at an AHA epidemiology conference. The paper that these data may yield is not published, so informed commentary is necessarily limited.

👉2) The article notes, "Previous research has found that time-restricted eating improves several cardiometabolic health measures, such as blood pressure, blood glucose and cholesterol levels." They also provide no biologically plausible rationale for the results.

👉3A) The results themselves were based on self-report...

This doesn't invalidate the data itself (I'm not against questionnaires); however, in the context of findings that are at odds with other data (as noted above) and absence of presented biological plausibility, and high probability of reporter bias (e.g. perhaps people with higher risk factors and more clinical clinical 'concern' are more likely to report trying 16-8), I would take this with a grain of salt (but not too many grains... because that will raise your blood pressure... with TRF helps, btw).

3B) "Time-restricted eating was determined on the basis of just two days of dietary intake”

3C) Also "the nutrient quality" was not assessed

4) Not all elements of the news coverage were clear/consistent. E.g. "Among people with existing cardiovascular disease, an eating duration of no less than 8 but less than 10 hours per day was also associated with a 66% higher risk of death from heart disease or stroke." Is this saying in those with CVD <8 was okay, but <10 was bad? That's odd and a little "sus" (as the kids say)

And, in closing, it's worth noting the news article itself says "The Association makes no representation or guarantee as to their [the data's] accuracy or reliability."

I'll continue to skip breakfast as it suits me.

You do you.

cc' @MatthewNehsMD @ChrisPalmerMD @drjasonfung @bigfatsurprise @DoctorTro @KenDBerryMD @AdrianSotoMota anything to add?

You gonna' pick up some Cheerios for your heart?

[Pieter Goossens lab @PiGoossensLab]

Consider coming to work in the Netherlands and profit from Maastricht University's excellent #MSCA support!