QUANTUM Biobank

QUAlity biobanking iNvestigaTing Urological Malignancies | @NDSurgicalSci | @UniOfOxford & Partners | PI @LambAlastair | Targetted, well-annotated collections

[QUANTUM Biobank @QuantumBiobank]

Delighted to announce that @QuantumBiobank is now open for business!

First 10 patients recruited from @TranslateTrial

Comprehensive fluid/tissue collections w trial-linked data
Inviting approaches for other costed sample collections

Straightforward TsofB

#TranslationalScience

[Alastair Lamb @LambAlastair]

If you're not here come now!!

eUro2, 1715-1800

@gu_onc "From Studio to Stage!!"

With @declangmurphy
& @RenuEapen

#EAU26 @Uroweb

[TRANSLATE Trial @TranslateTrial]

Pleased to publish #CostEffectiveness data #LATPvsTRUS in @EurUrolFocus

THM:
•average cost TRUS=£917; LATP=£1062 (∵ device cost/takes longer)
•#LATP not cost-effective (QALY)

But...
•only 4m f/u so doesnt account for ⬆️ PCa diag

#TRANSLATE_Trial

https://t.co/9Pq3TKwIsP

[Alastair Lamb @LambAlastair]

Final morning of #ERUS25, the sun is shining in anticipation of the first case of the day with @agalfano at @GuysUrology

Plan is for a @Medtronic #HUGO #rsRARP

Delightful portuguese gent with:
•GG2 6mm Rt anterior
•Borderline cT3a
•MUL 15mm
And fully aware of #LiveSurgery

[Alastair Lamb @LambAlastair]

First live case of #ERUS25 ready to rock @GuysUrology. @prokarurol in the #HUGO hot-seat. WHO time-out done. Patient from @GibraltarGov #StBernardsHospital & fully on board with #LiveSurgery concept

#CuttingEdgeSurgery
#EveryDaysALearningDay

[TRANSLATE Trial @TranslateTrial]

Co-Chief Investigator @LabBryant outlines #TRANSLATE_TRIAL journey during @NDSurgicalSci #SurgicalGrandRounds this morning.

@OCTRUctu @SITU_Oxford #SGR
#Oxford_Urology

[TRANSLATE Trial @TranslateTrial]

V grateful to @declangmurphy for his excellent, provocative & thoughtful "discussant" response to #TRANSLATE_Trial read-out by @LabBryant

@LambAlastair @NDSurgicalSci
@sashi_kommu @DrBenEddy
@HideYamaUrol @Mattpingchao

Watch it again in full here ⬇️

https://t.co/PZVmtxx6xQ

[TRANSLATE Trial @TranslateTrial]

Trial CI @LabBryant delighted to read out #TRANSLATE_Trial results during #GameChanger session @Uroweb #EAU25

Thank you to all our investigators, recruiting sites, funders @NIHRresearch and, most importantly, our 1126 pts!

https://t.co/HgQkrBKbsb

Trial visual abstract below ⬇️

[TRANSLATE Trial @TranslateTrial]

Excited to announce #TRANSLATE_Trial outcomes will read out at 10am Sun 23rd March in eURO Auditorium 1 #EAU25, Madrid

Synchronous embargoed publication in @TheLancetOncol

#LATPvsTRUS - we'll finally give you the answer

Hope to see you there!

@GUCast @LabBryant @LambAlastair

[Bryant_Lab @LabBryant]

@TranslateTrial results @Uroweb EAU Madrid, 10am Sunday 23/3/25, Green Area eURO Auditorium 1. #LATP v #TRUS prostate biopsy, n=1126; 1ry outcome GGG>=2 cancer detection, 2ry = infection, other complications, cost-effectiveness; @LambAlastair @LabBryant @NDSurgicalSci @OCTRUctu

[Alastair Lamb @LambAlastair]

Really like this little paper we've published in the brilliant new @BJUICompass on 10 yrs of #ASAP at #Oxford_Urology.

