The ProMOTE Study

Stage 2. RCT of conventional RARP vs molecularly-targeted intraoperative fluorescence. Trials unit @SITU_Oxford. Funder @CR_UK. CI @lambalastair. @NDSurgicalSci

[The ProMOTE Study @PromoteStudy]

Excited to publish our #FirstInMan phase 1 study using IR800-IAB2M (near infrared #PSMA minibody) dosing and toxicity in n=23 men undergoing #RARP +/- #ePLND

#ProstateCancer #PrecisionSurgery

@NDSurgicalSci @LambAlastair
@LabBryant

https://t.co/MNoFFT5S3o

[Alastair Lamb @LambAlastair]

If you're not here come now!!

eUro2, 1715-1800

@gu_onc "From Studio to Stage!!"

With @declangmurphy
& @RenuEapen

#EAU26 @Uroweb

[TRANSLATE Trial @TranslateTrial]

Pleased to publish #CostEffectiveness data #LATPvsTRUS in @EurUrolFocus

THM:
•average cost TRUS=£917; LATP=£1062 (∵ device cost/takes longer)
•#LATP not cost-effective (QALY)

But...
•only 4m f/u so doesnt account for ⬆️ PCa diag

#TRANSLATE_Trial

https://t.co/9Pq3TKwIsP

[Alastair Lamb @LambAlastair]

Fascinating on UK #PCaScreening
•Men 50-69 yo ❌️ (n=8.2M)
•Familial risk ❌️ (1M)
•Black ethnicity ❌️ (0.37M)
•BRCA mutated ✅️ (21k)

So...the screening gates opened for 1st time! 💥

Thoughtful from #NSC (but suspect many will be disappointed)

https://t.co/GWXOq6wGnj

[Alastair Lamb @LambAlastair]

Final case of the day (and of #ERUS25 @GuysUrology) with @bernardorocco73

#RARP modified anterior approach with @Medtronic #HUGO.

65 yo gent looking forward to retirement in Caribbean!
•GG3 8mm Rt ant, GG2 4mm Lt post
•T2N0M0
•ElIPSE trial - rndmed to no LND @BAUSurology

[Alastair Lamb @LambAlastair]

Final morning of #ERUS25, the sun is shining in anticipation of the first case of the day with @agalfano at @GuysUrology

Plan is for a @Medtronic #HUGO #rsRARP

Delightful portuguese gent with:
•GG2 6mm Rt anterior
•Borderline cT3a
•MUL 15mm
And fully aware of #LiveSurgery

[Alastair Lamb @LambAlastair]

First live case of #ERUS25 ready to rock @GuysUrology. @prokarurol in the #HUGO hot-seat. WHO time-out done. Patient from @GibraltarGov #StBernardsHospital & fully on board with #LiveSurgery concept

#CuttingEdgeSurgery
#EveryDaysALearningDay

[TRANSLATE Trial @TranslateTrial]

Co-Chief Investigator @LabBryant outlines #TRANSLATE_TRIAL journey during @NDSurgicalSci #SurgicalGrandRounds this morning.

@OCTRUctu @SITU_Oxford #SGR
#Oxford_Urology

[TRANSLATE Trial @TranslateTrial]

V grateful to @declangmurphy for his excellent, provocative & thoughtful "discussant" response to #TRANSLATE_Trial read-out by @LabBryant

@LambAlastair @NDSurgicalSci
@sashi_kommu @DrBenEddy
@HideYamaUrol @Mattpingchao

Watch it again in full here ⬇️

https://t.co/PZVmtxx6xQ

[TRANSLATE Trial @TranslateTrial]

Trial CI @LabBryant delighted to read out #TRANSLATE_Trial results during #GameChanger session @Uroweb #EAU25

Thank you to all our investigators, recruiting sites, funders @NIHRresearch and, most importantly, our 1126 pts!

https://t.co/HgQkrBKbsb

Trial visual abstract below ⬇️

[GU Cast | Urology podcast! @gu_onc]

