Qi Chen

PI in GIBH, CAS. working on hematopoietic stem cell and vascular biology. Opinions are my own,not related with employer.

[Qi Chen @Qi39910]

Happy to share a new work from my lab published in Cell https://t.co/1k49EcolAk We establish a time-series endothelial atlas covering entire mice embryonic development, which help us to identify Casz1 as critical gene for lung vascular development.

[Chinese Academy of Sciences @CAS__Science]

🧬 We drew a "growth map" of the vascular system, revealing how blood vessels form organ-specific identities during embryonic development.
This map solves a long-standing mystery and provides a blueprint for repairing or regenerating the body's vital vessel networks.

#CAS #BiomedicalResearch #HumanHealth #Genetics #DevelopmentalBiology #VascularBiology

[Qi Chen @Qi39910]

@kishorsivaraj Thanks a lot. Hope to meet you again in vascular biology meeting this year

[Qi Chen @Qi39910]

@BiomedErs Thank you for your interest，but it is difficult to explain in more details in Twitter. We have uploaded all code in Github，which include everything.

[Qi Chen @Qi39910]

Happy to share a new work from my lab published in Cell https://t.co/1k49EcolAk We establish a time-series endothelial atlas covering entire mice embryonic development, which help us to identify Casz1 as critical gene for lung vascular development.

[Cell @CellCellPress]

Now online! A single-cell time-series atlas of endothelial cell embryonic development https://t.co/7DheWge2Jj

[Vishal Mohanakrishnan @vishalmkrishnan]

Bone remodeling is traditionally driven by osteoblasts and osteoclasts, but our study reveals a third essential player: "Type R capillaries".

Excited to share my PhD work from @ralfhadams lab, now published in @NatureCellBio.

https://t.co/KMTIlSBnjl
🧵1/8👇 🐭🔬🦴

[Qi Chen @Qi39910]

@CarebyEmily Regarding impact to neurovascular coupling, I would suggest to perform more cell-cell communication prediction based on scRNA-seq, which is not very popular in that field as far as I know. But based on my experience, this approach may uncover new coupling mechanism.

[Qi Chen @Qi39910]

Neurovascular coupling has been investigated for decades but no other cells are reported to have similar nice alignment with blood vessel. Our recent work reports the importance of ductal-endothelial alignment during pancreatic inflammation.

https://t.co/ONg7g97dpM

[Qi Chen @Qi39910]

@CarebyEmily Many thanks for your interest. For some reason, we have not gone that deep to fully uncover the molecular mechanism governing epithelial-endothelial coupling. But in Fig.S1, it is very apparent that blood vessel provides template and attract ductal epithelial cell

[Qi Chen @Qi39910]

@kishorsivaraj Thanks and wish to see work from your team

[Qi Chen @Qi39910]

@ralfhadams Many thanks.

[Qi Chen @Qi39910]

@HaoYin20 Many thanks, caerulein is a well-established model, but vascular contribution to this field seems to be new in literature.

[Shiri Gur-Cohen 🟦 @ShiriGurCohen]

The moment when stem cells switch their niches during development is absolutely fascinating, and ⁦@ralfhadams⁩ lab just showed us how is that happening. Fabulous work🤩🔥!!! A specialized bone marrow microenvironment for fetal haematopoiesis | https://t.co/JlmFCAKIB0

[Qi Chen @Qi39910]

@vishalmkrishnan Thank you

[Qi Chen @Qi39910]

Our work done by Yang,me,@HyunWooJeong1 @bikohcello @DrEmmaCWatson et al in @ralfhadams lab is out in @NatureComms https://t.co/gb21Zs8EE7 We find artery guides initial entry of HSC into fetal bone marrow. @endothelialnews @HSC_papers @Hema_News

[Qi Chen @Qi39910]

@kishorsivaraj Thanks Kishor, also congratulate for yours. Looking forward for next one

[Qi Chen @Qi39910]

@Dhapubavi Thanks Bavi

[Qi Chen @Qi39910]

@gou_koh Thanks for your interest to our paper. And many helps from Bong-Ihn to finalize the remaining experiment

[Qi Chen @Qi39910]

@TomItkin Many thanks. That's exactly our point :)

[Qi Chen @Qi39910]

@kishorsivaraj sincere congratulations