THM - not all subsequent biopsies after ASAP are #LowGrade. In fact 24.1% had GG≥2 within 2yrs of diagnosis of ASAP.

@thineskrishna

https://t.co/X4BP9YRFKM

[Alastair Lamb @LambAlastair]

Today we publish first installment of #PROMOTE_Trial in @EANM_NucMed
#EJNMMI journal

n=23; 48% pT3b; 43% pN1
Node +ve fluoro n=8
Margin +ve fluoro n=10

Optimal dose of IR800-IAB2M PSMA minibody: 5mg iv 10d pre-RARP

@PromoteStudy funded by @CRUKresearch

https://t.co/JOVejY69QU

[The ProMOTE Study @PromoteStudy]

Excited to publish our #FirstInMan phase 1 study using IR800-IAB2M (near infrared #PSMA minibody) dosing and toxicity in n=23 men undergoing #RARP +/- #ePLND

#ProstateCancer #PrecisionSurgery

@NDSurgicalSci @LambAlastair
@LabBryant

https://t.co/MNoFFT5S3o

[Nuffield Department of Surgical Sciences @NDSurgicalSci]

Congratulations to our newly appointed Associate Professors:

⭐️ Maria Kaisar
⭐️ Alastair Lamb
⭐️ Simon Knight
⭐️ Dan Woodcock

https://t.co/l3f8KZGqxz

[Alastair Lamb @LambAlastair]

How to convert #RARP & #ProstateBx specimens into #CuttingEdge translational science?

State-of-the-Art Tips&Tricks video on #SpatialTranscriptomics analysis w #VisiumV2

@OxPCaBiol @NDSurgicalSci

Presented by @thineskrishna @ #AUA24

#OrganscaleNodes

https://t.co/pqqZ7PbViT

[Oxford Prostate Cancer Biology Group @OxPCaBiol]

Are you interested in CTCs?
And the potential they offer to unpack clonal heterogeneity & mechanisms of metastasis in #ProstateCancer?

Come see @SophiaAbusamra's poster @OxfordCancer #OxSymp24

#LethalClone #Space_Study
@QuantumBiobank @NDSurgicalSci @ndorms

[Alastair Lamb @LambAlastair]

Inviting appls to #Oxford_Urology pelvic uro-onc fellowship for Aug '24.
Approx cases pa 180 RARPs/40 RARCs/600 Bx (TRUS&LATP)

@IntuitiveSurg UK HQ in Oxford

Key role in 4 RCTs:
-@PromoteStudy
-@PART_Trial
-@AtlantaIp2
-FINESSE

Close: 15/12
Intv: 22/12

https://t.co/TRtGJfKogD

[Oxford Prostate Cancer Biology Group @OxPCaBiol]

Honour for the group to present @NDSurgicalSci #SurgicalGrandRound this morning!

We covered synthetic biopsies, spatial clonal analyses, metabolic pathways, molecular imaging/therapy, commercial gene sigs, immune environment and more.

We love ❤️ researching #ProstateCancer!!

[Alastair Lamb @LambAlastair]

A great day of golf ⛳️ @ClubHuntercombe #CaptainsDay in support of @UCAREoxford w particular emphasis on fundraising for @NDSurgicalSci research nurse. Much needed to keep running novel trials/lab research to help our patients
And my awesome sister won Ladies Longest Drive!!🏆🍾

[Alastair Lamb @LambAlastair]

Really pleased to get our first look at @BioRad #GenesisCelSelect for next phase of #SPACE_Study.
#CTC
#SpatialGenomics
#LethalClone #OrganscaleNodes
@OxPCaBiol

https://t.co/kvHNVSDWkL

[Alastair Lamb @LambAlastair]

Great to see @bayraktar_lab's work using #SpatialTranscriptomics in brain cancer. And he works on #HES6 as well (my PhD!) - I really want to collaborate with this guy!!

@sangerinstitute @IdrmOxford
@NDSurgicalSci
@STomics @10xGenomics
#visium #xenium