Powers Lab

Student run profile for the Powers Lab at Texas A&M

[Powers Lab @Powers_Lab]

Congratulations to Dr. Samya Samanta (@iamsamya96), Ph.D. #15 from Powers group. Samya has been a leader in the group with his expertise in methodology development as well as being a mentor to several students in the lab. We are excited to see him shine in his future endeavors.

[Powers Lab @Powers_Lab]

Now live in TETL! We have introduced N-phenothiazinium amine salts as stable, tunable precursors for generating N-centered radicals. Providing a new route to aminyl radicals for use in C–N bond-forming reactions. Congrats to @iamsamya96 and coworkers.
https://t.co/bjrwm9i6In

[Powers Lab @Powers_Lab]

Our latest review by @arpanpaikar95 explores advances in metal nitrene and imido complexes for N-group transfer chemistry, detailing new synthetic strategies, reactive intermediates, and their roles in catalysis. Read more:
https://t.co/74kmiWvk9o

[Ambeed Inc @ambeedinfo]

🎉 𝐂𝐨𝐧𝐠𝐫𝐚𝐭𝐮𝐥𝐚𝐭𝐢𝐨𝐧𝐬 𝐭𝐨 𝐃𝐚𝐯𝐢𝐝 𝐂. 𝐏𝐨𝐰𝐞𝐫𝐬, 𝐒𝐚𝐦𝐲𝐚 𝐒𝐚𝐦𝐚𝐧𝐭𝐚, 𝐋𝐚𝐮𝐯 𝐏𝐚𝐭𝐞𝐥, 𝐃𝐢𝐲𝐚𝐬𝐡𝐚 𝐌𝐚𝐧𝐧𝐚, 𝐚𝐧𝐝 𝐌𝐞𝐥𝐢𝐬𝐬𝐚 𝐎𝐣𝐞𝐝𝐚 𝐨𝐧 𝐭𝐡𝐞𝐢𝐫 𝐧𝐞𝐰 𝐉𝐀𝐂𝐒 𝐩𝐮𝐛𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧: “𝐁𝐚𝐬𝐞-𝐅𝐫𝐞𝐞 𝐂-𝐍 𝐂𝐫𝐨𝐬𝐬-𝐄𝐥𝐞𝐜𝐭𝐫𝐨𝐩𝐡𝐢𝐥𝐞 𝐂𝐨𝐮𝐩𝐥𝐢𝐧𝐠”!

📖 https://t.co/lbC5idxcU2

🔬 This study introduces a nickel-catalyzed base-free C-N cross-electrophile coupling (XEC) strategy that enables efficient C-N bond formation by coupling electrophilic carbon and nitrogen partners under mild conditions.

🔹 A philicity-mismatched Ni-catalyzed C-N cross-electrophile coupling was developed using electrophilic carbon and nitrogen precursors, eliminating the need for basic additives.

🔹 The method exhibits broad functional group tolerance, including excellent compatibility with base-sensitive substrates and late-stage functionalization.

🔹 Electrophilic nitrogen precursors can be readily prepared from diverse starting materials, including C-H bonds and olefins.

🔹 A two-step, one-pot N-phenothiazination/C-N XEC sequence enables the efficient functionalization of amine-containing bioactive molecules and the synthesis of designer secondary, tertiary, and unsymmetrical diamines.

🔹 Mechanistic studies support a Ni(II)-aryl-amido intermediate as the key species responsible for promoting cross-selectivity while suppressing homocoupling.

🐝 We are pleased to see that 4,4'-di-tert-butyl-2,2'-bipyridine, a key ligand used in this study, was sourced from AmBeed.