Breaking news pod - TRANSLATE trial just presented at #EAU25 with co-publication @TheLancetOncol @LabBryant @LambAlastair @TranslateTrial. Discussant @declangmurphy Deep dive on GU Cast just released https://t.co/Ii6kUdvgei

[TRANSLATE Trial @TranslateTrial]

Excited to announce #TRANSLATE_Trial outcomes will read out at 10am Sun 23rd March in eURO Auditorium 1 #EAU25, Madrid

Synchronous embargoed publication in @TheLancetOncol

#LATPvsTRUS - we'll finally give you the answer

Hope to see you there!

@GUCast @LabBryant @LambAlastair

[Bryant_Lab @LabBryant]

@TranslateTrial results @Uroweb EAU Madrid, 10am Sunday 23/3/25, Green Area eURO Auditorium 1. #LATP v #TRUS prostate biopsy, n=1126; 1ry outcome GGG>=2 cancer detection, 2ry = infection, other complications, cost-effectiveness; @LambAlastair @LabBryant @NDSurgicalSci @OCTRUctu

[Anthony Bates @UroBates]

Last list on fellowship with @LambAlastair at @OUHospitals NHS Trust . HUGE thank you to Prof. Alastair Lamb, privilege to learn from you. TY for the invaluable masterclass in robot assisted radical prostatectomy. GRATITUDE to excellent scrub team members too! #SurgicalMentor

[Alastair Lamb @LambAlastair]

Today we publish first installment of #PROMOTE_Trial in @EANM_NucMed
#EJNMMI journal

n=23; 48% pT3b; 43% pN1
Node +ve fluoro n=8
Margin +ve fluoro n=10

Optimal dose of IR800-IAB2M PSMA minibody: 5mg iv 10d pre-RARP

@PromoteStudy funded by @CRUKresearch

https://t.co/JOVejY69QU

[Alastair Lamb @LambAlastair]

How to convert #RARP & #ProstateBx specimens into #CuttingEdge translational science?

State-of-the-Art Tips&Tricks video on #SpatialTranscriptomics analysis w #VisiumV2

@OxPCaBiol @NDSurgicalSci

Presented by @thineskrishna @ #AUA24

#OrganscaleNodes

https://t.co/pqqZ7PbViT

[Alastair Lamb @LambAlastair]

@Freddie_Hamdy drops the 🎤 @Prostate_Forum on thought expmt #FocalTherapy as "4th arm" in #ProtecT_Trial

Opponent: "well never be able to do RCT of Focal vs RP"

FCH: "Here's @PART_Trial, our RCT of partial vs radical Tx, international support & recruiting nicely" !!

#AUA24

[Oxford Prostate Cancer Biology Group @OxPCaBiol]

Please come see our poster showing how we use #SpatialTranscriptomics to deduce clonal metastatic relationships in high-risk surgically treated #prostatecancer

#LethalClone #Space_Study
@QuantumBiobank

@Wien_Yin & @Sandy_Figiel will answer all your qus!

@OxfordCancer #OxSymp24

[Alastair Lamb @LambAlastair]

Inviting appls to #Oxford_Urology pelvic uro-onc fellowship for Aug '24.
Approx cases pa 180 RARPs/40 RARCs/600 Bx (TRUS&LATP)

@IntuitiveSurg UK HQ in Oxford

Key role in 4 RCTs:
-@PromoteStudy
-@PART_Trial
-@AtlantaIp2
-FINESSE

Close: 15/12
Intv: 22/12

https://t.co/TRtGJfKogD

[Alastair Lamb @LambAlastair]

A great day of golf ⛳️ @ClubHuntercombe #CaptainsDay in support of @UCAREoxford w particular emphasis on fundraising for @NDSurgicalSci research nurse. Much needed to keep running novel trials/lab research to help our patients
And my awesome sister won Ladies Longest Drive!!🏆🍾