Piers Klein

Researcher @The_BMC, @BUMedicine. Past @NEIDL. Views my own.

[Mass General Brigham/HMS Neurology Residency @harvardneuromds]

We are THRILLED to announce and welcome our newly matched residents for the MGB Adult Neurology Class of 2030 and MGH Pediatric Neurology class of 2031!

Congratulations to everyone and we cannot wait to meet you!! 🥳🎊🎉

#nmatch2025 #neurology #match #harvard

[Stroke AHA/ASA @StrokeAHA_ASA]

Is First-Line Stenting in Patients With Ischemic Strokes Better Than Rescue Stenting?

In this #BloggingStroke post, @MaddyRussell16 discusses #Stroke article by @AaronCalienes & @dyavagal et al. #ISC26 @AHAScience

https://t.co/aadgHOyuHs

[Stroke AHA/ASA @StrokeAHA_ASA]

#ISC26 In a retrospective observational cohort study, first-line stenting and rescue stenting during EVT for AIS demonstrated a comparable safety and effectiveness profile. @AHAScience https://t.co/QMJ25q5PUv

[Stroke AHA/ASA @StrokeAHA_ASA]

Check out "Dissecting Aneurysm in Cervical Artery Dissection: Insights from the STOP-CAD Study," presented today at #ISC26. https://t.co/iEPwGxLbUZ

[Stroke AHA/ASA @StrokeAHA_ASA]

🧵In the STOP-CAD cohort, dissecting aneurysms occurred in ~14% at baseline, mostly within 6 months. These were linked to connective tissue disorders, fibromuscular dysplasia, and multivessel dissection, but not to higher risk of ischemic stroke or ICH. #ISC26 @AHAScience

[NeuroNews @NN_publishing]

Patients who developed an aneurysm with a cervical artery dissection—particularly young adults—did not experience an increased stroke risk within six months after diagnosis, as per study data set to be presented at #ISC26
@American_Stroke @LD_McCullough
https://t.co/7FY45Eui4Y

[Aaron Rodriguez Calienes @AaronCalienes]

Our comparative sub-study from the RESISTANT registry showed similar clinical outcomes and hemorrhage risk whether intracranial permanent stenting was used as a rescue strategy or as a first-line approach.

Our most recent study in @StrokeAHA_ASA:

https://t.co/OHBjAhuDo5

[Shadi Yaghi @ShadiYaghi2]

Excited to share this secondary analysis of STOP-CAD. Recurrent dissection is rare (1-2% per year) and only 3% of those had a #stroke. Factors associated with higher risk were young age, FMD, & migraine. Check out the full manuscript. 🛑CAD @StrokeAHA_ASA https://t.co/jKRI2jJYuP

[Stroke AHA/ASA @StrokeAHA_ASA]

🧵BIORISK ICAS study (35 sites) showed that imaging markers of impaired distal perfusion (e.g., borderzone infarcts and hypoperfusion mismatch) were independently associated with higher 90-day recurrent stroke risk in symptomatic intracranial atherosclerosis.

[Michele Romoli @MicheleRomoli]

🧵 How should we manage anterior circulation tandem lesion #stroke during #thrombectomy (EVT)?
In a large international cohort, we studied whether emergent carotid stenting (eCAS) improves outcomes 🔰
🔗 to @GreenJournal https://t.co/jFnseQ7hrQ

[Mohamad AbdalKader @AbdalkaderMD]

Seeing jugular stenosis in a patient with pulsatile tinnitus? Think twice before calling it the culprit.

In this case-control analysis of 246 patients, IJVS was equally common in PT patients and controls.
@TheAJNR @PiersKlein @NguyenThanhMD

https://t.co/zatzvQUob6

[Hesham Masoud @HMasoud_]

@svinsociety #SVIN25 served up cutting-edge science, impressive speakers, hands-on technical suites & open workshops. The cherry on top? Quality time with #SVIN family together! Congratulations to @esamaniego & the organizing committee, can't wait for #SVIN26 when #LasVegas turns #SVINCITY 🎰

@SVINJournal @YoungNIR @MThrombectomy @NN_publishing @WomenInNeuroIR @StrokeAHA_ASA @NguyenThanhMD @FazalZaidi9 @elghanemmoh @fahadlagharimd @AmuluruKrishna @almuftifawaz @JayDoliaMD @uclahealthmsu @PiersKlein

[NEJM @NEJM]

Original Article: Medical Management and Revascularization for Asymptomatic Carotid Stenosis (CREST-2) https://t.co/ZHLCV9ukNU

Editorial: Managing Asymptomatic Carotid Stenosis https://t.co/dLgi1iv8v0

#SVIN25 | @svinsociety

[Piers Klein @PiersKlein]

Low pressure but not risk free - Dr. Mohamad Abdalkader presents on identification and treatment of complications during venous endovascular interventions. #SVIN25

[NEJM @NEJM]

Presented at #SVIN25:

CREST-2: In high-grade asymptomatic carotid stenosis, addition of stenting to medical therapy led to a lower risk of stroke over a 4-year period. Endarterectomy did not lead to a significant benefit. Full results: https://t.co/ojge1CjqiU

Editorial: Managing Asymptomatic Carotid Stenosis https://t.co/D9LH89Edyk

@svinsociety

[Stroke AHA/ASA @StrokeAHA_ASA]

In an observational cohort study, unwitnessed patients with LVO undergoing EVT had at least the same likelihood of favorable outcomes as witnessed patients when presenting in the extended time window. https://t.co/vsT1TsUEKK

@PrCCordonnier @NguyenThanhMD @NagelSimon @shadiyaghi2

[International Journal of Stroke @IntJStroke]

🧠Study of patients who underwent intracranial stenting after EVT found no differences between those with vs. without IVT in:

🗓️90-day mRS shift
🗓️90-day mortality
🕐 24h sICH rates

Read more here👇
https://t.co/n24CGgcs2P

[Stroke AHA/ASA @StrokeAHA_ASA]

🧵Simultaneous publication at #WSC2025 🟢🔵The BIORISK ICAS study found that biomarkers of impaired distal perfusion — specifically borderzone infarcts and hypoperfusion mismatch — are linked to a higher risk of 90-day recurrent ischemic #stroke in patients with symptomatic ICAS.

[Shadi Yaghi @ShadiYaghi2]

Early recurrence in medically treated patients with symptomatic ICAS is driven by impaired distal perfusion. Happy to share that the BIORISK ICAS study was presented at WSC and published in stroke. I am grateful for our collaborators from across the world. https://t.co/wAnHhGvUPp

[European Stroke Org @ESOstroke]

🚨 Landmark Data Drop! At #ESOC2025, the CERES-TANDEM study - the largest real-world analysis on emergent carotid stenting during thrombectomy for tandem lesion stroke. 👥 4053 patients | 49 stroke centers ➡️ Improved outcomes, no excess bleeding risk
#Stroke @micheleromoli