𝗧𝗿𝘆 𝗔𝗺𝗕𝗲𝗲𝗱’𝘀 𝗯𝗶𝗽𝘆𝗿𝗶𝗱𝗶𝗻𝗲 𝗹𝗶𝗴𝗮𝗻𝗱𝘀 𝗶𝗻 𝘆𝗼𝘂𝗿 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵！

https://t.co/B546sShJLd

#AmBeed #JACS #OrganicChemistry #CrossElectrophileCoupling #NickelCatalysis #CNCoupling #Bipyridine #ResearchTools #BuildingBlocks #Paper #Chemistry

[Powers Lab @Powers_Lab]

Here is the link for the paper 🥂

https://t.co/N8RGYCbKyx

[Powers Lab @Powers_Lab]

We are excited to disclose our new work towards base-free nitrogen-centered radical XEC, now live at @J_A_C_S . Congratulations to @iamsamya96 , @LauvPatel , @mishti_2906, and Melissa for their hardwork and efforts!
https://t.co/qcuI02eV1U

[Powers Lab @Powers_Lab]

Excited to share that our article from 2024 is one of the Top Viewed Article in @angew_chem. Congratulations Dave! 🎉

Read it here https://t.co/JqmAa4u6Pk

#TopViewedArticle @wileyinresearch

[Organic Syntheses @OrgSynth]

Synthesis of N-Pyridinium Aziridines
Submitting Authors: Samya Samanta, Hao Tan, Saikat Chatterjee, David C. Powers
Checking Authors: Michael M. Gilbert and Nathan D. Ide
https://t.co/MmTX90xToO

[Powers Lab @Powers_Lab]

Congratulations to @arpanpaikar95, @figgins_matthew, @Gerard_VT and all involved in this work!

[Powers Lab @Powers_Lab]

Our latest @ChemicalScience paper reports the first crystal structure of hydrazoic acid bound to a transition metal. Cryogenic photolysis reveals the elusive triplet dirhodium imidogen intermediate enabling stereospecific NH aziridination of olefins. https://t.co/cmpwOfWwP2

[Powers Lab @Powers_Lab]

Our latest work in @J_A_C_S captures a reactive silver nitrene in crystallo an important but elusive intermediate in C–H functionalization. The triplet nitrene species is confirmed by further spectroscopy, and computation. Link:
https://t.co/B3Sf7oKDUN
Congrats to all involved!

[Powers Lab @Powers_Lab]

Congratulations to Dr. Phong Thai, Ph.D. #14 from the group! Phong's insight and curiosity to learn about reaction mechanisms and developing models to study them has been a massive benefit to the lab in general and we wish him all the success in his future endeavors.

[Powers Lab @Powers_Lab]

In our latest paper now out in @J_A_C_S, we report a combined experimental and computational investigation of N–H activation and C–N coupling promoted by anodically generated iodanyl radicals.
https://t.co/5UkS1x5jYp

[Powers Lab @Powers_Lab]

Congratulations to Arpan, Ph.D. #13 from our lab. Arpan has been a beacon of tenacity, and we are very proud of all his accomplishments. Wishing him the best in all his future endeavours!

[Powers Lab @Powers_Lab]

Excited to share our recent pre-print about PCO-group transfer by pincer-supported Ni-PCO complexe to provide P-Analogues of B-Lactams. Check it out here: https://t.co/e2wE2r81e5

[Powers Lab @Powers_Lab]

Congratulations to Aishanee, Ph.D. #12 from our lab. Aishanee will be joining Holland lab at Yale as a postdoc, we can't wait to see all the amazing chemistry she does there!

[Powers Lab @Powers_Lab]

Celebrating our 100th publication around our group's 10-year anniversary with our latest review on 'Synthesis and Application of Bioactive N‐Functionalized Aziridines' in @angew_chem. Check it out!
https://t.co/KAax6CKKsL

[Powers Lab @Powers_Lab]

Our latest work in @ChemicalScience investigates porous salt thin film growth mechanisms, and effects of thickness on metalation of the films. Congratulations to everyone involved in this paper from our lab, as well as our wonderful collaborators!
https://t.co/iiemQM0YBJ

[Powers Lab @Powers_Lab]

Check out our recent foray on Molecular Design Considerations for Azobenzene Anolytes in ACS Omega. Congratulations to Ananya, Uddalak, Haley and others involved. Excellent contributions from Dr. Gurkan and Dr. Pentzer.
@ACS_Omega
https://t.co/IYB3SAGei2

[Powers Lab @Powers_Lab]

In our latest paper now live at @ACSCatalysis, we probe the role of a new Co-based MOF in aerobic oxidation catalysis, and highlight the importance of carrying out kinetic experiments to evaluate the origins of catalytic activity.
https://t.co/BeL4jSJINl