Puneet Sharma

Founder@ | Revenue accelerant for B2B Tech startups | I also have the best WhatsApp GM messages.

[Puneet Sharma @PuneetSharmaX]

@DarioAmodei - "... cure most diseases in 5-10 years.." !!!

[Dario Amodei @DarioAmodei]

Today we announced the Claude-led discovery of a molecular machine that we suspect could represent a new gene editing mechanism. Its precise function, biotechnological utility (if any), or level of significance is not yet clear, but at minimum it is work I would have been proud to do as a PhD student. The work was done mostly, though not entirely, by Claude: our life sciences team suggested a broad area of research, Claude read through the literature and a bunch of genome data and discovered something interesting, then Claude proposed experiments to verify the discovery and our team carried them out.

It’s easy to dismiss this as a one-off or curiosity, but we’ve repeatedly seen a pattern where AI performance in new intellectual domains goes from weak to superhuman in a matter of a few years. In 2023 models struggled to do math at the level of an average high-school student. In 2024 they started to do well on math competitions for the best high-schoolers in the country, in 2025 they started to solve minor open problems, in early 2026 more significant open problems, and in late 2026 they are beginning to solve the top few open problems in all of mathematics. We believe AI for biology is on a similar exponential trend.

The main difference between biology and mathematics, of course, is that math can be done purely theoretically, while biology requires experimentation. Some have used this to draw the conclusion that AI’s utility in biology will be limited. We think this is wrong. As we’ve demonstrated today, humans can collaborate with AI to perform the experiments, validate key results in a few weeks and, if necessary, work with the AI to iterate on what they find. Eventually it may even be possible for Claude itself to safely perform the experiments by autonomously controlling lab equipment, with appropriate safeguards in place, but we aren’t doing that today (our lab is also a BSL1/BSL2 facility that doesn't handle materials dangerous to humans).

More broadly, biomedical advancement has many stages — from fundamental biology discoveries, to translational research, to drug discovery, clinical trials, and finally the actual delivery of medicines and health care to patients. We are also interested in these later stages, but even simply accelerating the first stage of fundamental biological discoveries has the potential to speed up and broaden the entire pipeline. Improving our understanding of biology and sharpening biologists’ tools can drive forward all of the later stages, for example by identifying new drug targets, finding new therapeutic modalities, allowing for more precise measurement, and speeding up the experimental loop which itself further accelerates our understanding of biology. This will not in itself speed up clinical trial times, but if it succeeds it could greatly increase the number of promising candidates that go into the pipeline — an increase in throughput even though latency remains.

In Machines of Loving Grace, I wrote about AI’s potential to “cure most diseases in 5-10 years” — a goal that sounds impossible, but one I believe is just barely possible if AI is applied to every stage of the pipeline. The first step is showing that AI can first help with, and then drive, biological discoveries.

Claude’s discovery is the latest in a line of related prior work that goes back decades, beginning with systems like CRISPR, and continuing with discoveries like the bridge recombinase and VIPR in the past few years. Recently, there has been heightened interest in systems based on reverse transcriptase (RT) enzymes, the enzyme underlying the system Claude identified. And most recently, a Stanford team working independently described a novel RT system with an associated non-coding array that is in some ways similar to the one Claude found, though they are distinct systems that evolved independently from each other. I believe that we’re at the very beginning of finding such systems and developing them into powerful tools for biotechnology.

I’m proud of the resources Anthropic has invested in accelerating the public benefits of AI through the life sciences, and we’re aiming both to grow our life sciences team and to work with other scientists to extend this approach to a broad range of problems. If you have a proposal for a research collaboration or are interested in joining our life sciences team, please reach out.

[Skyroot Aerospace @SkyrootA]

ORBIT ACHIEVED. 🚀

Vikram-1 Test Flight-1 has reached orbit. India's first privately developed orbital rocket has completed its final burn and injected its payloads into a ~450 km orbit, making India the third country in the world with private orbital launch capability.

History is made. 🇮🇳

#Vikram1 #JourneyToOrbit #SkyrootAerospace

[Puneet Sharma @PuneetSharmaX]

@tunkuv btw til - your own original name - hugely more famous name.

[Puneet Sharma @PuneetSharmaX]

Happy 2026 !

[MaxedS @MaxedSHQ]

Looking for B2B tech startups keen to enter/expand in US

https://t.co/V3l6UziLcm

[Scott Adams @ScottAdamsSays]

A Final Message From Scott Adams

[Puneet Sharma @PuneetSharmaX]

@pankajag1973 @SatyapalMalik6 ….मेहनत कर “रहे” है ?

[Puneet Sharma @PuneetSharmaX]

@vishalmisra @niteshtiwari22 ah the joy of random Twitter.

Was h3 really seen as such an awesome hostel by h4 bkites :)

[Puneet Sharma @PuneetSharmaX]

@Austen @ShedCapitalLLC @sabrmattrics Sorry, I meant the order has some language about letting students cancel loans etc.

Does this all carry a financial impact to your firm or it’s just fluffy language to declare victory ?

[Puneet Sharma @PuneetSharmaX]

@engineers_feed @noahkagan just put the word, then delete all emails.
did it.
gmail is still processing the deletion.

[Puneet Sharma @PuneetSharmaX]

@sahir2k @TechEmails No . 11 Michael Lewis. How is he sure of landing both.

[Puneet Sharma @PuneetSharmaX]

@BSF_Rajasthan @BSF_India @HMOIndia @BSF_SDG_WC @PIBJaipur @DDNewsRajasthan @zeerajasthan_ @News18Rajasthan @FirstIndiaNews3 @DainikBhaskar @DailyNavajyoti Just heard about Makrand in our H3 group. All the best 👍👍

[Puneet Sharma @PuneetSharmaX]

@SubramanianKri Congrats Subbu. Very nice pics 👍👍

[Puneet Sharma @PuneetSharmaX]

https://t.co/ot1bQTMHYu

We are pleased to announce a new win at a Fortune 500 for @GlobalPayEX. AI in Finance !

Vertical AI in Legal, SCM & Martech is hot rn.

If you are an AI startup in any of these then please ping. Uncle Sam wants you :)

[Puneet Sharma @PuneetSharmaX]

@dsrose @BobKnakal @sweatystartup If you made 750K after 10 years @ 75K isn’t that like a typical job ?

[Puneet Sharma @PuneetSharmaX]

@Syzler2 @keyladelslay @memeticsisyphus @MarkEwellCO Very well said. A rabid dog is an apt comparison.

Q - if you now have a cure for rabies then would you still put it down or try curing it. Maybe Dog is afflicted and potentially unhappy with its state ?

Earlier we had only one option. Maybe Science has progressed ?

[Puneet Sharma @PuneetSharmaX]

@keyladelslay @memeticsisyphus @MarkEwellCO Some quacks may mean ducks too.

Is it remotely possible that somebody who killed so heinously may have a mental condition.

Would you want society to take somebody off without being 💯. That’s life too.

[Puneet Sharma @PuneetSharmaX]

@ShlokSharmaybe @movieboy69 😂😂😂 yep

[The Echo @NVHS_Echo]

Congrats Maya!!